'en:muscle weakness begins proximally'
(id=9094518 ; fe=en:muscle weakness begins proximally ; type=1 ; niveau=200 ; luminosité=25 ; somme entrante=25714 creation date=2017-10-27 touchdate=2025-07-25 19:10:46.000)

≈ 823 relations sortantes en:muscle weakness begins proximally -- r_associated #0: 25 / 1 -> en:muscle n1=en:muscle weakness begins proximally | n2=en:muscle | rel=r_associated | relid=0 | w=25 en:muscle weakness begins proximally -- r_associated #0: 25 / 1 -> en:muscle weakness n1=en:muscle weakness begins proximally | n2=en:muscle weakness | rel=r_associated | relid=0 | w=25 en:muscle weakness begins proximally -- r_associated #0: 25 / 1 -> faiblesse n1=en:muscle weakness begins proximally | n2=faiblesse | rel=r_associated | relid=0 | w=25 en:muscle weakness begins proximally -- r_associated #0: 21 / 0.84 -> en:abdominal wall muscle weakness (later onset) n1=en:muscle weakness begins proximally | n2=en:abdominal wall muscle weakness (later onset) | rel=r_associated | relid=0 | w=21 en:muscle weakness begins proximally -- r_associated #0: 21 / 0.84 -> en:abnormal aggregation of mitochondria n1=en:muscle weakness begins proximally | n2=en:abnormal aggregation of mitochondria | rel=r_associated | relid=0 | w=21 en:muscle weakness begins proximally -- r_associated #0: 21 / 0.84 -> en:abnormal changes in the organization of the sarcolemma and the subsarcolemmal membrane cytoskeleton n1=en:muscle weakness begins proximally | n2=en:abnormal changes in the organization of the sarcolemma and the subsarcolemmal membrane cytoskeleton | rel=r_associated | relid=0 | w=21 en:muscle weakness begins proximally -- r_associated #0: 21 / 0.84 -> en:abnormal fatigue n1=en:muscle weakness begins proximally | n2=en:abnormal fatigue | rel=r_associated | relid=0 | w=21 en:muscle weakness begins proximally -- r_associated #0: 21 / 0.84 -> en:abnormal mitochondria with loss of cristae n1=en:muscle weakness begins proximally | n2=en:abnormal mitochondria with loss of cristae | rel=r_associated | relid=0 | w=21 en:muscle weakness begins proximally -- r_associated #0: 21 / 0.84 -> en:abnormal muscle fibers with amorphous, granular, or hyaline deposits n1=en:muscle weakness begins proximally | n2=en:abnormal muscle fibers with amorphous, granular, or hyaline deposits | rel=r_associated | relid=0 | w=21 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:a subset of patients develop bilateral weakness n1=en:muscle weakness begins proximally | n2=en:a subset of patients develop bilateral weakness | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:a subset of patients have aggravation on cold exposure ('cold paresis') n1=en:muscle weakness begins proximally | n2=en:a subset of patients have aggravation on cold exposure ('cold paresis') | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:abdominal muscle hypoplasia n1=en:muscle weakness begins proximally | n2=en:abdominal muscle hypoplasia | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:abnormal distribution of subcutaneous fat n1=en:muscle weakness begins proximally | n2=en:abnormal distribution of subcutaneous fat | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:abnormal fat pad, buttocks and upper thighs (in some patients) n1=en:muscle weakness begins proximally | n2=en:abnormal fat pad, buttocks and upper thighs (in some patients) | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:abnormal fiber size variation n1=en:muscle weakness begins proximally | n2=en:abnormal fiber size variation | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:abnormal iron deposition in mitochondria n1=en:muscle weakness begins proximally | n2=en:abnormal iron deposition in mitochondria | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:abnormal irregular myofibrillar network n1=en:muscle weakness begins proximally | n2=en:abnormal irregular myofibrillar network | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:abnormal mitochondria n1=en:muscle weakness begins proximally | n2=en:abnormal mitochondria | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:abnormal mitochondria in skeletal muscle biopsy n1=en:muscle weakness begins proximally | n2=en:abnormal mitochondria in skeletal muscle biopsy | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:abnormal size and shape of synaptic endplates n1=en:muscle weakness begins proximally | n2=en:abnormal size and shape of synaptic endplates | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:abnormal variation in fiber type seen on muscle biopsy n1=en:muscle weakness begins proximally | n2=en:abnormal variation in fiber type seen on muscle biopsy | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:abnormalities in myofibril organization n1=en:muscle weakness begins proximally | n2=en:abnormalities in myofibril organization | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:absence of gamma-sarcoglycan protein n1=en:muscle weakness begins proximally | n2=en:absence of gamma-sarcoglycan protein | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:absence of immunostaining for alpha- and beta-dystroglycan (family b) n1=en:muscle weakness begins proximally | n2=en:absence of immunostaining for alpha- and beta-dystroglycan (family b) | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:absence of laminin alpha-2 chain in muscle n1=en:muscle weakness begins proximally | n2=en:absence of laminin alpha-2 chain in muscle | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:absence of merosin in muscle n1=en:muscle weakness begins proximally | n2=en:absence of merosin in muscle | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:absence of myotonia in infancy (congenital form) n1=en:muscle weakness begins proximally | n2=en:absence of myotonia in infancy (congenital form) | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:absence of necrosis n1=en:muscle weakness begins proximally | n2=en:absence of necrosis | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:absence of spontaneous activity at birth (severe form) n1=en:muscle weakness begins proximally | n2=en:absence of spontaneous activity at birth (severe form) | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:absence of telethonin protein n1=en:muscle weakness begins proximally | n2=en:absence of telethonin protein | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:accelerated decay of the synaptic current n1=en:muscle weakness begins proximally | n2=en:accelerated decay of the synaptic current | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:accumulation of intrasarcoplasmic granulofilamentous aggregates that are immunoreactive to desmin and alpha-beta-crystallin n1=en:muscle weakness begins proximally | n2=en:accumulation of intrasarcoplasmic granulofilamentous aggregates that are immunoreactive to desmin and alpha-beta-crystallin | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:acetazolamide may worsen symptoms n1=en:muscle weakness begins proximally | n2=en:acetazolamide may worsen symptoms | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:acquire ability to walk and jump in childhood, but motor regression occurs later n1=en:muscle weakness begins proximally | n2=en:acquire ability to walk and jump in childhood, but motor regression occurs later | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:affected muscles show atrophy n1=en:muscle weakness begins proximally | n2=en:affected muscles show atrophy | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:almost complete absence of large diameter fibers n1=en:muscle weakness begins proximally | n2=en:almost complete absence of large diameter fibers | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:amyloid deposition in muscle fibers occurs rarely n1=en:muscle weakness begins proximally | n2=en:amyloid deposition in muscle fibers occurs rarely | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:amyotrophy, distal, upper and lower limbs n1=en:muscle weakness begins proximally | n2=en:amyotrophy, distal, upper and lower limbs | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:angular fibers (in some patients) n1=en:muscle weakness begins proximally | n2=en:angular fibers (in some patients) | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:angulated atrophic fibers n1=en:muscle weakness begins proximally | n2=en:angulated atrophic fibers | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:angulated atrophic muscle fibers n1=en:muscle weakness begins proximally | n2=en:angulated atrophic muscle fibers | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:angulated fibers n1=en:muscle weakness begins proximally | n2=en:angulated fibers | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:anterior tibial muscles first involved n1=en:muscle weakness begins proximally | n2=en:anterior tibial muscles first involved | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:apoptotic nuclei n1=en:muscle weakness begins proximally | n2=en:apoptotic nuclei | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:areflexia due to muscle weakness n1=en:muscle weakness begins proximally | n2=en:areflexia due to muscle weakness | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:atrophic calf muscles n1=en:muscle weakness begins proximally | n2=en:atrophic calf muscles | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:atrophic fibers n1=en:muscle weakness begins proximally | n2=en:atrophic fibers | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:atrophic muscle fiber on biopsy n1=en:muscle weakness begins proximally | n2=en:atrophic muscle fiber on biopsy | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:atrophy of ankle and toe extensor (dorsiflexor) muscles n1=en:muscle weakness begins proximally | n2=en:atrophy of ankle and toe extensor (dorsiflexor) muscles | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:atrophy of anterior compartment tibial muscles n1=en:muscle weakness begins proximally | n2=en:atrophy of anterior compartment tibial muscles | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:atrophy of neck muscles may occur later n1=en:muscle weakness begins proximally | n2=en:atrophy of neck muscles may occur later | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:atrophy of the intrinsic foot and hand muscles n1=en:muscle weakness begins proximally | n2=en:atrophy of the intrinsic foot and hand muscles | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:atrophy of the lower leg muscles n1=en:muscle weakness begins proximally | n2=en:atrophy of the lower leg muscles | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:atrophy of the muscles in the anterior compartment of the lower leg n1=en:muscle weakness begins proximally | n2=en:atrophy of the muscles in the anterior compartment of the lower leg | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:atrophy of the thenar and hypothenar muscles n1=en:muscle weakness begins proximally | n2=en:atrophy of the thenar and hypothenar muscles | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:attacks last 4 to 24 hours n1=en:muscle weakness begins proximally | n2=en:attacks last 4 to 24 hours | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:attacks precipitated by cold temperature n1=en:muscle weakness begins proximally | n2=en:attacks precipitated by cold temperature | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:attacks precipitated by hypokalemia, administration of glucose or insulin, heavy carbohydrate consumption, stress, fatigue, rest after exercise n1=en:muscle weakness begins proximally | n2=en:attacks precipitated by hypokalemia, administration of glucose or insulin, heavy carbohydrate consumption, stress, fatigue, rest after exercise | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:attacks precipitated by potassium n1=en:muscle weakness begins proximally | n2=en:attacks precipitated by potassium | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:attacks precipitated by rest after exercise n1=en:muscle weakness begins proximally | n2=en:attacks precipitated by rest after exercise | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:attacks relieved by potassium administration n1=en:muscle weakness begins proximally | n2=en:attacks relieved by potassium administration | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:attacks usually decrease or disappear after age 40 years n1=en:muscle weakness begins proximally | n2=en:attacks usually decrease or disappear after age 40 years | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:autophagic rimmed vacuoles n1=en:muscle weakness begins proximally | n2=en:autophagic rimmed vacuoles | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:autophagic vacuoles with multilamellar structures seen on electron microscopy n1=en:muscle weakness begins proximally | n2=en:autophagic vacuoles with multilamellar structures seen on electron microscopy | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:biceps brachii atrophy n1=en:muscle weakness begins proximally | n2=en:biceps brachii atrophy | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:bilateral facial weakness (congenital form) n1=en:muscle weakness begins proximally | n2=en:bilateral facial weakness (congenital form) | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:biopsy of adipose tissue shows reduced adipocyte size n1=en:muscle weakness begins proximally | n2=en:biopsy of adipose tissue shows reduced adipocyte size | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:biopsy shows defects in pyruvate oxidation n1=en:muscle weakness begins proximally | n2=en:biopsy shows defects in pyruvate oxidation | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:biopsy shows dystrophic changes n1=en:muscle weakness begins proximally | n2=en:biopsy shows dystrophic changes | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:biopsy shows nonspecific myopathy without rimmed vacuoles n1=en:muscle weakness begins proximally | n2=en:biopsy shows nonspecific myopathy without rimmed vacuoles | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:biopsy shows rimmed vacuoles, central nuclei, and variation in fiber size n1=en:muscle weakness begins proximally | n2=en:biopsy shows rimmed vacuoles, central nuclei, and variation in fiber size | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:both type 1 and type 2 fiber predominance has been reported n1=en:muscle weakness begins proximally | n2=en:both type 1 and type 2 fiber predominance has been reported | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:by fourth decade, many patients need help with ambulation n1=en:muscle weakness begins proximally | n2=en:by fourth decade, many patients need help with ambulation | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:calf atrophy (later onset) n1=en:muscle weakness begins proximally | n2=en:calf atrophy (later onset) | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:calf hypertrophy (early in the disease) n1=en:muscle weakness begins proximally | n2=en:calf hypertrophy (early in the disease) | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:calf hypertrophy (less common) n1=en:muscle weakness begins proximally | n2=en:calf hypertrophy (less common) | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:calf hypertrophy (reported in 1 family) n1=en:muscle weakness begins proximally | n2=en:calf hypertrophy (reported in 1 family) | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:calf hypertrophy (uncommon) n1=en:muscle weakness begins proximally | n2=en:calf hypertrophy (uncommon) | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:calf muscle discomfort n1=en:muscle weakness begins proximally | n2=en:calf muscle discomfort | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:calf muscle hypertrophy n1=en:muscle weakness begins proximally | n2=en:calf muscle hypertrophy | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:calf muscle pseudohypertrophy n1=en:muscle weakness begins proximally | n2=en:calf muscle pseudohypertrophy | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:calf pseudohypertrophy rare n1=en:muscle weakness begins proximally | n2=en:calf pseudohypertrophy rare | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:cellulitis or infection may occur n1=en:muscle weakness begins proximally | n2=en:cellulitis or infection may occur | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:centralized myonuclei n1=en:muscle weakness begins proximally | n2=en:centralized myonuclei | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:centralized nuclei may be seen n1=en:muscle weakness begins proximally | n2=en:centralized nuclei may be seen | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:centralized nuclei, rare n1=en:muscle weakness begins proximally | n2=en:centralized nuclei, rare | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:changes in sarcoplasmic reticulum and t-tubules n1=en:muscle weakness begins proximally | n2=en:changes in sarcoplasmic reticulum and t-tubules | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:chronic neurogenic changes seen on emg n1=en:muscle weakness begins proximally | n2=en:chronic neurogenic changes seen on emg | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:congenital absence of gluteal muscles n1=en:muscle weakness begins proximally | n2=en:congenital absence of gluteal muscles | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:congenital myasthenic syndrome (reported in 1 patient who survived to age 20 years) n1=en:muscle weakness begins proximally | n2=en:congenital myasthenic syndrome (reported in 1 patient who survived to age 20 years) | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:congenital, nonprogressive myopathy n1=en:muscle weakness begins proximally | n2=en:congenital, nonprogressive myopathy | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:congophilic amyloid material n1=en:muscle weakness begins proximally | n2=en:congophilic amyloid material | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:congophilic deposits n1=en:muscle weakness begins proximally | n2=en:congophilic deposits | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:congophilic inclusions n1=en:muscle weakness begins proximally | n2=en:congophilic inclusions | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:congophilic staining n1=en:muscle weakness begins proximally | n2=en:congophilic staining | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:cores contain densely packed myofilaments n1=en:muscle weakness begins proximally | n2=en:cores contain densely packed myofilaments | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:cores extend along length of muscle fiber n1=en:muscle weakness begins proximally | n2=en:cores extend along length of muscle fiber | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:cores have abrupt borders within normal regions of the muscle fiber n1=en:muscle weakness begins proximally | n2=en:cores have abrupt borders within normal regions of the muscle fiber | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:cores or minicores n1=en:muscle weakness begins proximally | n2=en:cores or minicores | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:cores with lack of oxidative activity and mitochondrial depletion may also be found and extend along length of fiber n1=en:muscle weakness begins proximally | n2=en:cores with lack of oxidative activity and mitochondrial depletion may also be found and extend along length of fiber | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:cranial muscles spared n1=en:muscle weakness begins proximally | n2=en:cranial muscles spared | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:cytochrome c oxidase-negative fibers n1=en:muscle weakness begins proximally | n2=en:cytochrome c oxidase-negative fibers | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:cytoplasmic inclusion bodies (finding) n1=en:muscle weakness begins proximally | n2=en:cytoplasmic inclusion bodies (finding) | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:decreased ability to run n1=en:muscle weakness begins proximally | n2=en:decreased ability to run | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:decreased achr n1=en:muscle weakness begins proximally | n2=en:decreased achr | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:decreased activities of mitochondrial-encoded respiratory chain complexes n1=en:muscle weakness begins proximally | n2=en:decreased activities of mitochondrial-encoded respiratory chain complexes | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:decreased activity of cytochrome c oxidase in most cases seen on muscle biopsy n1=en:muscle weakness begins proximally | n2=en:decreased activity of cytochrome c oxidase in most cases seen on muscle biopsy | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:decreased activity of cytochrome c oxidase seen on muscle biopsy n1=en:muscle weakness begins proximally | n2=en:decreased activity of cytochrome c oxidase seen on muscle biopsy | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:decreased activity of multiple mitochondrial respiratory complex enzymes n1=en:muscle weakness begins proximally | n2=en:decreased activity of multiple mitochondrial respiratory complex enzymes | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:decreased adipose tissue around neck n1=en:muscle weakness begins proximally | n2=en:decreased adipose tissue around neck | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:decreased atp production n1=en:muscle weakness begins proximally | n2=en:decreased atp production | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:decreased caveolae in muscle tissue n1=en:muscle weakness begins proximally | n2=en:decreased caveolae in muscle tissue | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:decreased caveolin-3 expression on muscle biopsy n1=en:muscle weakness begins proximally | n2=en:decreased caveolin-3 expression on muscle biopsy | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:decreased caveolin-3 expression seen on muscle biopsy n1=en:muscle weakness begins proximally | n2=en:decreased caveolin-3 expression seen on muscle biopsy | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:decreased cytochrome c oxidase activity n1=en:muscle weakness begins proximally | n2=en:decreased cytochrome c oxidase activity | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:decreased cytochrome c oxidase staining n1=en:muscle weakness begins proximally | n2=en:decreased cytochrome c oxidase staining | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:decreased distal reflexes n1=en:muscle weakness begins proximally | n2=en:decreased distal reflexes | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:decreased endplate potential and amplitudes n1=en:muscle weakness begins proximally | n2=en:decreased endplate potential and amplitudes | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:decreased exercise tolerance n1=en:muscle weakness begins proximally | n2=en:decreased exercise tolerance | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:decreased glutamate oxidation (about 63% of normal) n1=en:muscle weakness begins proximally | n2=en:decreased glutamate oxidation (about 63% of normal) | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:decreased glycosylation of alpha-dystroglycan n1=en:muscle weakness begins proximally | n2=en:decreased glycosylation of alpha-dystroglycan | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:decreased hand grip strength n1=en:muscle weakness begins proximally | n2=en:decreased hand grip strength | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:decreased immunostaining for alpha-sarcoglycan n1=en:muscle weakness begins proximally | n2=en:decreased immunostaining for alpha-sarcoglycan | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:decreased lactate clearance from muscle after exercise (reported in 1 patient) n1=en:muscle weakness begins proximally | n2=en:decreased lactate clearance from muscle after exercise (reported in 1 patient) | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:decreased lipoic acid n1=en:muscle weakness begins proximally | n2=en:decreased lipoic acid | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:decreased miniature endplate potential (mepp) and current (mepc) n1=en:muscle weakness begins proximally | n2=en:decreased miniature endplate potential (mepp) and current (mepc) | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:decreased mitochondria n1=en:muscle weakness begins proximally | n2=en:decreased mitochondria | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:decreased muscle action potential after warming affected muscle n1=en:muscle weakness begins proximally | n2=en:decreased muscle action potential after warming affected muscle | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:decreased muscle bulk n1=en:muscle weakness begins proximally | n2=en:decreased muscle bulk | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:decreased muscle bulk (in one patient) n1=en:muscle weakness begins proximally | n2=en:decreased muscle bulk (in one patient) | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:decreased muscle density on imaging n1=en:muscle weakness begins proximally | n2=en:decreased muscle density on imaging | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:decreased muscle mass n1=en:muscle weakness begins proximally | n2=en:decreased muscle mass | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:decreased muscle mass (especially in lower limbs) n1=en:muscle weakness begins proximally | n2=en:decreased muscle mass (especially in lower limbs) | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:decreased muscle mitochondrial aconitase n1=en:muscle weakness begins proximally | n2=en:decreased muscle mitochondrial aconitase | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:decreased muscle succinate dehydrogenase n1=en:muscle weakness begins proximally | n2=en:decreased muscle succinate dehydrogenase | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:decreased numbers of acetylcholine receptors (achr) in the postsynaptic membrane (less than 50% of normal) n1=en:muscle weakness begins proximally | n2=en:decreased numbers of acetylcholine receptors (achr) in the postsynaptic membrane (less than 50% of normal) | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:decreased numbers of achr seen on muscle biopsy n1=en:muscle weakness begins proximally | n2=en:decreased numbers of achr seen on muscle biopsy | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:decreased numbers of postsynaptic nerve terminals at the neuromuscular junction n1=en:muscle weakness begins proximally | n2=en:decreased numbers of postsynaptic nerve terminals at the neuromuscular junction | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:decreased or patchy amounts of alpha-dystrobrevin and beta-2-syntrophin at the sarcolemma n1=en:muscle weakness begins proximally | n2=en:decreased or patchy amounts of alpha-dystrobrevin and beta-2-syntrophin at the sarcolemma | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:decreased postsynaptic length n1=en:muscle weakness begins proximally | n2=en:decreased postsynaptic length | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:decreased quantal release n1=en:muscle weakness begins proximally | n2=en:decreased quantal release | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:decreased shank muscle mass n1=en:muscle weakness begins proximally | n2=en:decreased shank muscle mass | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:decreased spontaneous miniature endplate potentials (mepp) n1=en:muscle weakness begins proximally | n2=en:decreased spontaneous miniature endplate potentials (mepp) | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:decreased thiamine pyrophosphate n1=en:muscle weakness begins proximally | n2=en:decreased thiamine pyrophosphate | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:decremental cmap response to repetitive nerve stimulation n1=en:muscle weakness begins proximally | n2=en:decremental cmap response to repetitive nerve stimulation | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:decremental cmap response to repetitive nerve stimulation seen on emg n1=en:muscle weakness begins proximally | n2=en:decremental cmap response to repetitive nerve stimulation seen on emg | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:decremental compound muscle action potential (cmap) in response to repetitive nerve stimulation seen on emg n1=en:muscle weakness begins proximally | n2=en:decremental compound muscle action potential (cmap) in response to repetitive nerve stimulation seen on emg | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:decremental compound muscle action potential on repetitive stimulation n1=en:muscle weakness begins proximally | n2=en:decremental compound muscle action potential on repetitive stimulation | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:decremental response to repetitive stimulation at neuromuscular junction n1=en:muscle weakness begins proximally | n2=en:decremental response to repetitive stimulation at neuromuscular junction | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:deep finger muscle weakness n1=en:muscle weakness begins proximally | n2=en:deep finger muscle weakness | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:defective mitochondrial oxidative phosphorylation of multiple enzymes n1=en:muscle weakness begins proximally | n2=en:defective mitochondrial oxidative phosphorylation of multiple enzymes | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:degenerating fibers n1=en:muscle weakness begins proximally | n2=en:degenerating fibers | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:degenerating junctional folds n1=en:muscle weakness begins proximally | n2=en:degenerating junctional folds | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:degenerating nerve terminals n1=en:muscle weakness begins proximally | n2=en:degenerating nerve terminals | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:degeneration of junctional folds n1=en:muscle weakness begins proximally | n2=en:degeneration of junctional folds | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:degenerative changes with increased connective tissue n1=en:muscle weakness begins proximally | n2=en:degenerative changes with increased connective tissue | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:deltoid muscle hypoplasia n1=en:muscle weakness begins proximally | n2=en:deltoid muscle hypoplasia | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:dense membranous structure surrounding nuclei on electron microscopy n1=en:muscle weakness begins proximally | n2=en:dense membranous structure surrounding nuclei on electron microscopy | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:denuded postsynaptic regions n1=en:muscle weakness begins proximally | n2=en:denuded postsynaptic regions | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:dependent edema after excess fat has been present for several years n1=en:muscle weakness begins proximally | n2=en:dependent edema after excess fat has been present for several years | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:deposits immunoreactive to beta-amyloid protein n1=en:muscle weakness begins proximally | n2=en:deposits immunoreactive to beta-amyloid protein | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:difficulty climbing stairs, jumping, running n1=en:muscle weakness begins proximally | n2=en:difficulty climbing stairs, jumping, running | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:difficulty in toe walking n1=en:muscle weakness begins proximally | n2=en:difficulty in toe walking | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:difficulty rising from a squatting position n1=en:muscle weakness begins proximally | n2=en:difficulty rising from a squatting position | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:difficulty rising from chair n1=en:muscle weakness begins proximally | n2=en:difficulty rising from chair | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:difficulty running or inability to run n1=en:muscle weakness begins proximally | n2=en:difficulty running or inability to run | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:difficulty walking and climbing stairs (patient a) n1=en:muscle weakness begins proximally | n2=en:difficulty walking and climbing stairs (patient a) | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:difficulty walking on heels occurs prior to difficulty walking on toes n1=en:muscle weakness begins proximally | n2=en:difficulty walking on heels occurs prior to difficulty walking on toes | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:difficulty walking, running, climbing stairs n1=en:muscle weakness begins proximally | n2=en:difficulty walking, running, climbing stairs | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:disarray of mitochondrial cristae seen on muscle biopsy n1=en:muscle weakness begins proximally | n2=en:disarray of mitochondrial cristae seen on muscle biopsy | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:disorganization of the myofibrillar pattern n1=en:muscle weakness begins proximally | n2=en:disorganization of the myofibrillar pattern | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:disorganization of the neuromuscular junction n1=en:muscle weakness begins proximally | n2=en:disorganization of the neuromuscular junction | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:distal atrophy of the legs n1=en:muscle weakness begins proximally | n2=en:distal atrophy of the legs | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:distal leg muscle atrophy n1=en:muscle weakness begins proximally | n2=en:distal leg muscle atrophy | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:distal limb muscle atrophy (less common) n1=en:muscle weakness begins proximally | n2=en:distal limb muscle atrophy (less common) | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:distal limb muscle weakness (less common) n1=en:muscle weakness begins proximally | n2=en:distal limb muscle weakness (less common) | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:distal limb muscle weakness and atrophy n1=en:muscle weakness begins proximally | n2=en:distal limb muscle weakness and atrophy | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:distal limb muscle weakness occurs later n1=en:muscle weakness begins proximally | n2=en:distal limb muscle weakness occurs later | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:distal lower limb amyotrophy n1=en:muscle weakness begins proximally | n2=en:distal lower limb amyotrophy | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:distal lower limb muscle weakness and atrophy n1=en:muscle weakness begins proximally | n2=en:distal lower limb muscle weakness and atrophy | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:distal muscle atrophy (lower limbs more affected than upper limbs) n1=en:muscle weakness begins proximally | n2=en:distal muscle atrophy (lower limbs more affected than upper limbs) | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:distal muscle atrophy due to denervation n1=en:muscle weakness begins proximally | n2=en:distal muscle atrophy due to denervation | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:distal muscle atrophy due to neurologic disease n1=en:muscle weakness begins proximally | n2=en:distal muscle atrophy due to neurologic disease | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:distal muscle atrophy due to neuropathy n1=en:muscle weakness begins proximally | n2=en:distal muscle atrophy due to neuropathy | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:distal muscle atrophy, affecting the lower limbs n1=en:muscle weakness begins proximally | n2=en:distal muscle atrophy, affecting the lower limbs | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:distal muscle weakness (first affects anterior leg muscles, then posterior leg muscles) n1=en:muscle weakness begins proximally | n2=en:distal muscle weakness (first affects anterior leg muscles, then posterior leg muscles) | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:distal muscle weakness and atrophy n1=en:muscle weakness begins proximally | n2=en:distal muscle weakness and atrophy | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:distal muscle weakness and atrophy may occur, upper and lower limbs affected n1=en:muscle weakness begins proximally | n2=en:distal muscle weakness and atrophy may occur, upper and lower limbs affected | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:distal muscle weakness due to neuropathy n1=en:muscle weakness begins proximally | n2=en:distal muscle weakness due to neuropathy | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:distal muscle weakness due to peripheral neuropathy, lower limbs more affected than upper limbs n1=en:muscle weakness begins proximally | n2=en:distal muscle weakness due to peripheral neuropathy, lower limbs more affected than upper limbs | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:distal muscle weakness in lower limbs, severe n1=en:muscle weakness begins proximally | n2=en:distal muscle weakness in lower limbs, severe | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:distal muscle weakness may occur n1=en:muscle weakness begins proximally | n2=en:distal muscle weakness may occur | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:distal muscle weakness occurs later n1=en:muscle weakness begins proximally | n2=en:distal muscle weakness occurs later | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:distal muscle weakness of the lower limbs secondary to peripheral neuropathy n1=en:muscle weakness begins proximally | n2=en:distal muscle weakness of the lower limbs secondary to peripheral neuropathy | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:distal muscle weakness, affecting the lower limbs n1=en:muscle weakness begins proximally | n2=en:distal muscle weakness, affecting the lower limbs | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:distal muscle weakness, lower legs n1=en:muscle weakness begins proximally | n2=en:distal muscle weakness, lower legs | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:distal muscle weakness, mild n1=en:muscle weakness begins proximally | n2=en:distal muscle weakness, mild | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:distal muscle weakness, occurs initially n1=en:muscle weakness begins proximally | n2=en:distal muscle weakness, occurs initially | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:distal muscles may be affected n1=en:muscle weakness begins proximally | n2=en:distal muscles may be affected | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:distal upper limb amyotrophy n1=en:muscle weakness begins proximally | n2=en:distal upper limb amyotrophy | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:distal upper limb muscle weakness n1=en:muscle weakness begins proximally | n2=en:distal upper limb muscle weakness | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:distal weakness, upper and lower limbs (variable) n1=en:muscle weakness begins proximally | n2=en:distal weakness, upper and lower limbs (variable) | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:dorsal and flexor muscles of the forearm are involved n1=en:muscle weakness begins proximally | n2=en:dorsal and flexor muscles of the forearm are involved | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:dystrophic changes n1=en:muscle weakness begins proximally | n2=en:dystrophic changes | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:dystrophic changes may be present n1=en:muscle weakness begins proximally | n2=en:dystrophic changes may be present | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:dystrophic changes occur later n1=en:muscle weakness begins proximally | n2=en:dystrophic changes occur later | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:dystrophic changes on biopsy n1=en:muscle weakness begins proximally | n2=en:dystrophic changes on biopsy | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:dystrophic changes seen on muscle biopsy n1=en:muscle weakness begins proximally | n2=en:dystrophic changes seen on muscle biopsy | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:dystrophic changes seen on skeletal muscle biopsy n1=en:muscle weakness begins proximally | n2=en:dystrophic changes seen on skeletal muscle biopsy | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:dystrophic features n1=en:muscle weakness begins proximally | n2=en:dystrophic features | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:easy bruisability of lower extremities n1=en:muscle weakness begins proximally | n2=en:easy bruisability of lower extremities | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:edema (hands and feet) n1=en:muscle weakness begins proximally | n2=en:edema (hands and feet) | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:edema at birth n1=en:muscle weakness begins proximally | n2=en:edema at birth | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:edema is present at birth and then slowly decreases n1=en:muscle weakness begins proximally | n2=en:edema is present at birth and then slowly decreases | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:edema reoccurs with infections n1=en:muscle weakness begins proximally | n2=en:edema reoccurs with infections | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:edema, subcutaneous, generalized n1=en:muscle weakness begins proximally | n2=en:edema, subcutaneous, generalized | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:electromyographic decrements in some muscles n1=en:muscle weakness begins proximally | n2=en:electromyographic decrements in some muscles | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:electromyography shows myotonic discharges n1=en:muscle weakness begins proximally | n2=en:electromyography shows myotonic discharges | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:electron microscopy shows abnormal mitochondria with disorganized and vacuolated cristae n1=en:muscle weakness begins proximally | n2=en:electron microscopy shows abnormal mitochondria with disorganized and vacuolated cristae | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:electron microscopy shows subsarcolemmal accumulations of abnormally shaped mitochondria n1=en:muscle weakness begins proximally | n2=en:electron microscopy shows subsarcolemmal accumulations of abnormally shaped mitochondria | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:endomysial fibrosis n1=en:muscle weakness begins proximally | n2=en:endomysial fibrosis | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:endplate myopathy n1=en:muscle weakness begins proximally | n2=en:endplate myopathy | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:enlarged mitochondria n1=en:muscle weakness begins proximally | n2=en:enlarged mitochondria | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:eosinophilic inclusions n1=en:muscle weakness begins proximally | n2=en:eosinophilic inclusions | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:episodic weakness may or may not occur independent of myotonia n1=en:muscle weakness begins proximally | n2=en:episodic weakness may or may not occur independent of myotonia | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:episodic, nonpruritic, nonurticarial, nonpitting edema n1=en:muscle weakness begins proximally | n2=en:episodic, nonpruritic, nonurticarial, nonpitting edema | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:excess fat, symmetrically located in buttocks and lower extremities to ankles n1=en:muscle weakness begins proximally | n2=en:excess fat, symmetrically located in buttocks and lower extremities to ankles | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:exercise intolerance (also seen in some heterozygotes) n1=en:muscle weakness begins proximally | n2=en:exercise intolerance (also seen in some heterozygotes) | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:exercise intolerance (less common) n1=en:muscle weakness begins proximally | n2=en:exercise intolerance (less common) | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:exercise-induced muscle fatigue n1=en:muscle weakness begins proximally | n2=en:exercise-induced muscle fatigue | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:exercise-induced muscle stiffness n1=en:muscle weakness begins proximally | n2=en:exercise-induced muscle stiffness | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:exercise-induced weakness n1=en:muscle weakness begins proximally | n2=en:exercise-induced weakness | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:exertional fatigue n1=en:muscle weakness begins proximally | n2=en:exertional fatigue | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:extensor muscle weakness more severe than flexor muscle weakness n1=en:muscle weakness begins proximally | n2=en:extensor muscle weakness more severe than flexor muscle weakness | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:facial muscle weakness and atrophy, progressive n1=en:muscle weakness begins proximally | n2=en:facial muscle weakness and atrophy, progressive | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:fasciculations (less common) n1=en:muscle weakness begins proximally | n2=en:fasciculations (less common) | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:fat droplets in sarcoplasm and mitochondria seen on skeletal muscle biopsy n1=en:muscle weakness begins proximally | n2=en:fat droplets in sarcoplasm and mitochondria seen on skeletal muscle biopsy | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:fat pad anterior to malleolus n1=en:muscle weakness begins proximally | n2=en:fat pad anterior to malleolus | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:fatty infiltration of affected muscles n1=en:muscle weakness begins proximally | n2=en:fatty infiltration of affected muscles | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:fatty replacement n1=en:muscle weakness begins proximally | n2=en:fatty replacement | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:fiber necrosis n1=en:muscle weakness begins proximally | n2=en:fiber necrosis | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:fiber size variation n1=en:muscle weakness begins proximally | n2=en:fiber size variation | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:fiber size variation seen on muscle biopsy n1=en:muscle weakness begins proximally | n2=en:fiber size variation seen on muscle biopsy | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:fiber type grouping n1=en:muscle weakness begins proximally | n2=en:fiber type grouping | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:fiber type variation n1=en:muscle weakness begins proximally | n2=en:fiber type variation | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:fibrillations in affected muscles n1=en:muscle weakness begins proximally | n2=en:fibrillations in affected muscles | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:finger and wrist extensor weakness n1=en:muscle weakness begins proximally | n2=en:finger and wrist extensor weakness | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:firm muscles n1=en:muscle weakness begins proximally | n2=en:firm muscles | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:flaccid weakness or paralysis, episodic attacks n1=en:muscle weakness begins proximally | n2=en:flaccid weakness or paralysis, episodic attacks | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:focal loss of cross striations seen on muscle biopsy n1=en:muscle weakness begins proximally | n2=en:focal loss of cross striations seen on muscle biopsy | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:foot dorsiflexor weakness n1=en:muscle weakness begins proximally | n2=en:foot dorsiflexor weakness | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:foot extensor muscle weakness (later onset) n1=en:muscle weakness begins proximally | n2=en:foot extensor muscle weakness (later onset) | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:gait abnormalities (occurs later) n1=en:muscle weakness begins proximally | n2=en:gait abnormalities (occurs later) | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:gastrocnemius and soleus muscles most affected n1=en:muscle weakness begins proximally | n2=en:gastrocnemius and soleus muscles most affected | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:generalized amyoplasia n1=en:muscle weakness begins proximally | n2=en:generalized amyoplasia | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:generalized lack of subcutaneous fat n1=en:muscle weakness begins proximally | n2=en:generalized lack of subcutaneous fat | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:generalized limb muscle atrophy n1=en:muscle weakness begins proximally | n2=en:generalized limb muscle atrophy | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:generalized muscle wasting n1=en:muscle weakness begins proximally | n2=en:generalized muscle wasting | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:generalized muscle weakness (less common) n1=en:muscle weakness begins proximally | n2=en:generalized muscle weakness (less common) | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:generalized muscle weakness, proximal and distal n1=en:muscle weakness begins proximally | n2=en:generalized muscle weakness, proximal and distal | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:generalized muscle weakness, severe n1=en:muscle weakness begins proximally | n2=en:generalized muscle weakness, severe | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:generalized muscular appearance from birth n1=en:muscle weakness begins proximally | n2=en:generalized muscular appearance from birth | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:generalized neonatal hypotonia n1=en:muscle weakness begins proximally | n2=en:generalized neonatal hypotonia | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:gluteal hypoplasia n1=en:muscle weakness begins proximally | n2=en:gluteal hypoplasia | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:gluteus maximus and thigh adductors most affected n1=en:muscle weakness begins proximally | n2=en:gluteus maximus and thigh adductors most affected | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:glycogen depletion in skeletal muscle n1=en:muscle weakness begins proximally | n2=en:glycogen depletion in skeletal muscle | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:glycogenosis of skeletal muscle, mild (in some patients) n1=en:muscle weakness begins proximally | n2=en:glycogenosis of skeletal muscle, mild (in some patients) | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:granular deposits in the sarcomeres n1=en:muscle weakness begins proximally | n2=en:granular deposits in the sarcomeres | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:hamstring and quadriceps muscles mildly affected n1=en:muscle weakness begins proximally | n2=en:hamstring and quadriceps muscles mildly affected | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:hamstring muscle affected n1=en:muscle weakness begins proximally | n2=en:hamstring muscle affected | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:hand and foot weakness n1=en:muscle weakness begins proximally | n2=en:hand and foot weakness | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:handgrip myotonia n1=en:muscle weakness begins proximally | n2=en:handgrip myotonia | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:hangrip myotonia n1=en:muscle weakness begins proximally | n2=en:hangrip myotonia | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:heterotopic bone formation in subcutaneous fat n1=en:muscle weakness begins proximally | n2=en:heterotopic bone formation in subcutaneous fat | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:hip abductor weakness and atrophy n1=en:muscle weakness begins proximally | n2=en:hip abductor weakness and atrophy | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:hip flexor weakness n1=en:muscle weakness begins proximally | n2=en:hip flexor weakness | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:hip girdle muscle atrophy n1=en:muscle weakness begins proximally | n2=en:hip girdle muscle atrophy | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:hip girdle muscle weakness (usually presenting symptom) n1=en:muscle weakness begins proximally | n2=en:hip girdle muscle weakness (usually presenting symptom) | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:humeroperoneal weakness and atrophy n1=en:muscle weakness begins proximally | n2=en:humeroperoneal weakness and atrophy | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:hyaline inclusion n1=en:muscle weakness begins proximally | n2=en:hyaline inclusion | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:hyaline plaques with absent oxidative activity n1=en:muscle weakness begins proximally | n2=en:hyaline plaques with absent oxidative activity | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:hypertonia at birth n1=en:muscle weakness begins proximally | n2=en:hypertonia at birth | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:hypertrophy of calves (in 3 of 6 patients) n1=en:muscle weakness begins proximally | n2=en:hypertrophy of calves (in 3 of 6 patients) | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:hypertrophy of the extensor digitorum brevis muscles n1=en:muscle weakness begins proximally | n2=en:hypertrophy of the extensor digitorum brevis muscles | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:hypoglycosylation of alpha-dystroglycan seen on muscle biopsy n1=en:muscle weakness begins proximally | n2=en:hypoglycosylation of alpha-dystroglycan seen on muscle biopsy | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:hypoplasia of cervical paravertebral muscles n1=en:muscle weakness begins proximally | n2=en:hypoplasia of cervical paravertebral muscles | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:hypoplasia of serratus anterior muscle n1=en:muscle weakness begins proximally | n2=en:hypoplasia of serratus anterior muscle | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:hypoplasia of supraspinatus muscle n1=en:muscle weakness begins proximally | n2=en:hypoplasia of supraspinatus muscle | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:hypoplasia of the hand muscles (29%) n1=en:muscle weakness begins proximally | n2=en:hypoplasia of the hand muscles (29%) | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:hyporeflexia in affected muscles n1=en:muscle weakness begins proximally | n2=en:hyporeflexia in affected muscles | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:hypothenar muscle atrophy n1=en:muscle weakness begins proximally | n2=en:hypothenar muscle atrophy | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:hypotonia (2 patients) n1=en:muscle weakness begins proximally | n2=en:hypotonia (2 patients) | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:hypotonia (45%) n1=en:muscle weakness begins proximally | n2=en:hypotonia (45%) | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:hypotonia (families a and b) n1=en:muscle weakness begins proximally | n2=en:hypotonia (families a and b) | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:hypotonia (patients a and c) n1=en:muscle weakness begins proximally | n2=en:hypotonia (patients a and c) | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:hypotonia (untreated hypothyroidism) n1=en:muscle weakness begins proximally | n2=en:hypotonia (untreated hypothyroidism) | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:hypotonia, generalized, severe n1=en:muscle weakness begins proximally | n2=en:hypotonia, generalized, severe | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:hypotonia, neonatal and later n1=en:muscle weakness begins proximally | n2=en:hypotonia, neonatal and later | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:hypotonia, neonatal, severe (hcs) n1=en:muscle weakness begins proximally | n2=en:hypotonia, neonatal, severe (hcs) | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:hypotonia, profound n1=en:muscle weakness begins proximally | n2=en:hypotonia, profound | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:hypotonia, truncal and appendicular n1=en:muscle weakness begins proximally | n2=en:hypotonia, truncal and appendicular | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:hypotrophy of type 1 fibers n1=en:muscle weakness begins proximally | n2=en:hypotrophy of type 1 fibers | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:imaging shows muscle atrophy and fatty replacement n1=en:muscle weakness begins proximally | n2=en:imaging shows muscle atrophy and fatty replacement | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:imaging shows progressive fatty infiltration of muscle n1=en:muscle weakness begins proximally | n2=en:imaging shows progressive fatty infiltration of muscle | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:inability to jump or squat n1=en:muscle weakness begins proximally | n2=en:inability to jump or squat | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:inability to stand on tiptoes n1=en:muscle weakness begins proximally | n2=en:inability to stand on tiptoes | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:inability to stand or walk (in severe cases) n1=en:muscle weakness begins proximally | n2=en:inability to stand or walk (in severe cases) | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:inclusion body myopathy n1=en:muscle weakness begins proximally | n2=en:inclusion body myopathy | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:increased adipose fibrosis n1=en:muscle weakness begins proximally | n2=en:increased adipose fibrosis | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:increased central nucleation n1=en:muscle weakness begins proximally | n2=en:increased central nucleation | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:increased centralized internal nuclei n1=en:muscle weakness begins proximally | n2=en:increased centralized internal nuclei | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:increased connective tissue n1=en:muscle weakness begins proximally | n2=en:increased connective tissue | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:increased connective tissue and fat n1=en:muscle weakness begins proximally | n2=en:increased connective tissue and fat | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:increased connective tissue and fat in muscles n1=en:muscle weakness begins proximally | n2=en:increased connective tissue and fat in muscles | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:increased endo- and perimysial connective tissue n1=en:muscle weakness begins proximally | n2=en:increased endo- and perimysial connective tissue | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:increased endomysial connective tissue around muscle fibers n1=en:muscle weakness begins proximally | n2=en:increased endomysial connective tissue around muscle fibers | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:increased fatigue n1=en:muscle weakness begins proximally | n2=en:increased fatigue | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:increased fatty and connective tissue in skeletal muscle n1=en:muscle weakness begins proximally | n2=en:increased fatty and connective tissue in skeletal muscle | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:increased fatty infiltration n1=en:muscle weakness begins proximally | n2=en:increased fatty infiltration | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:increased fibrosis (family a) n1=en:muscle weakness begins proximally | n2=en:increased fibrosis (family a) | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:increased fibrosis (in some patients) n1=en:muscle weakness begins proximally | n2=en:increased fibrosis (in some patients) | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:increased glycogen n1=en:muscle weakness begins proximally | n2=en:increased glycogen | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:increased glycogen in muscle (but to a lesser extent than in the heart) n1=en:muscle weakness begins proximally | n2=en:increased glycogen in muscle (but to a lesser extent than in the heart) | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:increased internal nuclei n1=en:muscle weakness begins proximally | n2=en:increased internal nuclei | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:increased internal nuclei (in some patients) n1=en:muscle weakness begins proximally | n2=en:increased internal nuclei (in some patients) | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:increased internal nuclei in skeletal muscle fibers n1=en:muscle weakness begins proximally | n2=en:increased internal nuclei in skeletal muscle fibers | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:increased intraabdominal fat n1=en:muscle weakness begins proximally | n2=en:increased intraabdominal fat | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:increased intramuscular fat n1=en:muscle weakness begins proximally | n2=en:increased intramuscular fat | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:increased length of endplate regions seen on muscle biopsy n1=en:muscle weakness begins proximally | n2=en:increased length of endplate regions seen on muscle biopsy | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:increased lipid droplets and abnormal mitochondria n1=en:muscle weakness begins proximally | n2=en:increased lipid droplets and abnormal mitochondria | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:increased lysosomal glycogen n1=en:muscle weakness begins proximally | n2=en:increased lysosomal glycogen | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:increased muscle glycogen content n1=en:muscle weakness begins proximally | n2=en:increased muscle glycogen content | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:increased muscle lipid content n1=en:muscle weakness begins proximally | n2=en:increased muscle lipid content | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:increased numbers of type 1 fibers n1=en:muscle weakness begins proximally | n2=en:increased numbers of type 1 fibers | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:increased perisarcolemmal calcium deposition n1=en:muscle weakness begins proximally | n2=en:increased perisarcolemmal calcium deposition | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:increased staining for myotilin, dystrophin, desmin n1=en:muscle weakness begins proximally | n2=en:increased staining for myotilin, dystrophin, desmin | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:increased subcutaneous truncal adipose tissue n1=en:muscle weakness begins proximally | n2=en:increased subcutaneous truncal adipose tissue | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:increased variability in muscle fiber diameter n1=en:muscle weakness begins proximally | n2=en:increased variability in muscle fiber diameter | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:increased variation in fiber size (in some patients) n1=en:muscle weakness begins proximally | n2=en:increased variation in fiber size (in some patients) | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:increased variation in fiber size seen on muscle biopsy n1=en:muscle weakness begins proximally | n2=en:increased variation in fiber size seen on muscle biopsy | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:increased variation in muscle fiber diameter n1=en:muscle weakness begins proximally | n2=en:increased variation in muscle fiber diameter | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:indentations or folds of the sarcolemma are connected to the membranes enclosing the vacuoles n1=en:muscle weakness begins proximally | n2=en:indentations or folds of the sarcolemma are connected to the membranes enclosing the vacuoles | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:independent walking may not be achieved n1=en:muscle weakness begins proximally | n2=en:independent walking may not be achieved | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:inflammatory cells absent n1=en:muscle weakness begins proximally | n2=en:inflammatory cells absent | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:interfibrillar and subsarcolemmal vacuoles n1=en:muscle weakness begins proximally | n2=en:interfibrillar and subsarcolemmal vacuoles | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:intermyofibrillar and subsarcolemmal granulofilamentous protein aggregates n1=en:muscle weakness begins proximally | n2=en:intermyofibrillar and subsarcolemmal granulofilamentous protein aggregates | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:internal nuclei n1=en:muscle weakness begins proximally | n2=en:internal nuclei | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:internal nuclei (in some patients) n1=en:muscle weakness begins proximally | n2=en:internal nuclei (in some patients) | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:interosseus muscles involved n1=en:muscle weakness begins proximally | n2=en:interosseus muscles involved | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:intrasarcoplasmic dense granulofilamentous aggregates that are immunoreactive with desmin n1=en:muscle weakness begins proximally | n2=en:intrasarcoplasmic dense granulofilamentous aggregates that are immunoreactive with desmin | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:involves upper and lower proximal muscles n1=en:muscle weakness begins proximally | n2=en:involves upper and lower proximal muscles | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:lack of antigravity movements (patient b) n1=en:muscle weakness begins proximally | n2=en:lack of antigravity movements (patient b) | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:lafora bodies (accumulation of polyglucosan) seen on skeletal muscle biopsy n1=en:muscle weakness begins proximally | n2=en:lafora bodies (accumulation of polyglucosan) seen on skeletal muscle biopsy | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:large hypertrophied fibers n1=en:muscle weakness begins proximally | n2=en:large hypertrophied fibers | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:large lipid droplets n1=en:muscle weakness begins proximally | n2=en:large lipid droplets | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:leg cramps may occur with exercise n1=en:muscle weakness begins proximally | n2=en:leg cramps may occur with exercise | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:levator palpebrae superioris atrophy n1=en:muscle weakness begins proximally | n2=en:levator palpebrae superioris atrophy | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:limb muscle weakness, proximal, upper and lower n1=en:muscle weakness begins proximally | n2=en:limb muscle weakness, proximal, upper and lower | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:limb weakness and atrophy n1=en:muscle weakness begins proximally | n2=en:limb weakness and atrophy | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:limb-girdle muscle atrophy n1=en:muscle weakness begins proximally | n2=en:limb-girdle muscle atrophy | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:limb-girdle muscle weakness, proximal, upper greater than lower n1=en:muscle weakness begins proximally | n2=en:limb-girdle muscle weakness, proximal, upper greater than lower | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:limb-girdle myopathy n1=en:muscle weakness begins proximally | n2=en:limb-girdle myopathy | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:lipid droplet accumulation n1=en:muscle weakness begins proximally | n2=en:lipid droplet accumulation | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:lipid storage, mainly in type i fibers n1=en:muscle weakness begins proximally | n2=en:lipid storage, mainly in type i fibers | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:lipoatrophy (lower face, upper limb, buttock) n1=en:muscle weakness begins proximally | n2=en:lipoatrophy (lower face, upper limb, buttock) | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:lipoatrophy of trunk n1=en:muscle weakness begins proximally | n2=en:lipoatrophy of trunk | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:lipoatrophy, generalized n1=en:muscle weakness begins proximally | n2=en:lipoatrophy, generalized | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:lipodystrophy (in some patients) n1=en:muscle weakness begins proximally | n2=en:lipodystrophy (in some patients) | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:lipodystrophy, generalized, panniculitis-induced (in some) n1=en:muscle weakness begins proximally | n2=en:lipodystrophy, generalized, panniculitis-induced (in some) | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:lipohypoplasia, regional n1=en:muscle weakness begins proximally | n2=en:lipohypoplasia, regional | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:lipomas or lipomatous masses (most cases) n1=en:muscle weakness begins proximally | n2=en:lipomas or lipomatous masses (most cases) | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:loss of ability to walk in early childhood n1=en:muscle weakness begins proximally | n2=en:loss of ability to walk in early childhood | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:loss of adipose tissue occurs around puberty n1=en:muscle weakness begins proximally | n2=en:loss of adipose tissue occurs around puberty | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:loss of ambulation n1=en:muscle weakness begins proximally | n2=en:loss of ambulation | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:loss of ambulation between third and sixth decade n1=en:muscle weakness begins proximally | n2=en:loss of ambulation between third and sixth decade | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:loss of antigravity strength n1=en:muscle weakness begins proximally | n2=en:loss of antigravity strength | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:loss of gluteal adipose tissue n1=en:muscle weakness begins proximally | n2=en:loss of gluteal adipose tissue | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:loss of independent ambulation around age 12 years n1=en:muscle weakness begins proximally | n2=en:loss of independent ambulation around age 12 years | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:loss of subcutaneous adipose tissue from gluteal region n1=en:muscle weakness begins proximally | n2=en:loss of subcutaneous adipose tissue from gluteal region | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:loss of subcutaneous adipose tissue from upper limbs and trunk n1=en:muscle weakness begins proximally | n2=en:loss of subcutaneous adipose tissue from upper limbs and trunk | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:loss of subcutaneous adipose tissue in limbs n1=en:muscle weakness begins proximally | n2=en:loss of subcutaneous adipose tissue in limbs | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:loss of subcutaneous adipose tissue primarily in gluteal region and lower limbs n1=en:muscle weakness begins proximally | n2=en:loss of subcutaneous adipose tissue primarily in gluteal region and lower limbs | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:loss of subcutaneous fat, generalized n1=en:muscle weakness begins proximally | n2=en:loss of subcutaneous fat, generalized | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:loss of truncal subcutaneous adipose tissue n1=en:muscle weakness begins proximally | n2=en:loss of truncal subcutaneous adipose tissue | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:low muscle mass n1=en:muscle weakness begins proximally | n2=en:low muscle mass | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:lymphangitis, episodic n1=en:muscle weakness begins proximally | n2=en:lymphangitis, episodic | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:lymphedema (lower limb) n1=en:muscle weakness begins proximally | n2=en:lymphedema (lower limb) | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:lymphedema (primarily in lower limbs, but also arms in some patients) n1=en:muscle weakness begins proximally | n2=en:lymphedema (primarily in lower limbs, but also arms in some patients) | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:lymphedema of the extremities n1=en:muscle weakness begins proximally | n2=en:lymphedema of the extremities | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:lymphedema of the hands (in some patients) n1=en:muscle weakness begins proximally | n2=en:lymphedema of the hands (in some patients) | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:lymphedema of the lower limbs (swelling is confined to below the knees) n1=en:muscle weakness begins proximally | n2=en:lymphedema of the lower limbs (swelling is confined to below the knees) | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:lymphedema, dorsa of feet n1=en:muscle weakness begins proximally | n2=en:lymphedema, dorsa of feet | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:lymphedema, hands (rare) n1=en:muscle weakness begins proximally | n2=en:lymphedema, hands (rare) | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:lymphedema, of upper and/or lower extremity (rare) n1=en:muscle weakness begins proximally | n2=en:lymphedema, of upper and/or lower extremity (rare) | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:lymphography shows hypoplasia of lymphatic vessels n1=en:muscle weakness begins proximally | n2=en:lymphography shows hypoplasia of lymphatic vessels | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:lymphography shows increased number of dilated lymphatic vessels (hyperplasia) n1=en:muscle weakness begins proximally | n2=en:lymphography shows increased number of dilated lymphatic vessels (hyperplasia) | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:mallory-like bodies n1=en:muscle weakness begins proximally | n2=en:mallory-like bodies | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:marked lack of adipose tissue n1=en:muscle weakness begins proximally | n2=en:marked lack of adipose tissue | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:marked loss of subcutaneous fat in the limbs, face, and sometimes chest n1=en:muscle weakness begins proximally | n2=en:marked loss of subcutaneous fat in the limbs, face, and sometimes chest | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:marked muscular hypertrophy n1=en:muscle weakness begins proximally | n2=en:marked muscular hypertrophy | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:marked predominance of slow-twitch, oxidative (type 1) muscle fibers n1=en:muscle weakness begins proximally | n2=en:marked predominance of slow-twitch, oxidative (type 1) muscle fibers | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:merosin-positive biopsy n1=en:muscle weakness begins proximally | n2=en:merosin-positive biopsy | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:mild endplate myopathy n1=en:muscle weakness begins proximally | n2=en:mild endplate myopathy | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:mild kinetic abnormalities of the achr (in some patients) n1=en:muscle weakness begins proximally | n2=en:mild kinetic abnormalities of the achr (in some patients) | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:mild muscle atrophy in forearm muscles n1=en:muscle weakness begins proximally | n2=en:mild muscle atrophy in forearm muscles | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:mild variability in muscle fiber size n1=en:muscle weakness begins proximally | n2=en:mild variability in muscle fiber size | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:mild weakness n1=en:muscle weakness begins proximally | n2=en:mild weakness | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:mild weakness of the small hand muscles n1=en:muscle weakness begins proximally | n2=en:mild weakness of the small hand muscles | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:mildly increased mtdna n1=en:muscle weakness begins proximally | n2=en:mildly increased mtdna | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:minicore regions are poorly defined and do not extend through entire fiber length n1=en:muscle weakness begins proximally | n2=en:minicore regions are poorly defined and do not extend through entire fiber length | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:minicore-like lesions with mitochondrial depletion and sarcomeric disorganization n1=en:muscle weakness begins proximally | n2=en:minicore-like lesions with mitochondrial depletion and sarcomeric disorganization | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:minicores extend full fiber diameter n1=en:muscle weakness begins proximally | n2=en:minicores extend full fiber diameter | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:minimal muscle mass n1=en:muscle weakness begins proximally | n2=en:minimal muscle mass | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:minimal subcutaneous fat n1=en:muscle weakness begins proximally | n2=en:minimal subcutaneous fat | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:minipolymyoclonus n1=en:muscle weakness begins proximally | n2=en:minipolymyoclonus | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:mitochondria are placed at the periphery of muscle fibers n1=en:muscle weakness begins proximally | n2=en:mitochondria are placed at the periphery of muscle fibers | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:mitochondria show paracrystalline inclusions n1=en:muscle weakness begins proximally | n2=en:mitochondria show paracrystalline inclusions | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:mitochondrial paracrystalline inclusion bodies n1=en:muscle weakness begins proximally | n2=en:mitochondrial paracrystalline inclusion bodies | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:mitochondrial proliferation n1=en:muscle weakness begins proximally | n2=en:mitochondrial proliferation | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:motor clumsiness n1=en:muscle weakness begins proximally | n2=en:motor clumsiness | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:muscle aches, intermittent n1=en:muscle weakness begins proximally | n2=en:muscle aches, intermittent | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:muscle atrophy (variable) n1=en:muscle weakness begins proximally | n2=en:muscle atrophy (variable) | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:muscle atrophy affecting the upper back and neck muscles n1=en:muscle weakness begins proximally | n2=en:muscle atrophy affecting the upper back and neck muscles | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:muscle atrophy appears later in disease course n1=en:muscle weakness begins proximally | n2=en:muscle atrophy appears later in disease course | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:muscle atrophy in the limbs n1=en:muscle weakness begins proximally | n2=en:muscle atrophy in the limbs | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:muscle atrophy later in the disease n1=en:muscle weakness begins proximally | n2=en:muscle atrophy later in the disease | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:muscle atrophy restricted to the upper limb n1=en:muscle weakness begins proximally | n2=en:muscle atrophy restricted to the upper limb | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:muscle atrophy, especially quadriceps and forearm muscles n1=en:muscle weakness begins proximally | n2=en:muscle atrophy, especially quadriceps and forearm muscles | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:muscle atrophy, limb-girdle and proximal n1=en:muscle weakness begins proximally | n2=en:muscle atrophy, limb-girdle and proximal | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:muscle atrophy, lower limbs more affected than upper limbs n1=en:muscle weakness begins proximally | n2=en:muscle atrophy, lower limbs more affected than upper limbs | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:muscle atrophy, mild, more proximal than distal n1=en:muscle weakness begins proximally | n2=en:muscle atrophy, mild, more proximal than distal | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:muscle atrophy, progressive n1=en:muscle weakness begins proximally | n2=en:muscle atrophy, progressive | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:muscle atrophy, upper and lower limbs n1=en:muscle weakness begins proximally | n2=en:muscle atrophy, upper and lower limbs | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:muscle biopsy in acute stage shows increased numbers of abnormal mitochondria n1=en:muscle weakness begins proximally | n2=en:muscle biopsy in acute stage shows increased numbers of abnormal mitochondria | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:muscle biopsy is immunopositive for merosin (156225) n1=en:muscle weakness begins proximally | n2=en:muscle biopsy is immunopositive for merosin (156225) | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:muscle biopsy may show inflammatory changes n1=en:muscle weakness begins proximally | n2=en:muscle biopsy may show inflammatory changes | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:muscle biopsy shows 60-80-nm tubular aggregates arranged in hexagonal arrays in type 2 fibers n1=en:muscle weakness begins proximally | n2=en:muscle biopsy shows 60-80-nm tubular aggregates arranged in hexagonal arrays in type 2 fibers | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:muscle biopsy shows abnormal fiber size and variation n1=en:muscle weakness begins proximally | n2=en:muscle biopsy shows abnormal fiber size and variation | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:muscle biopsy shows abnormal mitochondria n1=en:muscle weakness begins proximally | n2=en:muscle biopsy shows abnormal mitochondria | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:muscle biopsy shows centralized nuclei n1=en:muscle weakness begins proximally | n2=en:muscle biopsy shows centralized nuclei | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:muscle biopsy shows chronic and active denervation n1=en:muscle weakness begins proximally | n2=en:muscle biopsy shows chronic and active denervation | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:muscle biopsy shows core-like regions devoid of oxidative activity n1=en:muscle weakness begins proximally | n2=en:muscle biopsy shows core-like regions devoid of oxidative activity | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:muscle biopsy shows decrease or absence of cytochrome c oxidase n1=en:muscle weakness begins proximally | n2=en:muscle biopsy shows decrease or absence of cytochrome c oxidase | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:muscle biopsy shows decreased activity of cytochrome c oxidase n1=en:muscle weakness begins proximally | n2=en:muscle biopsy shows decreased activity of cytochrome c oxidase | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:muscle biopsy shows decreased muscle-specific phosphorylase kinase activity n1=en:muscle weakness begins proximally | n2=en:muscle biopsy shows decreased muscle-specific phosphorylase kinase activity | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:muscle biopsy shows decreased or absent dysferlin staining n1=en:muscle weakness begins proximally | n2=en:muscle biopsy shows decreased or absent dysferlin staining | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:muscle biopsy shows degenerating endplates and junctional folds n1=en:muscle weakness begins proximally | n2=en:muscle biopsy shows degenerating endplates and junctional folds | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:muscle biopsy shows degeneration of muscle fibers, variation in fiber size, fiber splitting, rimmed vacuoles, and central myonuclei n1=en:muscle weakness begins proximally | n2=en:muscle biopsy shows degeneration of muscle fibers, variation in fiber size, fiber splitting, rimmed vacuoles, and central myonuclei | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:muscle biopsy shows disruption of the sarcolemmal membrane n1=en:muscle weakness begins proximally | n2=en:muscle biopsy shows disruption of the sarcolemmal membrane | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:muscle biopsy shows dystrophic changes n1=en:muscle weakness begins proximally | n2=en:muscle biopsy shows dystrophic changes | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:muscle biopsy shows dystrophic features n1=en:muscle weakness begins proximally | n2=en:muscle biopsy shows dystrophic features | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:muscle biopsy shows dystrophic pattern n1=en:muscle weakness begins proximally | n2=en:muscle biopsy shows dystrophic pattern | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:muscle biopsy shows fiber type disproportion n1=en:muscle weakness begins proximally | n2=en:muscle biopsy shows fiber type disproportion | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:muscle biopsy shows fibrosis and increased connective tissue n1=en:muscle weakness begins proximally | n2=en:muscle biopsy shows fibrosis and increased connective tissue | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:muscle biopsy shows glycogen accumulation in myofibrils and lysosomes n1=en:muscle weakness begins proximally | n2=en:muscle biopsy shows glycogen accumulation in myofibrils and lysosomes | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:muscle biopsy shows glycogen storage n1=en:muscle weakness begins proximally | n2=en:muscle biopsy shows glycogen storage | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:muscle biopsy shows hypotrophy of type 1 muscle fibers n1=en:muscle weakness begins proximally | n2=en:muscle biopsy shows hypotrophy of type 1 muscle fibers | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:muscle biopsy shows increased subsarcolemmal vacuolar glycogen accumulation n1=en:muscle weakness begins proximally | n2=en:muscle biopsy shows increased subsarcolemmal vacuolar glycogen accumulation | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:muscle biopsy shows increased variation in fiber size n1=en:muscle weakness begins proximally | n2=en:muscle biopsy shows increased variation in fiber size | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:muscle biopsy shows intranuclear tubulofilamentous inclusions n1=en:muscle weakness begins proximally | n2=en:muscle biopsy shows intranuclear tubulofilamentous inclusions | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:muscle biopsy shows lipid deposition n1=en:muscle weakness begins proximally | n2=en:muscle biopsy shows lipid deposition | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:muscle biopsy shows loss of myofibrillar organization n1=en:muscle weakness begins proximally | n2=en:muscle biopsy shows loss of myofibrillar organization | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:muscle biopsy shows loss of type 2a fibers n1=en:muscle weakness begins proximally | n2=en:muscle biopsy shows loss of type 2a fibers | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:muscle biopsy shows merosin (156225)-positive muscle fibers n1=en:muscle weakness begins proximally | n2=en:muscle biopsy shows merosin (156225)-positive muscle fibers | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:muscle biopsy shows mild dystrophic changes n1=en:muscle weakness begins proximally | n2=en:muscle biopsy shows mild dystrophic changes | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:muscle biopsy shows mitochondrial paracrystalline inclusions n1=en:muscle weakness begins proximally | n2=en:muscle biopsy shows mitochondrial paracrystalline inclusions | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:muscle biopsy shows myodegenerative changes with beta-amyloid and phosphorylated tau deposits n1=en:muscle weakness begins proximally | n2=en:muscle biopsy shows myodegenerative changes with beta-amyloid and phosphorylated tau deposits | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:muscle biopsy shows myofiber degeneration n1=en:muscle weakness begins proximally | n2=en:muscle biopsy shows myofiber degeneration | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:muscle biopsy shows myofibrillar changes n1=en:muscle weakness begins proximally | n2=en:muscle biopsy shows myofibrillar changes | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:muscle biopsy shows myofibrillar disruption n1=en:muscle weakness begins proximally | n2=en:muscle biopsy shows myofibrillar disruption | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:muscle biopsy shows myofibrillar myopathy n1=en:muscle weakness begins proximally | n2=en:muscle biopsy shows myofibrillar myopathy | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:muscle biopsy shows myopathic changes n1=en:muscle weakness begins proximally | n2=en:muscle biopsy shows myopathic changes | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:muscle biopsy shows myopathic or dystrophic changes n1=en:muscle weakness begins proximally | n2=en:muscle biopsy shows myopathic or dystrophic changes | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:muscle biopsy shows necrotic and atrophic fibers with centralized nuclei n1=en:muscle weakness begins proximally | n2=en:muscle biopsy shows necrotic and atrophic fibers with centralized nuclei | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:muscle biopsy shows necrotic and regenerating fibers n1=en:muscle weakness begins proximally | n2=en:muscle biopsy shows necrotic and regenerating fibers | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:muscle biopsy shows neurogenic atrophy n1=en:muscle weakness begins proximally | n2=en:muscle biopsy shows neurogenic atrophy | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:muscle biopsy shows neurogenic atrophy (1 patient) n1=en:muscle weakness begins proximally | n2=en:muscle biopsy shows neurogenic atrophy (1 patient) | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:muscle biopsy shows no dystrophic changes n1=en:muscle weakness begins proximally | n2=en:muscle biopsy shows no dystrophic changes | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:muscle biopsy shows nonspecific myopathic changes n1=en:muscle weakness begins proximally | n2=en:muscle biopsy shows nonspecific myopathic changes | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:muscle biopsy shows nonspecific myopathic changes without dystrophic or inflammatory changes n1=en:muscle weakness begins proximally | n2=en:muscle biopsy shows nonspecific myopathic changes without dystrophic or inflammatory changes | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:muscle biopsy shows ragged red fibers n1=en:muscle weakness begins proximally | n2=en:muscle biopsy shows ragged red fibers | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:muscle biopsy shows rimmed vacuoles n1=en:muscle weakness begins proximally | n2=en:muscle biopsy shows rimmed vacuoles | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:muscle biopsy shows small fibers with central nuclei and accumulation of mitochondria in the central part of the fibers n1=en:muscle weakness begins proximally | n2=en:muscle biopsy shows small fibers with central nuclei and accumulation of mitochondria in the central part of the fibers | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:muscle biopsy shows small rounded fibers n1=en:muscle weakness begins proximally | n2=en:muscle biopsy shows small rounded fibers | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:muscle biopsy shows small, membrane-bound vacuoles predominantly in type 2 fibers n1=en:muscle weakness begins proximally | n2=en:muscle biopsy shows small, membrane-bound vacuoles predominantly in type 2 fibers | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:muscle biopsy shows type 1 fiber predominance n1=en:muscle weakness begins proximally | n2=en:muscle biopsy shows type 1 fiber predominance | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:muscle biopsy shows type 1 fiber predominance and hypertrophy n1=en:muscle weakness begins proximally | n2=en:muscle biopsy shows type 1 fiber predominance and hypertrophy | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:muscle biopsy shows type 2 fiber atrophy n1=en:muscle weakness begins proximally | n2=en:muscle biopsy shows type 2 fiber atrophy | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:muscle biopsy shows variation in fiber size n1=en:muscle weakness begins proximally | n2=en:muscle biopsy shows variation in fiber size | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:muscle cramps (also seen in some heterozygotes) n1=en:muscle weakness begins proximally | n2=en:muscle cramps (also seen in some heterozygotes) | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:muscle cramps affect the upper and lower limbs n1=en:muscle weakness begins proximally | n2=en:muscle cramps affect the upper and lower limbs | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:muscle cramps during exercise n1=en:muscle weakness begins proximally | n2=en:muscle cramps during exercise | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:muscle cramps may affect jaw muscles n1=en:muscle weakness begins proximally | n2=en:muscle cramps may affect jaw muscles | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:muscle cramps, painful, recurrent n1=en:muscle weakness begins proximally | n2=en:muscle cramps, painful, recurrent | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:muscle fiber atrophy, profound (rare) n1=en:muscle weakness begins proximally | n2=en:muscle fiber atrophy, profound (rare) | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:muscle fiber necrosis n1=en:muscle weakness begins proximally | n2=en:muscle fiber necrosis | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:muscle fiber regeneration n1=en:muscle weakness begins proximally | n2=en:muscle fiber regeneration | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:muscle fiber splitting n1=en:muscle weakness begins proximally | n2=en:muscle fiber splitting | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:muscle fiber splitting and fibrosis seen on muscle biopsy n1=en:muscle weakness begins proximally | n2=en:muscle fiber splitting and fibrosis seen on muscle biopsy | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:muscle fibers appear as fetal myotubules n1=en:muscle weakness begins proximally | n2=en:muscle fibers appear as fetal myotubules | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:muscle fibers are immunoreactive for desmin and vimentin n1=en:muscle weakness begins proximally | n2=en:muscle fibers are immunoreactive for desmin and vimentin | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:muscle fibers may contain abnormal polysaccharide n1=en:muscle weakness begins proximally | n2=en:muscle fibers may contain abnormal polysaccharide | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:muscle hyperirritability n1=en:muscle weakness begins proximally | n2=en:muscle hyperirritability | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:muscle hypertrophy of the lower extremities n1=en:muscle weakness begins proximally | n2=en:muscle hypertrophy of the lower extremities | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:muscle mitochondria normal by histochemical analysis n1=en:muscle weakness begins proximally | n2=en:muscle mitochondria normal by histochemical analysis | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:muscle mounding n1=en:muscle weakness begins proximally | n2=en:muscle mounding | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:muscle pain (less common) n1=en:muscle weakness begins proximally | n2=en:muscle pain (less common) | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:muscle pain and cramps following exercise n1=en:muscle weakness begins proximally | n2=en:muscle pain and cramps following exercise | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:muscle pain with exercise (in older patients) n1=en:muscle weakness begins proximally | n2=en:muscle pain with exercise (in older patients) | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:muscle shows lipid accumulation n1=en:muscle weakness begins proximally | n2=en:muscle shows lipid accumulation | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:muscle stiffness (in older patients) n1=en:muscle weakness begins proximally | n2=en:muscle stiffness (in older patients) | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:muscle stiffness or aching n1=en:muscle weakness begins proximally | n2=en:muscle stiffness or aching | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:muscle wasting due to chronic denervation n1=en:muscle weakness begins proximally | n2=en:muscle wasting due to chronic denervation | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:muscle wasting in lower limbs n1=en:muscle weakness begins proximally | n2=en:muscle wasting in lower limbs | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:muscle weakness (hcs) n1=en:muscle weakness begins proximally | n2=en:muscle weakness (hcs) | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:muscle weakness (in some patients) n1=en:muscle weakness begins proximally | n2=en:muscle weakness (in some patients) | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:muscle weakness after cooling or on warming affected muscle n1=en:muscle weakness begins proximally | n2=en:muscle weakness after cooling or on warming affected muscle | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:muscle weakness and atrophy may be asymmetric n1=en:muscle weakness begins proximally | n2=en:muscle weakness and atrophy may be asymmetric | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:muscle weakness and atrophy, proximal n1=en:muscle weakness begins proximally | n2=en:muscle weakness and atrophy, proximal | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:muscle weakness associated with fasting or infection n1=en:muscle weakness begins proximally | n2=en:muscle weakness associated with fasting or infection | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:muscle weakness in forearm muscles n1=en:muscle weakness begins proximally | n2=en:muscle weakness in forearm muscles | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:muscle weakness is not a feature n1=en:muscle weakness begins proximally | n2=en:muscle weakness is not a feature | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:muscle weakness is predominantly of extremities and tongue n1=en:muscle weakness begins proximally | n2=en:muscle weakness is predominantly of extremities and tongue | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:muscle weakness of the face and neck, mild to moderate n1=en:muscle weakness begins proximally | n2=en:muscle weakness of the face and neck, mild to moderate | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:muscle weakness restricted to the upper limb n1=en:muscle weakness begins proximally | n2=en:muscle weakness restricted to the upper limb | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:muscle weakness usually does not occur n1=en:muscle weakness begins proximally | n2=en:muscle weakness usually does not occur | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:muscle weakness, congenital n1=en:muscle weakness begins proximally | n2=en:muscle weakness, congenital | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:muscle weakness, distal, particularly affecting the hands n1=en:muscle weakness begins proximally | n2=en:muscle weakness, distal, particularly affecting the hands | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:muscle weakness, lower limbs (patient a) n1=en:muscle weakness begins proximally | n2=en:muscle weakness, lower limbs (patient a) | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:muscle weakness, lower limbs, during exercise n1=en:muscle weakness begins proximally | n2=en:muscle weakness, lower limbs, during exercise | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:muscle weakness, mild, proximal and distal n1=en:muscle weakness begins proximally | n2=en:muscle weakness, mild, proximal and distal | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:muscle weakness, particularly of the lower limbs n1=en:muscle weakness begins proximally | n2=en:muscle weakness, particularly of the lower limbs | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:muscle weakness, predominantly proximal n1=en:muscle weakness begins proximally | n2=en:muscle weakness, predominantly proximal | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:muscle weakness, proximal and distal n1=en:muscle weakness begins proximally | n2=en:muscle weakness, proximal and distal | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:muscle weakness, proximal greater than distal n1=en:muscle weakness begins proximally | n2=en:muscle weakness, proximal greater than distal | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:muscle weakness, proximal limb muscle, mild to moderate n1=en:muscle weakness begins proximally | n2=en:muscle weakness, proximal limb muscle, mild to moderate | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:muscle weakness, proximal, limb-girdle n1=en:muscle weakness begins proximally | n2=en:muscle weakness, proximal, limb-girdle | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:muscle weakness, proximal, slowly progressive n1=en:muscle weakness begins proximally | n2=en:muscle weakness, proximal, slowly progressive | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:muscle weakness, severe, diffuse n1=en:muscle weakness begins proximally | n2=en:muscle weakness, severe, diffuse | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:muscle weakness, upper and lower limbs n1=en:muscle weakness begins proximally | n2=en:muscle weakness, upper and lower limbs | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:muscles become hard and tender during exercise n1=en:muscle weakness begins proximally | n2=en:muscles become hard and tender during exercise | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:muscles do not contract upon electrical stimulation n1=en:muscle weakness begins proximally | n2=en:muscles do not contract upon electrical stimulation | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:muscles have a woody consistency on palpation n1=en:muscle weakness begins proximally | n2=en:muscles have a woody consistency on palpation | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:muscular appearance n1=en:muscle weakness begins proximally | n2=en:muscular appearance | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:muscular dystrophy (in 1 of 3 patients) n1=en:muscle weakness begins proximally | n2=en:muscular dystrophy (in 1 of 3 patients) | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:myalgia (in some patients) n1=en:muscle weakness begins proximally | n2=en:myalgia (in some patients) | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:myalgia, episodic n1=en:muscle weakness begins proximally | n2=en:myalgia, episodic | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:myofibril destruction (in some patients) n1=en:muscle weakness begins proximally | n2=en:myofibril destruction (in some patients) | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:myofibrillar disintegration n1=en:muscle weakness begins proximally | n2=en:myofibrillar disintegration | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:myofibrillar disorganization n1=en:muscle weakness begins proximally | n2=en:myofibrillar disorganization | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:myofibrillar lesions n1=en:muscle weakness begins proximally | n2=en:myofibrillar lesions | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:myopathic changes on pathology n1=en:muscle weakness begins proximally | n2=en:myopathic changes on pathology | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:myopathic episodes triggered by exercise, fasting, infection, cold temperatures n1=en:muscle weakness begins proximally | n2=en:myopathic episodes triggered by exercise, fasting, infection, cold temperatures | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:myopathic features seen on emg n1=en:muscle weakness begins proximally | n2=en:myopathic features seen on emg | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:myopathic findings on biopsy have been occasionally reported n1=en:muscle weakness begins proximally | n2=en:myopathic findings on biopsy have been occasionally reported | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:myopathy (rare) n1=en:muscle weakness begins proximally | n2=en:myopathy (rare) | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:myopathy in approximately 45% of patients n1=en:muscle weakness begins proximally | n2=en:myopathy in approximately 45% of patients | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:myopathy, mild to severe n1=en:muscle weakness begins proximally | n2=en:myopathy, mild to severe | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:myopathy, nonprogressive n1=en:muscle weakness begins proximally | n2=en:myopathy, nonprogressive | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:myotonia (usually occurs during rapid voluntary muscle movements after a period of rest) n1=en:muscle weakness begins proximally | n2=en:myotonia (usually occurs during rapid voluntary muscle movements after a period of rest) | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:myotonia improves with continued activity ('warm-up phenomenon') n1=en:muscle weakness begins proximally | n2=en:myotonia improves with continued activity ('warm-up phenomenon') | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:myotonia is most pronounced in the extremities n1=en:muscle weakness begins proximally | n2=en:myotonia is most pronounced in the extremities | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:myotonia is present in majority of cases n1=en:muscle weakness begins proximally | n2=en:myotonia is present in majority of cases | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:myotonia is usually not seen n1=en:muscle weakness begins proximally | n2=en:myotonia is usually not seen | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:myotonia, cold-sensitive, predominantly of face, tongue, forearm, and hand precipitated by muscle cooling or cold exposure or rest after exercise n1=en:muscle weakness begins proximally | n2=en:myotonia, cold-sensitive, predominantly of face, tongue, forearm, and hand precipitated by muscle cooling or cold exposure or rest after exercise | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:myotonia, potassium-sensitive (may be responsive to acetazolamide) n1=en:muscle weakness begins proximally | n2=en:myotonia, potassium-sensitive (may be responsive to acetazolamide) | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:myotonic discharges n1=en:muscle weakness begins proximally | n2=en:myotonic discharges | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:myxedematous appearance n1=en:muscle weakness begins proximally | n2=en:myxedematous appearance | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:nearly complete absence of mechanical adipose tissue (joints, orbits, palms, soles) n1=en:muscle weakness begins proximally | n2=en:nearly complete absence of mechanical adipose tissue (joints, orbits, palms, soles) | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:nearly complete absence of metabolically active adipose tissue (subcutaneous, intraabdominal, intrathoracic) n1=en:muscle weakness begins proximally | n2=en:nearly complete absence of metabolically active adipose tissue (subcutaneous, intraabdominal, intrathoracic) | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:neck and proximal limb muscle myopathy n1=en:muscle weakness begins proximally | n2=en:neck and proximal limb muscle myopathy | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:neck flexor weakness n1=en:muscle weakness begins proximally | n2=en:neck flexor weakness | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:necrotic and atrophic fibers with centralized nuclei seen on muscle biopsy n1=en:muscle weakness begins proximally | n2=en:necrotic and atrophic fibers with centralized nuclei seen on muscle biopsy | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:necrotic and regenerating muscle fibers n1=en:muscle weakness begins proximally | n2=en:necrotic and regenerating muscle fibers | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:necrotic fibers n1=en:muscle weakness begins proximally | n2=en:necrotic fibers | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:nemaline bodies are rarely intranuclear n1=en:muscle weakness begins proximally | n2=en:nemaline bodies are rarely intranuclear | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:nemaline bodies are usually subsarcolemmal or sarcoplasmic n1=en:muscle weakness begins proximally | n2=en:nemaline bodies are usually subsarcolemmal or sarcoplasmic | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:nemaline bodies occur in type 1 fibers n1=en:muscle weakness begins proximally | n2=en:nemaline bodies occur in type 1 fibers | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:nemaline rod formation n1=en:muscle weakness begins proximally | n2=en:nemaline rod formation | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:neonatal edema (in some patients) n1=en:muscle weakness begins proximally | n2=en:neonatal edema (in some patients) | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:neurogenic atrophy n1=en:muscle weakness begins proximally | n2=en:neurogenic atrophy | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:neurogenic atrophy of muscle fibers seen on biopsy (in some patients) n1=en:muscle weakness begins proximally | n2=en:neurogenic atrophy of muscle fibers seen on biopsy (in some patients) | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:neurogenic atrophy seen on muscle biopsy n1=en:muscle weakness begins proximally | n2=en:neurogenic atrophy seen on muscle biopsy | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:no dystrophic changes n1=en:muscle weakness begins proximally | n2=en:no dystrophic changes | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:no facial muscle involvement n1=en:muscle weakness begins proximally | n2=en:no facial muscle involvement | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:no lipodystrophy in face and neck n1=en:muscle weakness begins proximally | n2=en:no lipodystrophy in face and neck | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:no muscle fiber necrosis n1=en:muscle weakness begins proximally | n2=en:no muscle fiber necrosis | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:no muscle weakness n1=en:muscle weakness begins proximally | n2=en:no muscle weakness | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:no ragged-red fibers n1=en:muscle weakness begins proximally | n2=en:no ragged-red fibers | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:no rods n1=en:muscle weakness begins proximally | n2=en:no rods | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:no staining for oxidative enzymes n1=en:muscle weakness begins proximally | n2=en:no staining for oxidative enzymes | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:non-pitting edema n1=en:muscle weakness begins proximally | n2=en:non-pitting edema | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:nonspecific muscle fiber atrophy n1=en:muscle weakness begins proximally | n2=en:nonspecific muscle fiber atrophy | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:nonspecific myopathy n1=en:muscle weakness begins proximally | n2=en:nonspecific myopathy | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:nonspecific myopathy seen on biopsy n1=en:muscle weakness begins proximally | n2=en:nonspecific myopathy seen on biopsy | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:normal dystrophin immunostaining n1=en:muscle weakness begins proximally | n2=en:normal dystrophin immunostaining | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:normal mitochondrial morphology (1 patient) n1=en:muscle weakness begins proximally | n2=en:normal mitochondrial morphology (1 patient) | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:normal neonatal period may occur before weakness is apparent n1=en:muscle weakness begins proximally | n2=en:normal neonatal period may occur before weakness is apparent | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:normal or decreased facial and neck adipose tissue n1=en:muscle weakness begins proximally | n2=en:normal or decreased facial and neck adipose tissue | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:normal or increased abdominal adipose tissue n1=en:muscle weakness begins proximally | n2=en:normal or increased abdominal adipose tissue | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:normal or increased adipose tissue around the neck n1=en:muscle weakness begins proximally | n2=en:normal or increased adipose tissue around the neck | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:normal or increased facial and neck adipose tissue n1=en:muscle weakness begins proximally | n2=en:normal or increased facial and neck adipose tissue | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:normal or increased truncal adipose tissue n1=en:muscle weakness begins proximally | n2=en:normal or increased truncal adipose tissue | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:nuclear clumps n1=en:muscle weakness begins proximally | n2=en:nuclear clumps | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:onset of lymphedema around puberty n1=en:muscle weakness begins proximally | n2=en:onset of lymphedema around puberty | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:onset of weakness in hands and feet n1=en:muscle weakness begins proximally | n2=en:onset of weakness in hands and feet | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:other mitochondrial complex enzyme activities may also be decreased n1=en:muscle weakness begins proximally | n2=en:other mitochondrial complex enzyme activities may also be decreased | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:pain or cramping during sustained manual activity n1=en:muscle weakness begins proximally | n2=en:pain or cramping during sustained manual activity | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:painful muscle cramps n1=en:muscle weakness begins proximally | n2=en:painful muscle cramps | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:painful swelling in fasciae n1=en:muscle weakness begins proximally | n2=en:painful swelling in fasciae | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:paradoxical myotonia (myotonia increases with exercise) n1=en:muscle weakness begins proximally | n2=en:paradoxical myotonia (myotonia increases with exercise) | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:paralysis of the lower limbs (later) n1=en:muscle weakness begins proximally | n2=en:paralysis of the lower limbs (later) | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:partial lipodystrophy (abnormal distribution of adipose tissue) n1=en:muscle weakness begins proximally | n2=en:partial lipodystrophy (abnormal distribution of adipose tissue) | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:partial lipodystrophy (abnormal distribution of subcutaneous adipose tissue) n1=en:muscle weakness begins proximally | n2=en:partial lipodystrophy (abnormal distribution of subcutaneous adipose tissue) | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:patchy muscle fiber degeneration n1=en:muscle weakness begins proximally | n2=en:patchy muscle fiber degeneration | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:patients achieve independent ambulation, but may lose it n1=en:muscle weakness begins proximally | n2=en:patients achieve independent ambulation, but may lose it | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:patients may have distal or proximal muscle weakness, or both n1=en:muscle weakness begins proximally | n2=en:patients may have distal or proximal muscle weakness, or both | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:pectoralis hypoplasia n1=en:muscle weakness begins proximally | n2=en:pectoralis hypoplasia | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:pectoralis major hypoplasia n1=en:muscle weakness begins proximally | n2=en:pectoralis major hypoplasia | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:pectoralis muscles may be less involved, leading to inward shrugging posture n1=en:muscle weakness begins proximally | n2=en:pectoralis muscles may be less involved, leading to inward shrugging posture | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:pelvic girdle muscle weakness (occurs earlier) n1=en:muscle weakness begins proximally | n2=en:pelvic girdle muscle weakness (occurs earlier) | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:pelvic girdle weakness and atrophy n1=en:muscle weakness begins proximally | n2=en:pelvic girdle weakness and atrophy | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:pelvic muscle involvement occurs later n1=en:muscle weakness begins proximally | n2=en:pelvic muscle involvement occurs later | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:percussion-induced muscle mounding (muscle rippling) n1=en:muscle weakness begins proximally | n2=en:percussion-induced muscle mounding (muscle rippling) | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:peroneal muscle atrophy n1=en:muscle weakness begins proximally | n2=en:peroneal muscle atrophy | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:phagocytic vacuoles with degraded membranous material n1=en:muscle weakness begins proximally | n2=en:phagocytic vacuoles with degraded membranous material | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:plaques immunoreactive for desmin and alpha-beta-crystallin n1=en:muscle weakness begins proximally | n2=en:plaques immunoreactive for desmin and alpha-beta-crystallin | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:plasma membrane discontinuities n1=en:muscle weakness begins proximally | n2=en:plasma membrane discontinuities | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:poor exercise tolerance n1=en:muscle weakness begins proximally | n2=en:poor exercise tolerance | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:poor head control in infancy n1=en:muscle weakness begins proximally | n2=en:poor head control in infancy | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:poor muscle build n1=en:muscle weakness begins proximally | n2=en:poor muscle build | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:poor muscle bulk n1=en:muscle weakness begins proximally | n2=en:poor muscle bulk | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:poor musculature n1=en:muscle weakness begins proximally | n2=en:poor musculature | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:positive staining for slow myosin heavy chain n1=en:muscle weakness begins proximally | n2=en:positive staining for slow myosin heavy chain | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:potassium sensitivity has been reported n1=en:muscle weakness begins proximally | n2=en:potassium sensitivity has been reported | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:premature exertional muscle weakness n1=en:muscle weakness begins proximally | n2=en:premature exertional muscle weakness | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:preserved junctional folds n1=en:muscle weakness begins proximally | n2=en:preserved junctional folds | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:preserved junctional structure seen on muscle biopsy n1=en:muscle weakness begins proximally | n2=en:preserved junctional structure seen on muscle biopsy | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:primarily affects lower limbs n1=en:muscle weakness begins proximally | n2=en:primarily affects lower limbs | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:progression to proximal muscle weakness n1=en:muscle weakness begins proximally | n2=en:progression to proximal muscle weakness | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:progression to wheelchair in fourth decade n1=en:muscle weakness begins proximally | n2=en:progression to wheelchair in fourth decade | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:progressive distal and proximal symmetric limb weakness n1=en:muscle weakness begins proximally | n2=en:progressive distal and proximal symmetric limb weakness | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:progressive distal muscle weakness n1=en:muscle weakness begins proximally | n2=en:progressive distal muscle weakness | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:progressive ectopic ossification (neck, dorsal trunk, proximal limbs, sternocleidomastoid, masseters) n1=en:muscle weakness begins proximally | n2=en:progressive ectopic ossification (neck, dorsal trunk, proximal limbs, sternocleidomastoid, masseters) | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:progressive interictal weakness is common n1=en:muscle weakness begins proximally | n2=en:progressive interictal weakness is common | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:progressive loss of facial adipose tissue n1=en:muscle weakness begins proximally | n2=en:progressive loss of facial adipose tissue | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:progressive proximal muscle weakness n1=en:muscle weakness begins proximally | n2=en:progressive proximal muscle weakness | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:proliferation of fatty tissue in muscle (in some patients) n1=en:muscle weakness begins proximally | n2=en:proliferation of fatty tissue in muscle (in some patients) | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:prolonged endplate potentials n1=en:muscle weakness begins proximally | n2=en:prolonged endplate potentials | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:prominent involvement of the biceps brachii muscles n1=en:muscle weakness begins proximally | n2=en:prominent involvement of the biceps brachii muscles | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:prominent involvement of the quadriceps femoris muscles n1=en:muscle weakness begins proximally | n2=en:prominent involvement of the quadriceps femoris muscles | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:prominent muscular appearance n1=en:muscle weakness begins proximally | n2=en:prominent muscular appearance | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:prominent musculature n1=en:muscle weakness begins proximally | n2=en:prominent musculature | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:proximal and distal muscle atrophy n1=en:muscle weakness begins proximally | n2=en:proximal and distal muscle atrophy | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:proximal and distal muscle atrophy in lower limbs n1=en:muscle weakness begins proximally | n2=en:proximal and distal muscle atrophy in lower limbs | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:proximal limb muscle weakness (occurs later) n1=en:muscle weakness begins proximally | n2=en:proximal limb muscle weakness (occurs later) | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:proximal limb muscle weakness initially n1=en:muscle weakness begins proximally | n2=en:proximal limb muscle weakness initially | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:proximal lower limb amyotrophy n1=en:muscle weakness begins proximally | n2=en:proximal lower limb amyotrophy | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:proximal lower limb muscle weakness, upper and lower (later onset) n1=en:muscle weakness begins proximally | n2=en:proximal lower limb muscle weakness, upper and lower (later onset) | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:proximal muscle weakness (85% of patients) n1=en:muscle weakness begins proximally | n2=en:proximal muscle weakness (85% of patients) | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:proximal muscle weakness (occasional) n1=en:muscle weakness begins proximally | n2=en:proximal muscle weakness (occasional) | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:proximal muscle weakness in upper limbs n1=en:muscle weakness begins proximally | n2=en:proximal muscle weakness in upper limbs | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:proximal muscle weakness more severe than distal muscle weakness n1=en:muscle weakness begins proximally | n2=en:proximal muscle weakness more severe than distal muscle weakness | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:proximal muscle weakness occurs later n1=en:muscle weakness begins proximally | n2=en:proximal muscle weakness occurs later | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:proximal muscle weakness, mild n1=en:muscle weakness begins proximally | n2=en:proximal muscle weakness, mild | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:proximal muscle weakness, upper and lower limbs, due to peripheral neuropathy, later in disease course n1=en:muscle weakness begins proximally | n2=en:proximal muscle weakness, upper and lower limbs, due to peripheral neuropathy, later in disease course | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:proximal upper limb amyotrophy n1=en:muscle weakness begins proximally | n2=en:proximal upper limb amyotrophy | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:proximal weakness n1=en:muscle weakness begins proximally | n2=en:proximal weakness | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:proximal weakness of the lower limbs with longer disease duration n1=en:muscle weakness begins proximally | n2=en:proximal weakness of the lower limbs with longer disease duration | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:pseudoathletic appearance with prominent muscles before disease onset n1=en:muscle weakness begins proximally | n2=en:pseudoathletic appearance with prominent muscles before disease onset | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:pyruvate oxidation defect n1=en:muscle weakness begins proximally | n2=en:pyruvate oxidation defect | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:quadriceps atrophy n1=en:muscle weakness begins proximally | n2=en:quadriceps atrophy | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:quadriceps atrophy (later onset) n1=en:muscle weakness begins proximally | n2=en:quadriceps atrophy (later onset) | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:quadriceps muscle spared n1=en:muscle weakness begins proximally | n2=en:quadriceps muscle spared | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:ragged red fibers seen on skeletal muscle biopsy n1=en:muscle weakness begins proximally | n2=en:ragged red fibers seen on skeletal muscle biopsy | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:ragged red fibers, mainly in type i fibers seen on skeletal muscle biopsy n1=en:muscle weakness begins proximally | n2=en:ragged red fibers, mainly in type i fibers seen on skeletal muscle biopsy | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:ragged-red fibers on muscle biopsy n1=en:muscle weakness begins proximally | n2=en:ragged-red fibers on muscle biopsy | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:ragged-red fibers seen on muscle biopsy n1=en:muscle weakness begins proximally | n2=en:ragged-red fibers seen on muscle biopsy | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:ragged-red muscle fibers n1=en:muscle weakness begins proximally | n2=en:ragged-red muscle fibers | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:rectus abdominis muscle separation n1=en:muscle weakness begins proximally | n2=en:rectus abdominis muscle separation | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:rectus fascia separation n1=en:muscle weakness begins proximally | n2=en:rectus fascia separation | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:rectus medial atrophy n1=en:muscle weakness begins proximally | n2=en:rectus medial atrophy | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:red-ragged fibers (2p21del) n1=en:muscle weakness begins proximally | n2=en:red-ragged fibers (2p21del) | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:reduced ankle dorsiflexion n1=en:muscle weakness begins proximally | n2=en:reduced ankle dorsiflexion | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:reduced muscle bulk n1=en:muscle weakness begins proximally | n2=en:reduced muscle bulk | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:reduced muscle mass n1=en:muscle weakness begins proximally | n2=en:reduced muscle mass | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:reduced muscle tone n1=en:muscle weakness begins proximally | n2=en:reduced muscle tone | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:reduced postsynaptic cleft area n1=en:muscle weakness begins proximally | n2=en:reduced postsynaptic cleft area | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:repetitive action potentials in response to single nerve stimulation n1=en:muscle weakness begins proximally | n2=en:repetitive action potentials in response to single nerve stimulation | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:repetitive compound muscle action potentials (cmap) in response to single stimulus n1=en:muscle weakness begins proximally | n2=en:repetitive compound muscle action potentials (cmap) in response to single stimulus | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:repetitive response to single nerve stimulation n1=en:muscle weakness begins proximally | n2=en:repetitive response to single nerve stimulation | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:repetitive response to single nerve stimulus n1=en:muscle weakness begins proximally | n2=en:repetitive response to single nerve stimulus | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:replacement of affected muscle tissue with fatty tissue n1=en:muscle weakness begins proximally | n2=en:replacement of affected muscle tissue with fatty tissue | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:respiratory distress (congenital form) n1=en:muscle weakness begins proximally | n2=en:respiratory distress (congenital form) | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:respiratory muscles may be involved (more common in juvenile-onset) n1=en:muscle weakness begins proximally | n2=en:respiratory muscles may be involved (more common in juvenile-onset) | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:retain some mechanical adipose tissue (joints, orbits, palms, soles) n1=en:muscle weakness begins proximally | n2=en:retain some mechanical adipose tissue (joints, orbits, palms, soles) | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:retroperitoneal fibrosis (rare) n1=en:muscle weakness begins proximally | n2=en:retroperitoneal fibrosis (rare) | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:rhabdomyolysis may occur n1=en:muscle weakness begins proximally | n2=en:rhabdomyolysis may occur | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:rhabdomyolysis with exercise (in older patients) n1=en:muscle weakness begins proximally | n2=en:rhabdomyolysis with exercise (in older patients) | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:rhabdomyolysis, episodic n1=en:muscle weakness begins proximally | n2=en:rhabdomyolysis, episodic | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:rhabdomyolysis, episodic and recurrent n1=en:muscle weakness begins proximally | n2=en:rhabdomyolysis, episodic and recurrent | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:rimmed vacuoles on biopsy n1=en:muscle weakness begins proximally | n2=en:rimmed vacuoles on biopsy | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:rimmed vacuoles with basophilic granular material n1=en:muscle weakness begins proximally | n2=en:rimmed vacuoles with basophilic granular material | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:rounded, atrophic fibers (family a) n1=en:muscle weakness begins proximally | n2=en:rounded, atrophic fibers (family a) | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:sarcoplasmic inclusions n1=en:muscle weakness begins proximally | n2=en:sarcoplasmic inclusions | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:scapuloperoneal amyotrophy n1=en:muscle weakness begins proximally | n2=en:scapuloperoneal amyotrophy | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:scapuloperoneal muscular atrophy due to denervation n1=en:muscle weakness begins proximally | n2=en:scapuloperoneal muscular atrophy due to denervation | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:scattered necrotic fibers n1=en:muscle weakness begins proximally | n2=en:scattered necrotic fibers | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:secondarily decreased activities of mitochondrial respiratory enzymes (in some patients) n1=en:muscle weakness begins proximally | n2=en:secondarily decreased activities of mitochondrial respiratory enzymes (in some patients) | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:secondary loss of sarcolemmal caveolin-3 n1=en:muscle weakness begins proximally | n2=en:secondary loss of sarcolemmal caveolin-3 | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:secondary myopathic features n1=en:muscle weakness begins proximally | n2=en:secondary myopathic features | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:severe disability within 20 years of onset n1=en:muscle weakness begins proximally | n2=en:severe disability within 20 years of onset | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:severe form shows absence of spontaneous activity at birth n1=en:muscle weakness begins proximally | n2=en:severe form shows absence of spontaneous activity at birth | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:severe muscle hypotonia at birth n1=en:muscle weakness begins proximally | n2=en:severe muscle hypotonia at birth | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:shortened open channel duration n1=en:muscle weakness begins proximally | n2=en:shortened open channel duration | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:shortening of flexor profundus muscle-tendon unit n1=en:muscle weakness begins proximally | n2=en:shortening of flexor profundus muscle-tendon unit | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:shortening of various muscle-tendon groups in feet n1=en:muscle weakness begins proximally | n2=en:shortening of various muscle-tendon groups in feet | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:shoulder girdle muscle atrophy n1=en:muscle weakness begins proximally | n2=en:shoulder girdle muscle atrophy | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:shoulder muscle hypoplasia n1=en:muscle weakness begins proximally | n2=en:shoulder muscle hypoplasia | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:shoulder weakness n1=en:muscle weakness begins proximally | n2=en:shoulder weakness | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:shoulder weakness and atrophy n1=en:muscle weakness begins proximally | n2=en:shoulder weakness and atrophy | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:skeletal muscle biopsy shows dystrophic changes n1=en:muscle weakness begins proximally | n2=en:skeletal muscle biopsy shows dystrophic changes | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:skeletal muscle biopsy shows hypertrophy of type 1 and 2 muscle fibers n1=en:muscle weakness begins proximally | n2=en:skeletal muscle biopsy shows hypertrophy of type 1 and 2 muscle fibers | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:skeletal muscle biopsy shows impaired respiratory oxidation n1=en:muscle weakness begins proximally | n2=en:skeletal muscle biopsy shows impaired respiratory oxidation | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:skeletal muscle biopsy shows minor variation in fiber size n1=en:muscle weakness begins proximally | n2=en:skeletal muscle biopsy shows minor variation in fiber size | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:skeletal muscle shows decreased sarcoglycan proteins n1=en:muscle weakness begins proximally | n2=en:skeletal muscle shows decreased sarcoglycan proteins | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:skeletal muscle shows dystrophic changes n1=en:muscle weakness begins proximally | n2=en:skeletal muscle shows dystrophic changes | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:slow motor responses to sudden events (i.e., falling) n1=en:muscle weakness begins proximally | n2=en:slow motor responses to sudden events (i.e., falling) | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:slowly progressive limb-girdle myopathy n1=en:muscle weakness begins proximally | n2=en:slowly progressive limb-girdle myopathy | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:small and incompletely fused muscle fibers seen on biopsy n1=en:muscle weakness begins proximally | n2=en:small and incompletely fused muscle fibers seen on biopsy | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:small nerve terminals n1=en:muscle weakness begins proximally | n2=en:small nerve terminals | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:smooth muscle may also become involved n1=en:muscle weakness begins proximally | n2=en:smooth muscle may also become involved | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:soft fleshy palms (50%) n1=en:muscle weakness begins proximally | n2=en:soft fleshy palms (50%) | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:soft tissue or tendinous calcinosis may occur n1=en:muscle weakness begins proximally | n2=en:soft tissue or tendinous calcinosis may occur | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:soft tissue vascular malformations n1=en:muscle weakness begins proximally | n2=en:soft tissue vascular malformations | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:some patients become wheelchair-dependent n1=en:muscle weakness begins proximally | n2=en:some patients become wheelchair-dependent | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:some patients never achieve ambulation n1=en:muscle weakness begins proximally | n2=en:some patients never achieve ambulation | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:some subcutaneous adipose tissue may remain on upper arms n1=en:muscle weakness begins proximally | n2=en:some subcutaneous adipose tissue may remain on upper arms | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:sparing of anterior tibialis muscle n1=en:muscle weakness begins proximally | n2=en:sparing of anterior tibialis muscle | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:sparing of small hand and finger muscles n1=en:muscle weakness begins proximally | n2=en:sparing of small hand and finger muscles | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:sparing of the anterior tibial compartment n1=en:muscle weakness begins proximally | n2=en:sparing of the anterior tibial compartment | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:sparing of the brachioradialis muscle (gives appearance of 'oblique amyotrophy') n1=en:muscle weakness begins proximally | n2=en:sparing of the brachioradialis muscle (gives appearance of 'oblique amyotrophy') | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:subsarcolemmal accumulation of enlarged mitochondria with variably sized rectangular or elongated rhomboidal paracrystalline inclusions n1=en:muscle weakness begins proximally | n2=en:subsarcolemmal accumulation of enlarged mitochondria with variably sized rectangular or elongated rhomboidal paracrystalline inclusions | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:subsarcolemmal accumulations of abnormally shaped mitochondria (on electron microscopy) n1=en:muscle weakness begins proximally | n2=en:subsarcolemmal accumulations of abnormally shaped mitochondria (on electron microscopy) | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:subsarcolemmal accumulations of abnormally shaped mitochondria seen on electron microscopy n1=en:muscle weakness begins proximally | n2=en:subsarcolemmal accumulations of abnormally shaped mitochondria seen on electron microscopy | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:subsarcolemmal accumulations of abnormally shaped mitochondria seen with electronmicroscopy n1=en:muscle weakness begins proximally | n2=en:subsarcolemmal accumulations of abnormally shaped mitochondria seen with electronmicroscopy | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:subsarcolemmal aggregates of abnormal mitochondria with concentric lamellar membranes n1=en:muscle weakness begins proximally | n2=en:subsarcolemmal aggregates of abnormal mitochondria with concentric lamellar membranes | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:subsarcolemmal hyaline bodies in type 1 fibers only n1=en:muscle weakness begins proximally | n2=en:subsarcolemmal hyaline bodies in type 1 fibers only | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:subsarcolemmal mitochondrial accumulation n1=en:muscle weakness begins proximally | n2=en:subsarcolemmal mitochondrial accumulation | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:superficial rerouting of lymph through the skin n1=en:muscle weakness begins proximally | n2=en:superficial rerouting of lymph through the skin | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:superior rectus atrophy n1=en:muscle weakness begins proximally | n2=en:superior rectus atrophy | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:swelling of the affected areas n1=en:muscle weakness begins proximally | n2=en:swelling of the affected areas | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:swelling of the extremities, episodic n1=en:muscle weakness begins proximally | n2=en:swelling of the extremities, episodic | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:symptoms are progressive for a few years, and then become stationary n1=en:muscle weakness begins proximally | n2=en:symptoms are progressive for a few years, and then become stationary | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:symptoms may be induced by heat n1=en:muscle weakness begins proximally | n2=en:symptoms may be induced by heat | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:tenderness of lower extremities n1=en:muscle weakness begins proximally | n2=en:tenderness of lower extremities | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:tendinous and tuberous xanthoma n1=en:muscle weakness begins proximally | n2=en:tendinous and tuberous xanthoma | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:tendon tears n1=en:muscle weakness begins proximally | n2=en:tendon tears | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:tetanus-like muscle contractions n1=en:muscle weakness begins proximally | n2=en:tetanus-like muscle contractions | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:thenar amyotrophy (rare) n1=en:muscle weakness begins proximally | n2=en:thenar amyotrophy (rare) | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:thickened subcutaneous tissue n1=en:muscle weakness begins proximally | n2=en:thickened subcutaneous tissue | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:thickening of the fascial structures of the palm and fingers n1=en:muscle weakness begins proximally | n2=en:thickening of the fascial structures of the palm and fingers | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:transient muscle weakness occur in 75% of patients, particularly in the arms and hands n1=en:muscle weakness begins proximally | n2=en:transient muscle weakness occur in 75% of patients, particularly in the arms and hands | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:transient neonatal hypotonia (less common) n1=en:muscle weakness begins proximally | n2=en:transient neonatal hypotonia (less common) | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:tremor at birth, involving most skeletal muscle groups, especially jaw muscles and lower limb muscles n1=en:muscle weakness begins proximally | n2=en:tremor at birth, involving most skeletal muscle groups, especially jaw muscles and lower limb muscles | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:tremors subside over the first 2 to 3 months of life n1=en:muscle weakness begins proximally | n2=en:tremors subside over the first 2 to 3 months of life | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:triceps weakness n1=en:muscle weakness begins proximally | n2=en:triceps weakness | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:tubular aggregates in muscle fibers may occur n1=en:muscle weakness begins proximally | n2=en:tubular aggregates in muscle fibers may occur | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:tubular aggregates in type 2 skeletal muscle fibers n1=en:muscle weakness begins proximally | n2=en:tubular aggregates in type 2 skeletal muscle fibers | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:tubulofilamentous inclusions n1=en:muscle weakness begins proximally | n2=en:tubulofilamentous inclusions | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:tubulofilamentous nuclear or cytoplasmic inclusions on biopsy n1=en:muscle weakness begins proximally | n2=en:tubulofilamentous nuclear or cytoplasmic inclusions on biopsy | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:type 1 and type 2 muscle fibers with 'minicore' regions of sarcomeric disorganization, lack of oxidative activity, and absent mitochondria n1=en:muscle weakness begins proximally | n2=en:type 1 and type 2 muscle fibers with 'minicore' regions of sarcomeric disorganization, lack of oxidative activity, and absent mitochondria | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:type 1 fiber atrophy n1=en:muscle weakness begins proximally | n2=en:type 1 fiber atrophy | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:type 1 fiber predominance n1=en:muscle weakness begins proximally | n2=en:type 1 fiber predominance | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:type 1 fibers are at least 12% smaller than type 2 fibers n1=en:muscle weakness begins proximally | n2=en:type 1 fibers are at least 12% smaller than type 2 fibers | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:type 1 muscle fiber predominance n1=en:muscle weakness begins proximally | n2=en:type 1 muscle fiber predominance | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:type 1 muscle fibers with clearly demarcated central 'core' regions of sarcomeric disorganization, lack of oxidative activity, and absent mitochondria n1=en:muscle weakness begins proximally | n2=en:type 1 muscle fibers with clearly demarcated central 'core' regions of sarcomeric disorganization, lack of oxidative activity, and absent mitochondria | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:type 2 fiber hypertrophy n1=en:muscle weakness begins proximally | n2=en:type 2 fiber hypertrophy | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:type 2 muscle fiber atrophy n1=en:muscle weakness begins proximally | n2=en:type 2 muscle fiber atrophy | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:type 2 muscle fiber predominance n1=en:muscle weakness begins proximally | n2=en:type 2 muscle fiber predominance | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:upper arm and pelvic muscle weakness and atrophy (later onset) n1=en:muscle weakness begins proximally | n2=en:upper arm and pelvic muscle weakness and atrophy (later onset) | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:upper limb involvement and distal muscle involvement may occur later in disease course (often by second decade) n1=en:muscle weakness begins proximally | n2=en:upper limb involvement and distal muscle involvement may occur later in disease course (often by second decade) | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:upper limb involvement occurs later or not at all n1=en:muscle weakness begins proximally | n2=en:upper limb involvement occurs later or not at all | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:upper limb muscle hypoplasia n1=en:muscle weakness begins proximally | n2=en:upper limb muscle hypoplasia | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:upper limb weakness n1=en:muscle weakness begins proximally | n2=en:upper limb weakness | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:usually a unilateral disorder n1=en:muscle weakness begins proximally | n2=en:usually a unilateral disorder | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:usually no myopathic changes on biopsy n1=en:muscle weakness begins proximally | n2=en:usually no myopathic changes on biopsy | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:uterine muscle may be stiff during pregnancy n1=en:muscle weakness begins proximally | n2=en:uterine muscle may be stiff during pregnancy | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:vacuolar degeneration n1=en:muscle weakness begins proximally | n2=en:vacuolar degeneration | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:vacuolar membranes immunostain with sarcolemmal proteins n1=en:muscle weakness begins proximally | n2=en:vacuolar membranes immunostain with sarcolemmal proteins | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:vacuolar myopathy n1=en:muscle weakness begins proximally | n2=en:vacuolar myopathy | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:vacuolar myopathy may occur n1=en:muscle weakness begins proximally | n2=en:vacuolar myopathy may occur | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:vacuolated muscle fibers show reduplication of the basement membrane n1=en:muscle weakness begins proximally | n2=en:vacuolated muscle fibers show reduplication of the basement membrane | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:vacuoles appear to be exocytosing material at the cell surface n1=en:muscle weakness begins proximally | n2=en:vacuoles appear to be exocytosing material at the cell surface | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:vacuoles are autophagocytic n1=en:muscle weakness begins proximally | n2=en:vacuoles are autophagocytic | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:vacuoles are autophagocytic and contain granular and membranous cellular debris n1=en:muscle weakness begins proximally | n2=en:vacuoles are autophagocytic and contain granular and membranous cellular debris | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:vacuoles in the myofiber cytoplasm n1=en:muscle weakness begins proximally | n2=en:vacuoles in the myofiber cytoplasm | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:variable decreases in mitochondrial respiratory complex enzyme activities n1=en:muscle weakness begins proximally | n2=en:variable decreases in mitochondrial respiratory complex enzyme activities | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:variable fiber size n1=en:muscle weakness begins proximally | n2=en:variable fiber size | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:variation in fibrodiameter seen on muscle biopsy n1=en:muscle weakness begins proximally | n2=en:variation in fibrodiameter seen on muscle biopsy | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:variation in skeletal muscle fiber diameter n1=en:muscle weakness begins proximally | n2=en:variation in skeletal muscle fiber diameter | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:variation of fiber size and shape n1=en:muscle weakness begins proximally | n2=en:variation of fiber size and shape | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:variation of myofiber diameter n1=en:muscle weakness begins proximally | n2=en:variation of myofiber diameter | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:velopharyngeal muscle weakness n1=en:muscle weakness begins proximally | n2=en:velopharyngeal muscle weakness | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:walking may be limited n1=en:muscle weakness begins proximally | n2=en:walking may be limited | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:wasting of calf muscles (rare) n1=en:muscle weakness begins proximally | n2=en:wasting of calf muscles (rare) | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:wasting, especially temporal, neck, and facial muscles n1=en:muscle weakness begins proximally | n2=en:wasting, especially temporal, neck, and facial muscles | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:weakness and wasting of the lower limbs n1=en:muscle weakness begins proximally | n2=en:weakness and wasting of the lower limbs | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:weakness of ankle and toe extensor (dorsiflexor) muscles n1=en:muscle weakness begins proximally | n2=en:weakness of ankle and toe extensor (dorsiflexor) muscles | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:weakness of ankle plantar flexion n1=en:muscle weakness begins proximally | n2=en:weakness of ankle plantar flexion | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:weakness of anterior compartment tibial muscles n1=en:muscle weakness begins proximally | n2=en:weakness of anterior compartment tibial muscles | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:weakness of long finger extensor muscles (occurs later) n1=en:muscle weakness begins proximally | n2=en:weakness of long finger extensor muscles (occurs later) | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:weakness of neck muscles may occur later n1=en:muscle weakness begins proximally | n2=en:weakness of neck muscles may occur later | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:weakness of the muscles in the anterior compartment of the lower leg (particularly the tibialis anterior muscle) n1=en:muscle weakness begins proximally | n2=en:weakness of the muscles in the anterior compartment of the lower leg (particularly the tibialis anterior muscle) | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:weakness worsened by activity n1=en:muscle weakness begins proximally | n2=en:weakness worsened by activity | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:wheelchair dependency in 20% of patients by age 40 n1=en:muscle weakness begins proximally | n2=en:wheelchair dependency in 20% of patients by age 40 | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:widening of the synaptic cleft n1=en:muscle weakness begins proximally | n2=en:widening of the synaptic cleft | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:z-band streaming n1=en:muscle weakness begins proximally | n2=en:z-band streaming | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:z-disk degeneration n1=en:muscle weakness begins proximally | n2=en:z-disk degeneration | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:z-disk streaming n1=en:muscle weakness begins proximally | n2=en:z-disk streaming | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:z-disks with abnormal homogeneous material n1=en:muscle weakness begins proximally | n2=en:z-disks with abnormal homogeneous material | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> en:z-line streaming see on electron microscopy n1=en:muscle weakness begins proximally | n2=en:z-line streaming see on electron microscopy | rel=r_associated | relid=0 | w=20 en:muscle weakness begins proximally -- r_associated #0: 20 / 0.8 -> hypoplasie glutéale n1=en:muscle weakness begins proximally | n2=hypoplasie glutéale | rel=r_associated | relid=0 | w=20

≈ 824 relations entrantes en:abnormal mitochondria --- r_associated #0: 43 --> en:muscle weakness begins proximally n1=en:abnormal mitochondria | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=43 en:calf hypertrophy (uncommon) --- r_associated #0: 43 --> en:muscle weakness begins proximally n1=en:calf hypertrophy (uncommon) | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=43 en:degeneration of junctional folds --- r_associated #0: 43 --> en:muscle weakness begins proximally n1=en:degeneration of junctional folds | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=43 en:increased lysosomal glycogen --- r_associated #0: 43 --> en:muscle weakness begins proximally n1=en:increased lysosomal glycogen | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=43 en:muscle weakness after cooling or on warming affected muscle --- r_associated #0: 43 --> en:muscle weakness begins proximally n1=en:muscle weakness after cooling or on warming affected muscle | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=43 en:progression to proximal muscle weakness --- r_associated #0: 43 --> en:muscle weakness begins proximally n1=en:progression to proximal muscle weakness | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=43 en:reduced muscle mass --- r_associated #0: 43 --> en:muscle weakness begins proximally n1=en:reduced muscle mass | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=43 en:subsarcolemmal accumulations of abnormally shaped mitochondria (on electron microscopy) --- r_associated #0: 43 --> en:muscle weakness begins proximally n1=en:subsarcolemmal accumulations of abnormally shaped mitochondria (on electron microscopy) | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=43 en:z-line streaming see on electron microscopy --- r_associated #0: 43 --> en:muscle weakness begins proximally n1=en:z-line streaming see on electron microscopy | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=43 en:deposits immunoreactive to beta-amyloid protein --- r_associated #0: 42 --> en:muscle weakness begins proximally n1=en:deposits immunoreactive to beta-amyloid protein | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=42 en:increased length of endplate regions seen on muscle biopsy --- r_associated #0: 42 --> en:muscle weakness begins proximally n1=en:increased length of endplate regions seen on muscle biopsy | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=42 en:loss of subcutaneous adipose tissue from gluteal region --- r_associated #0: 42 --> en:muscle weakness begins proximally n1=en:loss of subcutaneous adipose tissue from gluteal region | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=42 en:loss of subcutaneous adipose tissue from upper limbs and trunk --- r_associated #0: 42 --> en:muscle weakness begins proximally n1=en:loss of subcutaneous adipose tissue from upper limbs and trunk | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=42 en:muscle atrophy, progressive --- r_associated #0: 42 --> en:muscle weakness begins proximally n1=en:muscle atrophy, progressive | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=42 en:muscle pain (less common) --- r_associated #0: 42 --> en:muscle weakness begins proximally n1=en:muscle pain (less common) | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=42 en:muscle weakness (hcs) --- r_associated #0: 42 --> en:muscle weakness begins proximally n1=en:muscle weakness (hcs) | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=42 en:nearly complete absence of mechanical adipose tissue (joints, orbits, palms, soles) --- r_associated #0: 42 --> en:muscle weakness begins proximally n1=en:nearly complete absence of mechanical adipose tissue (joints, orbits, palms, soles) | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=42 en:necrotic fibers --- r_associated #0: 42 --> en:muscle weakness begins proximally n1=en:necrotic fibers | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=42 en:normal or increased adipose tissue around the neck --- r_associated #0: 42 --> en:muscle weakness begins proximally n1=en:normal or increased adipose tissue around the neck | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=42 en:quadriceps muscle spared --- r_associated #0: 42 --> en:muscle weakness begins proximally n1=en:quadriceps muscle spared | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=42 en:upper arm and pelvic muscle weakness and atrophy (later onset) --- r_associated #0: 42 --> en:muscle weakness begins proximally n1=en:upper arm and pelvic muscle weakness and atrophy (later onset) | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=42 en:wheelchair dependency in 20% of patients by age 40 --- r_associated #0: 42 --> en:muscle weakness begins proximally n1=en:wheelchair dependency in 20% of patients by age 40 | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=42 hypoplasie glutéale --- r_associated #0: 42 --> en:muscle weakness begins proximally n1=hypoplasie glutéale | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=42 en:centralized myonuclei --- r_associated #0: 41 --> en:muscle weakness begins proximally n1=en:centralized myonuclei | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=41 en:normal mitochondrial morphology (1 patient) --- r_associated #0: 41 --> en:muscle weakness begins proximally n1=en:normal mitochondrial morphology (1 patient) | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=41 en:subsarcolemmal aggregates of abnormal mitochondria with concentric lamellar membranes --- r_associated #0: 41 --> en:muscle weakness begins proximally n1=en:subsarcolemmal aggregates of abnormal mitochondria with concentric lamellar membranes | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=41 en:endplate myopathy --- r_associated #0: 40 --> en:muscle weakness begins proximally n1=en:endplate myopathy | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=40 en:muscle biopsy shows type 1 fiber predominance --- r_associated #0: 40 --> en:muscle weakness begins proximally n1=en:muscle biopsy shows type 1 fiber predominance | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=40 en:repetitive action potentials in response to single nerve stimulation --- r_associated #0: 40 --> en:muscle weakness begins proximally n1=en:repetitive action potentials in response to single nerve stimulation | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=40 en:attacks precipitated by rest after exercise --- r_associated #0: 39 --> en:muscle weakness begins proximally n1=en:attacks precipitated by rest after exercise | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=39 en:attacks usually decrease or disappear after age 40 years --- r_associated #0: 39 --> en:muscle weakness begins proximally n1=en:attacks usually decrease or disappear after age 40 years | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=39 en:decreased cytochrome c oxidase activity --- r_associated #0: 39 --> en:muscle weakness begins proximally n1=en:decreased cytochrome c oxidase activity | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=39 en:dependent edema after excess fat has been present for several years --- r_associated #0: 39 --> en:muscle weakness begins proximally n1=en:dependent edema after excess fat has been present for several years | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=39 en:gluteal hypoplasia --- r_associated #0: 39 --> en:muscle weakness begins proximally n1=en:gluteal hypoplasia | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=39 en:muscle biopsy shows myofibrillar changes --- r_associated #0: 39 --> en:muscle weakness begins proximally n1=en:muscle biopsy shows myofibrillar changes | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=39 en:muscle biopsy shows necrotic and atrophic fibers with centralized nuclei --- r_associated #0: 39 --> en:muscle weakness begins proximally n1=en:muscle biopsy shows necrotic and atrophic fibers with centralized nuclei | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=39 en:muscle biopsy shows ragged red fibers --- r_associated #0: 39 --> en:muscle weakness begins proximally n1=en:muscle biopsy shows ragged red fibers | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=39 en:muscle biopsy shows type 2 fiber atrophy --- r_associated #0: 39 --> en:muscle weakness begins proximally n1=en:muscle biopsy shows type 2 fiber atrophy | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=39 en:muscle weakness, severe, diffuse --- r_associated #0: 39 --> en:muscle weakness begins proximally n1=en:muscle weakness, severe, diffuse | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=39 en:sparing of the brachioradialis muscle (gives appearance of 'oblique amyotrophy') --- r_associated #0: 39 --> en:muscle weakness begins proximally n1=en:sparing of the brachioradialis muscle (gives appearance of 'oblique amyotrophy') | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=39 en:tetanus-like muscle contractions --- r_associated #0: 39 --> en:muscle weakness begins proximally n1=en:tetanus-like muscle contractions | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=39 en:abnormal distribution of subcutaneous fat --- r_associated #0: 38 --> en:muscle weakness begins proximally n1=en:abnormal distribution of subcutaneous fat | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=38 en:distal limb muscle weakness occurs later --- r_associated #0: 38 --> en:muscle weakness begins proximally n1=en:distal limb muscle weakness occurs later | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=38 en:muscle biopsy shows fibrosis and increased connective tissue --- r_associated #0: 38 --> en:muscle weakness begins proximally n1=en:muscle biopsy shows fibrosis and increased connective tissue | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=38 en:muscle biopsy shows type 1 fiber predominance and hypertrophy --- r_associated #0: 38 --> en:muscle weakness begins proximally n1=en:muscle biopsy shows type 1 fiber predominance and hypertrophy | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=38 en:phagocytic vacuoles with degraded membranous material --- r_associated #0: 38 --> en:muscle weakness begins proximally n1=en:phagocytic vacuoles with degraded membranous material | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=38 en:tenderness of lower extremities --- r_associated #0: 38 --> en:muscle weakness begins proximally n1=en:tenderness of lower extremities | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=38 en:atrophic fibers --- r_associated #0: 37 --> en:muscle weakness begins proximally n1=en:atrophic fibers | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=37 en:decreased muscle mitochondrial aconitase --- r_associated #0: 37 --> en:muscle weakness begins proximally n1=en:decreased muscle mitochondrial aconitase | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=37 en:distal muscle atrophy due to neuropathy --- r_associated #0: 37 --> en:muscle weakness begins proximally n1=en:distal muscle atrophy due to neuropathy | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=37 en:muscle cramps (also seen in some heterozygotes) --- r_associated #0: 37 --> en:muscle weakness begins proximally n1=en:muscle cramps (also seen in some heterozygotes) | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=37 en:severe muscle hypotonia at birth --- r_associated #0: 37 --> en:muscle weakness begins proximally n1=en:severe muscle hypotonia at birth | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=37 en:shoulder girdle muscle atrophy --- r_associated #0: 37 --> en:muscle weakness begins proximally n1=en:shoulder girdle muscle atrophy | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=37 en:disorganization of the neuromuscular junction --- r_associated #0: 36 --> en:muscle weakness begins proximally n1=en:disorganization of the neuromuscular junction | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=36 en:distal muscle weakness occurs later --- r_associated #0: 36 --> en:muscle weakness begins proximally n1=en:distal muscle weakness occurs later | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=36 en:fiber type variation --- r_associated #0: 36 --> en:muscle weakness begins proximally n1=en:fiber type variation | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=36 en:inflammatory cells absent --- r_associated #0: 36 --> en:muscle weakness begins proximally n1=en:inflammatory cells absent | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=36 en:large lipid droplets --- r_associated #0: 36 --> en:muscle weakness begins proximally n1=en:large lipid droplets | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=36 en:lymphedema, dorsa of feet --- r_associated #0: 36 --> en:muscle weakness begins proximally n1=en:lymphedema, dorsa of feet | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=36 en:mitochondria are placed at the periphery of muscle fibers --- r_associated #0: 36 --> en:muscle weakness begins proximally n1=en:mitochondria are placed at the periphery of muscle fibers | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=36 en:muscle biopsy shows glycogen accumulation in myofibrils and lysosomes --- r_associated #0: 36 --> en:muscle weakness begins proximally n1=en:muscle biopsy shows glycogen accumulation in myofibrils and lysosomes | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=36 en:myofibrillar disorganization --- r_associated #0: 36 --> en:muscle weakness begins proximally n1=en:myofibrillar disorganization | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=36 en:myotonia improves with continued activity ('warm-up phenomenon') --- r_associated #0: 36 --> en:muscle weakness begins proximally n1=en:myotonia improves with continued activity ('warm-up phenomenon') | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=36 en:positive staining for slow myosin heavy chain --- r_associated #0: 36 --> en:muscle weakness begins proximally n1=en:positive staining for slow myosin heavy chain | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=36 en:z-disk streaming --- r_associated #0: 36 --> en:muscle weakness begins proximally n1=en:z-disk streaming | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=36 en:abdominal wall muscle weakness (later onset) --- r_associated #0: 35 --> en:muscle weakness begins proximally n1=en:abdominal wall muscle weakness (later onset) | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=35 en:abnormal irregular myofibrillar network --- r_associated #0: 35 --> en:muscle weakness begins proximally n1=en:abnormal irregular myofibrillar network | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=35 en:abnormal muscle fibers with amorphous, granular, or hyaline deposits --- r_associated #0: 35 --> en:muscle weakness begins proximally n1=en:abnormal muscle fibers with amorphous, granular, or hyaline deposits | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=35 en:abnormalities in myofibril organization --- r_associated #0: 35 --> en:muscle weakness begins proximally n1=en:abnormalities in myofibril organization | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=35 en:absence of gamma-sarcoglycan protein --- r_associated #0: 35 --> en:muscle weakness begins proximally n1=en:absence of gamma-sarcoglycan protein | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=35 en:absence of necrosis --- r_associated #0: 35 --> en:muscle weakness begins proximally n1=en:absence of necrosis | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=35 en:accelerated decay of the synaptic current --- r_associated #0: 35 --> en:muscle weakness begins proximally n1=en:accelerated decay of the synaptic current | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=35 en:acetazolamide may worsen symptoms --- r_associated #0: 35 --> en:muscle weakness begins proximally n1=en:acetazolamide may worsen symptoms | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=35 en:atrophic calf muscles --- r_associated #0: 35 --> en:muscle weakness begins proximally n1=en:atrophic calf muscles | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=35 en:atrophy of the muscles in the anterior compartment of the lower leg --- r_associated #0: 35 --> en:muscle weakness begins proximally n1=en:atrophy of the muscles in the anterior compartment of the lower leg | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=35 en:atrophy of the thenar and hypothenar muscles --- r_associated #0: 35 --> en:muscle weakness begins proximally n1=en:atrophy of the thenar and hypothenar muscles | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=35 en:cores extend along length of muscle fiber --- r_associated #0: 35 --> en:muscle weakness begins proximally n1=en:cores extend along length of muscle fiber | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=35 en:cores with lack of oxidative activity and mitochondrial depletion may also be found and extend along length of fiber --- r_associated #0: 35 --> en:muscle weakness begins proximally n1=en:cores with lack of oxidative activity and mitochondrial depletion may also be found and extend along length of fiber | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=35 en:cytoplasmic inclusion bodies (finding) --- r_associated #0: 35 --> en:muscle weakness begins proximally n1=en:cytoplasmic inclusion bodies (finding) | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=35 en:decreased ability to run --- r_associated #0: 35 --> en:muscle weakness begins proximally n1=en:decreased ability to run | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=35 en:decreased miniature endplate potential (mepp) and current (mepc) --- r_associated #0: 35 --> en:muscle weakness begins proximally n1=en:decreased miniature endplate potential (mepp) and current (mepc) | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=35 en:decreased muscle succinate dehydrogenase --- r_associated #0: 35 --> en:muscle weakness begins proximally n1=en:decreased muscle succinate dehydrogenase | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=35 en:deltoid muscle hypoplasia --- r_associated #0: 35 --> en:muscle weakness begins proximally n1=en:deltoid muscle hypoplasia | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=35 en:denuded postsynaptic regions --- r_associated #0: 35 --> en:muscle weakness begins proximally n1=en:denuded postsynaptic regions | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=35 en:distal muscle atrophy (lower limbs more affected than upper limbs) --- r_associated #0: 35 --> en:muscle weakness begins proximally n1=en:distal muscle atrophy (lower limbs more affected than upper limbs) | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=35 en:distal muscle weakness and atrophy --- r_associated #0: 35 --> en:muscle weakness begins proximally n1=en:distal muscle weakness and atrophy | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=35 en:distal upper limb amyotrophy --- r_associated #0: 35 --> en:muscle weakness begins proximally n1=en:distal upper limb amyotrophy | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=35 en:distal upper limb muscle weakness --- r_associated #0: 35 --> en:muscle weakness begins proximally n1=en:distal upper limb muscle weakness | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=35 en:dystrophic changes occur later --- r_associated #0: 35 --> en:muscle weakness begins proximally n1=en:dystrophic changes occur later | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=35 en:dystrophic changes seen on muscle biopsy --- r_associated #0: 35 --> en:muscle weakness begins proximally n1=en:dystrophic changes seen on muscle biopsy | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=35 en:edema (hands and feet) --- r_associated #0: 35 --> en:muscle weakness begins proximally n1=en:edema (hands and feet) | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=35 en:electromyographic decrements in some muscles --- r_associated #0: 35 --> en:muscle weakness begins proximally n1=en:electromyographic decrements in some muscles | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=35 en:episodic weakness may or may not occur independent of myotonia --- r_associated #0: 35 --> en:muscle weakness begins proximally n1=en:episodic weakness may or may not occur independent of myotonia | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=35 en:excess fat, symmetrically located in buttocks and lower extremities to ankles --- r_associated #0: 35 --> en:muscle weakness begins proximally n1=en:excess fat, symmetrically located in buttocks and lower extremities to ankles | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=35 en:facial muscle weakness and atrophy, progressive --- r_associated #0: 35 --> en:muscle weakness begins proximally n1=en:facial muscle weakness and atrophy, progressive | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=35 en:fibrillations in affected muscles --- r_associated #0: 35 --> en:muscle weakness begins proximally n1=en:fibrillations in affected muscles | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=35 en:flaccid weakness or paralysis, episodic attacks --- r_associated #0: 35 --> en:muscle weakness begins proximally n1=en:flaccid weakness or paralysis, episodic attacks | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=35 en:foot extensor muscle weakness (later onset) --- r_associated #0: 35 --> en:muscle weakness begins proximally n1=en:foot extensor muscle weakness (later onset) | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=35 en:generalized amyoplasia --- r_associated #0: 35 --> en:muscle weakness begins proximally n1=en:generalized amyoplasia | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=35 en:glycogen depletion in skeletal muscle --- r_associated #0: 35 --> en:muscle weakness begins proximally n1=en:glycogen depletion in skeletal muscle | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=35 en:hip abductor weakness and atrophy --- r_associated #0: 35 --> en:muscle weakness begins proximally n1=en:hip abductor weakness and atrophy | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=35 en:hip flexor weakness --- r_associated #0: 35 --> en:muscle weakness begins proximally n1=en:hip flexor weakness | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=35 en:hypertrophy of calves (in 3 of 6 patients) --- r_associated #0: 35 --> en:muscle weakness begins proximally n1=en:hypertrophy of calves (in 3 of 6 patients) | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=35 en:hypotonia (families a and b) --- r_associated #0: 35 --> en:muscle weakness begins proximally n1=en:hypotonia (families a and b) | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=35 en:hypotonia, profound --- r_associated #0: 35 --> en:muscle weakness begins proximally n1=en:hypotonia, profound | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=35 en:increased endomysial connective tissue around muscle fibers --- r_associated #0: 35 --> en:muscle weakness begins proximally n1=en:increased endomysial connective tissue around muscle fibers | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=35 en:increased fatty and connective tissue in skeletal muscle --- r_associated #0: 35 --> en:muscle weakness begins proximally n1=en:increased fatty and connective tissue in skeletal muscle | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=35 en:increased glycogen --- r_associated #0: 35 --> en:muscle weakness begins proximally n1=en:increased glycogen | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=35 en:increased lipid droplets and abnormal mitochondria --- r_associated #0: 35 --> en:muscle weakness begins proximally n1=en:increased lipid droplets and abnormal mitochondria | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=35 en:involves upper and lower proximal muscles --- r_associated #0: 35 --> en:muscle weakness begins proximally n1=en:involves upper and lower proximal muscles | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=35 en:lipoatrophy, generalized --- r_associated #0: 35 --> en:muscle weakness begins proximally n1=en:lipoatrophy, generalized | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=35 en:loss of adipose tissue occurs around puberty --- r_associated #0: 35 --> en:muscle weakness begins proximally n1=en:loss of adipose tissue occurs around puberty | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=35 en:loss of gluteal adipose tissue --- r_associated #0: 35 --> en:muscle weakness begins proximally n1=en:loss of gluteal adipose tissue | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=35 en:loss of independent ambulation around age 12 years --- r_associated #0: 35 --> en:muscle weakness begins proximally n1=en:loss of independent ambulation around age 12 years | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=35 en:loss of truncal subcutaneous adipose tissue --- r_associated #0: 35 --> en:muscle weakness begins proximally n1=en:loss of truncal subcutaneous adipose tissue | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=35 en:mildly increased mtdna --- r_associated #0: 35 --> en:muscle weakness begins proximally n1=en:mildly increased mtdna | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=35 en:muscle atrophy, limb-girdle and proximal --- r_associated #0: 35 --> en:muscle weakness begins proximally n1=en:muscle atrophy, limb-girdle and proximal | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=35 en:muscle biopsy shows decreased activity of cytochrome c oxidase --- r_associated #0: 35 --> en:muscle weakness begins proximally n1=en:muscle biopsy shows decreased activity of cytochrome c oxidase | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=35 en:muscle biopsy shows degeneration of muscle fibers, variation in fiber size, fiber splitting, rimmed vacuoles, and central myonuclei --- r_associated #0: 35 --> en:muscle weakness begins proximally n1=en:muscle biopsy shows degeneration of muscle fibers, variation in fiber size, fiber splitting, rimmed vacuoles, and central myonuclei | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=35 en:muscle biopsy shows dystrophic changes --- r_associated #0: 35 --> en:muscle weakness begins proximally n1=en:muscle biopsy shows dystrophic changes | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=35 en:muscle biopsy shows lipid deposition --- r_associated #0: 35 --> en:muscle weakness begins proximally n1=en:muscle biopsy shows lipid deposition | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=35 en:muscle biopsy shows merosin (156225)-positive muscle fibers --- r_associated #0: 35 --> en:muscle weakness begins proximally n1=en:muscle biopsy shows merosin (156225)-positive muscle fibers | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=35 en:muscle biopsy shows myofibrillar disruption --- r_associated #0: 35 --> en:muscle weakness begins proximally n1=en:muscle biopsy shows myofibrillar disruption | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=35 en:muscle fibers are immunoreactive for desmin and vimentin --- r_associated #0: 35 --> en:muscle weakness begins proximally n1=en:muscle fibers are immunoreactive for desmin and vimentin | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=35 en:muscle weakness usually does not occur --- r_associated #0: 35 --> en:muscle weakness begins proximally n1=en:muscle weakness usually does not occur | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=35 en:muscular appearance --- r_associated #0: 35 --> en:muscle weakness begins proximally n1=en:muscular appearance | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=35 en:myopathic changes on pathology --- r_associated #0: 35 --> en:muscle weakness begins proximally n1=en:myopathic changes on pathology | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=35 en:myopathic episodes triggered by exercise, fasting, infection, cold temperatures --- r_associated #0: 35 --> en:muscle weakness begins proximally n1=en:myopathic episodes triggered by exercise, fasting, infection, cold temperatures | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=35 en:myotonia (usually occurs during rapid voluntary muscle movements after a period of rest) --- r_associated #0: 35 --> en:muscle weakness begins proximally n1=en:myotonia (usually occurs during rapid voluntary muscle movements after a period of rest) | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=35 en:myotonia is most pronounced in the extremities --- r_associated #0: 35 --> en:muscle weakness begins proximally n1=en:myotonia is most pronounced in the extremities | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=35 en:myotonia, cold-sensitive, predominantly of face, tongue, forearm, and hand precipitated by muscle cooling or cold exposure or rest after exercise --- r_associated #0: 35 --> en:muscle weakness begins proximally n1=en:myotonia, cold-sensitive, predominantly of face, tongue, forearm, and hand precipitated by muscle cooling or cold exposure or rest after exercise | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=35 en:nemaline bodies are rarely intranuclear --- r_associated #0: 35 --> en:muscle weakness begins proximally n1=en:nemaline bodies are rarely intranuclear | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=35 en:no staining for oxidative enzymes --- r_associated #0: 35 --> en:muscle weakness begins proximally n1=en:no staining for oxidative enzymes | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=35 en:normal neonatal period may occur before weakness is apparent --- r_associated #0: 35 --> en:muscle weakness begins proximally n1=en:normal neonatal period may occur before weakness is apparent | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=35 en:normal or increased abdominal adipose tissue --- r_associated #0: 35 --> en:muscle weakness begins proximally n1=en:normal or increased abdominal adipose tissue | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=35 en:paralysis of the lower limbs (later) --- r_associated #0: 35 --> en:muscle weakness begins proximally n1=en:paralysis of the lower limbs (later) | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=35 en:patchy muscle fiber degeneration --- r_associated #0: 35 --> en:muscle weakness begins proximally n1=en:patchy muscle fiber degeneration | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=35 en:patients achieve independent ambulation, but may lose it --- r_associated #0: 35 --> en:muscle weakness begins proximally n1=en:patients achieve independent ambulation, but may lose it | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=35 en:plasma membrane discontinuities --- r_associated #0: 35 --> en:muscle weakness begins proximally n1=en:plasma membrane discontinuities | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=35 en:poor muscle build --- r_associated #0: 35 --> en:muscle weakness begins proximally n1=en:poor muscle build | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=35 en:proximal and distal muscle atrophy in lower limbs --- r_associated #0: 35 --> en:muscle weakness begins proximally n1=en:proximal and distal muscle atrophy in lower limbs | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=35 en:proximal lower limb muscle weakness, upper and lower (later onset) --- r_associated #0: 35 --> en:muscle weakness begins proximally n1=en:proximal lower limb muscle weakness, upper and lower (later onset) | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=35 en:proximal muscle weakness occurs later --- r_associated #0: 35 --> en:muscle weakness begins proximally n1=en:proximal muscle weakness occurs later | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=35 en:pyruvate oxidation defect --- r_associated #0: 35 --> en:muscle weakness begins proximally n1=en:pyruvate oxidation defect | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=35 en:rectus abdominis muscle separation --- r_associated #0: 35 --> en:muscle weakness begins proximally n1=en:rectus abdominis muscle separation | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=35 en:rectus medial atrophy --- r_associated #0: 35 --> en:muscle weakness begins proximally n1=en:rectus medial atrophy | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=35 en:reduced postsynaptic cleft area --- r_associated #0: 35 --> en:muscle weakness begins proximally n1=en:reduced postsynaptic cleft area | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=35 en:repetitive response to single nerve stimulus --- r_associated #0: 35 --> en:muscle weakness begins proximally n1=en:repetitive response to single nerve stimulus | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=35 en:retroperitoneal fibrosis (rare) --- r_associated #0: 35 --> en:muscle weakness begins proximally n1=en:retroperitoneal fibrosis (rare) | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=35 en:rhabdomyolysis, episodic --- r_associated #0: 35 --> en:muscle weakness begins proximally n1=en:rhabdomyolysis, episodic | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=35 en:scapuloperoneal muscular atrophy due to denervation --- r_associated #0: 35 --> en:muscle weakness begins proximally n1=en:scapuloperoneal muscular atrophy due to denervation | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=35 en:severe form shows absence of spontaneous activity at birth --- r_associated #0: 35 --> en:muscle weakness begins proximally n1=en:severe form shows absence of spontaneous activity at birth | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=35 en:skeletal muscle shows decreased sarcoglycan proteins --- r_associated #0: 35 --> en:muscle weakness begins proximally n1=en:skeletal muscle shows decreased sarcoglycan proteins | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=35 en:slowly progressive limb-girdle myopathy --- r_associated #0: 35 --> en:muscle weakness begins proximally n1=en:slowly progressive limb-girdle myopathy | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=35 en:subsarcolemmal accumulations of abnormally shaped mitochondria seen on electron microscopy --- r_associated #0: 35 --> en:muscle weakness begins proximally n1=en:subsarcolemmal accumulations of abnormally shaped mitochondria seen on electron microscopy | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=35 en:superficial rerouting of lymph through the skin --- r_associated #0: 35 --> en:muscle weakness begins proximally n1=en:superficial rerouting of lymph through the skin | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=35 en:swelling of the extremities, episodic --- r_associated #0: 35 --> en:muscle weakness begins proximally n1=en:swelling of the extremities, episodic | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=35 en:symptoms may be induced by heat --- r_associated #0: 35 --> en:muscle weakness begins proximally n1=en:symptoms may be induced by heat | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=35 en:thenar amyotrophy (rare) --- r_associated #0: 35 --> en:muscle weakness begins proximally n1=en:thenar amyotrophy (rare) | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=35 en:triceps weakness --- r_associated #0: 35 --> en:muscle weakness begins proximally n1=en:triceps weakness | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=35 en:upper limb involvement and distal muscle involvement may occur later in disease course (often by second decade) --- r_associated #0: 35 --> en:muscle weakness begins proximally n1=en:upper limb involvement and distal muscle involvement may occur later in disease course (often by second decade) | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=35 en:variable fiber size --- r_associated #0: 35 --> en:muscle weakness begins proximally n1=en:variable fiber size | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=35 en:z-disk degeneration --- r_associated #0: 35 --> en:muscle weakness begins proximally n1=en:z-disk degeneration | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=35 en:abnormal fatigue --- r_associated #0: 34 --> en:muscle weakness begins proximally n1=en:abnormal fatigue | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=34 en:absence of merosin in muscle --- r_associated #0: 34 --> en:muscle weakness begins proximally n1=en:absence of merosin in muscle | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=34 en:atrophy of the lower leg muscles --- r_associated #0: 34 --> en:muscle weakness begins proximally n1=en:atrophy of the lower leg muscles | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=34 en:attacks last 4 to 24 hours --- r_associated #0: 34 --> en:muscle weakness begins proximally n1=en:attacks last 4 to 24 hours | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=34 en:autophagic rimmed vacuoles --- r_associated #0: 34 --> en:muscle weakness begins proximally n1=en:autophagic rimmed vacuoles | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=34 en:biopsy of adipose tissue shows reduced adipocyte size --- r_associated #0: 34 --> en:muscle weakness begins proximally n1=en:biopsy of adipose tissue shows reduced adipocyte size | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=34 en:biopsy shows defects in pyruvate oxidation --- r_associated #0: 34 --> en:muscle weakness begins proximally n1=en:biopsy shows defects in pyruvate oxidation | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=34 en:calf hypertrophy (reported in 1 family) --- r_associated #0: 34 --> en:muscle weakness begins proximally n1=en:calf hypertrophy (reported in 1 family) | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=34 en:centralized nuclei may be seen --- r_associated #0: 34 --> en:muscle weakness begins proximally n1=en:centralized nuclei may be seen | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=34 en:congenital, nonprogressive myopathy --- r_associated #0: 34 --> en:muscle weakness begins proximally n1=en:congenital, nonprogressive myopathy | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=34 en:cores have abrupt borders within normal regions of the muscle fiber --- r_associated #0: 34 --> en:muscle weakness begins proximally n1=en:cores have abrupt borders within normal regions of the muscle fiber | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=34 en:decreased caveolae in muscle tissue --- r_associated #0: 34 --> en:muscle weakness begins proximally n1=en:decreased caveolae in muscle tissue | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=34 en:decreased glutamate oxidation (about 63% of normal) --- r_associated #0: 34 --> en:muscle weakness begins proximally n1=en:decreased glutamate oxidation (about 63% of normal) | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=34 en:decreased mitochondria --- r_associated #0: 34 --> en:muscle weakness begins proximally n1=en:decreased mitochondria | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=34 en:decreased muscle mass --- r_associated #0: 34 --> en:muscle weakness begins proximally n1=en:decreased muscle mass | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=34 en:decreased muscle mass (especially in lower limbs) --- r_associated #0: 34 --> en:muscle weakness begins proximally n1=en:decreased muscle mass (especially in lower limbs) | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=34 en:decreased numbers of achr seen on muscle biopsy --- r_associated #0: 34 --> en:muscle weakness begins proximally n1=en:decreased numbers of achr seen on muscle biopsy | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=34 en:decreased numbers of postsynaptic nerve terminals at the neuromuscular junction --- r_associated #0: 34 --> en:muscle weakness begins proximally n1=en:decreased numbers of postsynaptic nerve terminals at the neuromuscular junction | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=34 en:decremental cmap response to repetitive nerve stimulation --- r_associated #0: 34 --> en:muscle weakness begins proximally n1=en:decremental cmap response to repetitive nerve stimulation | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=34 en:degenerating nerve terminals --- r_associated #0: 34 --> en:muscle weakness begins proximally n1=en:degenerating nerve terminals | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=34 en:distal limb muscle weakness (less common) --- r_associated #0: 34 --> en:muscle weakness begins proximally n1=en:distal limb muscle weakness (less common) | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=34 en:distal lower limb amyotrophy --- r_associated #0: 34 --> en:muscle weakness begins proximally n1=en:distal lower limb amyotrophy | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=34 en:distal muscle weakness due to neuropathy --- r_associated #0: 34 --> en:muscle weakness begins proximally n1=en:distal muscle weakness due to neuropathy | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=34 en:distal muscle weakness may occur --- r_associated #0: 34 --> en:muscle weakness begins proximally n1=en:distal muscle weakness may occur | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=34 en:distal muscle weakness of the lower limbs secondary to peripheral neuropathy --- r_associated #0: 34 --> en:muscle weakness begins proximally n1=en:distal muscle weakness of the lower limbs secondary to peripheral neuropathy | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=34 en:dystrophic changes on biopsy --- r_associated #0: 34 --> en:muscle weakness begins proximally n1=en:dystrophic changes on biopsy | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=34 en:electron microscopy shows abnormal mitochondria with disorganized and vacuolated cristae --- r_associated #0: 34 --> en:muscle weakness begins proximally n1=en:electron microscopy shows abnormal mitochondria with disorganized and vacuolated cristae | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=34 en:endomysial fibrosis --- r_associated #0: 34 --> en:muscle weakness begins proximally n1=en:endomysial fibrosis | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=34 en:fat droplets in sarcoplasm and mitochondria seen on skeletal muscle biopsy --- r_associated #0: 34 --> en:muscle weakness begins proximally n1=en:fat droplets in sarcoplasm and mitochondria seen on skeletal muscle biopsy | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=34 en:finger and wrist extensor weakness --- r_associated #0: 34 --> en:muscle weakness begins proximally n1=en:finger and wrist extensor weakness | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=34 en:focal loss of cross striations seen on muscle biopsy --- r_associated #0: 34 --> en:muscle weakness begins proximally n1=en:focal loss of cross striations seen on muscle biopsy | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=34 en:hyporeflexia in affected muscles --- r_associated #0: 34 --> en:muscle weakness begins proximally n1=en:hyporeflexia in affected muscles | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=34 en:increased connective tissue --- r_associated #0: 34 --> en:muscle weakness begins proximally n1=en:increased connective tissue | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=34 en:increased connective tissue and fat in muscles --- r_associated #0: 34 --> en:muscle weakness begins proximally n1=en:increased connective tissue and fat in muscles | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=34 en:increased muscle glycogen content --- r_associated #0: 34 --> en:muscle weakness begins proximally n1=en:increased muscle glycogen content | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=34 en:increased variability in muscle fiber diameter --- r_associated #0: 34 --> en:muscle weakness begins proximally n1=en:increased variability in muscle fiber diameter | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=34 en:interosseus muscles involved --- r_associated #0: 34 --> en:muscle weakness begins proximally n1=en:interosseus muscles involved | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=34 en:limb muscle weakness, proximal, upper and lower --- r_associated #0: 34 --> en:muscle weakness begins proximally n1=en:limb muscle weakness, proximal, upper and lower | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=34 en:limb-girdle muscle atrophy --- r_associated #0: 34 --> en:muscle weakness begins proximally n1=en:limb-girdle muscle atrophy | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=34 en:lipid droplet accumulation --- r_associated #0: 34 --> en:muscle weakness begins proximally n1=en:lipid droplet accumulation | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=34 en:lipodystrophy (in some patients) --- r_associated #0: 34 --> en:muscle weakness begins proximally n1=en:lipodystrophy (in some patients) | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=34 en:lipodystrophy, generalized, panniculitis-induced (in some) --- r_associated #0: 34 --> en:muscle weakness begins proximally n1=en:lipodystrophy, generalized, panniculitis-induced (in some) | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=34 en:loss of subcutaneous fat, generalized --- r_associated #0: 34 --> en:muscle weakness begins proximally n1=en:loss of subcutaneous fat, generalized | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=34 en:lymphedema (primarily in lower limbs, but also arms in some patients) --- r_associated #0: 34 --> en:muscle weakness begins proximally n1=en:lymphedema (primarily in lower limbs, but also arms in some patients) | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=34 en:lymphography shows hypoplasia of lymphatic vessels --- r_associated #0: 34 --> en:muscle weakness begins proximally n1=en:lymphography shows hypoplasia of lymphatic vessels | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=34 en:mallory-like bodies --- r_associated #0: 34 --> en:muscle weakness begins proximally n1=en:mallory-like bodies | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=34 en:mild weakness of the small hand muscles --- r_associated #0: 34 --> en:muscle weakness begins proximally n1=en:mild weakness of the small hand muscles | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=34 en:muscle aches, intermittent --- r_associated #0: 34 --> en:muscle weakness begins proximally n1=en:muscle aches, intermittent | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=34 en:muscle atrophy, mild, more proximal than distal --- r_associated #0: 34 --> en:muscle weakness begins proximally n1=en:muscle atrophy, mild, more proximal than distal | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=34 en:muscle biopsy shows centralized nuclei --- r_associated #0: 34 --> en:muscle weakness begins proximally n1=en:muscle biopsy shows centralized nuclei | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=34 en:muscle biopsy shows chronic and active denervation --- r_associated #0: 34 --> en:muscle weakness begins proximally n1=en:muscle biopsy shows chronic and active denervation | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=34 en:muscle biopsy shows core-like regions devoid of oxidative activity --- r_associated #0: 34 --> en:muscle weakness begins proximally n1=en:muscle biopsy shows core-like regions devoid of oxidative activity | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=34 en:muscle biopsy shows decreased or absent dysferlin staining --- r_associated #0: 34 --> en:muscle weakness begins proximally n1=en:muscle biopsy shows decreased or absent dysferlin staining | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=34 en:muscle biopsy shows variation in fiber size --- r_associated #0: 34 --> en:muscle weakness begins proximally n1=en:muscle biopsy shows variation in fiber size | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=34 en:muscle cramps may affect jaw muscles --- r_associated #0: 34 --> en:muscle weakness begins proximally n1=en:muscle cramps may affect jaw muscles | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=34 en:muscle fibers may contain abnormal polysaccharide --- r_associated #0: 34 --> en:muscle weakness begins proximally n1=en:muscle fibers may contain abnormal polysaccharide | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=34 en:muscle pain with exercise (in older patients) --- r_associated #0: 34 --> en:muscle weakness begins proximally n1=en:muscle pain with exercise (in older patients) | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=34 en:muscle shows lipid accumulation --- r_associated #0: 34 --> en:muscle weakness begins proximally n1=en:muscle shows lipid accumulation | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=34 en:muscle weakness (in some patients) --- r_associated #0: 34 --> en:muscle weakness begins proximally n1=en:muscle weakness (in some patients) | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=34 en:muscle weakness, proximal limb muscle, mild to moderate --- r_associated #0: 34 --> en:muscle weakness begins proximally n1=en:muscle weakness, proximal limb muscle, mild to moderate | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=34 en:muscular dystrophy (in 1 of 3 patients) --- r_associated #0: 34 --> en:muscle weakness begins proximally n1=en:muscular dystrophy (in 1 of 3 patients) | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=34 en:myopathy (rare) --- r_associated #0: 34 --> en:muscle weakness begins proximally n1=en:myopathy (rare) | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=34 en:myotonia is usually not seen --- r_associated #0: 34 --> en:muscle weakness begins proximally n1=en:myotonia is usually not seen | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=34 en:nemaline rod formation --- r_associated #0: 34 --> en:muscle weakness begins proximally n1=en:nemaline rod formation | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=34 en:no facial muscle involvement --- r_associated #0: 34 --> en:muscle weakness begins proximally n1=en:no facial muscle involvement | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=34 en:nonspecific myopathy --- r_associated #0: 34 --> en:muscle weakness begins proximally n1=en:nonspecific myopathy | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=34 en:other mitochondrial complex enzyme activities may also be decreased --- r_associated #0: 34 --> en:muscle weakness begins proximally n1=en:other mitochondrial complex enzyme activities may also be decreased | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=34 en:painful swelling in fasciae --- r_associated #0: 34 --> en:muscle weakness begins proximally n1=en:painful swelling in fasciae | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=34 en:poor head control in infancy --- r_associated #0: 34 --> en:muscle weakness begins proximally n1=en:poor head control in infancy | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=34 en:preserved junctional structure seen on muscle biopsy --- r_associated #0: 34 --> en:muscle weakness begins proximally n1=en:preserved junctional structure seen on muscle biopsy | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=34 en:progressive loss of facial adipose tissue --- r_associated #0: 34 --> en:muscle weakness begins proximally n1=en:progressive loss of facial adipose tissue | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=34 en:progressive proximal muscle weakness --- r_associated #0: 34 --> en:muscle weakness begins proximally n1=en:progressive proximal muscle weakness | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=34 en:proximal muscle weakness (85% of patients) --- r_associated #0: 34 --> en:muscle weakness begins proximally n1=en:proximal muscle weakness (85% of patients) | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=34 en:quadriceps atrophy --- r_associated #0: 34 --> en:muscle weakness begins proximally n1=en:quadriceps atrophy | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=34 en:ragged red fibers, mainly in type i fibers seen on skeletal muscle biopsy --- r_associated #0: 34 --> en:muscle weakness begins proximally n1=en:ragged red fibers, mainly in type i fibers seen on skeletal muscle biopsy | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=34 en:rimmed vacuoles on biopsy --- r_associated #0: 34 --> en:muscle weakness begins proximally n1=en:rimmed vacuoles on biopsy | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=34 en:soft fleshy palms (50%) --- r_associated #0: 34 --> en:muscle weakness begins proximally n1=en:soft fleshy palms (50%) | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=34 en:type 1 fibers are at least 12% smaller than type 2 fibers --- r_associated #0: 34 --> en:muscle weakness begins proximally n1=en:type 1 fibers are at least 12% smaller than type 2 fibers | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=34 en:upper limb involvement occurs later or not at all --- r_associated #0: 34 --> en:muscle weakness begins proximally n1=en:upper limb involvement occurs later or not at all | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=34 en:vacuolar membranes immunostain with sarcolemmal proteins --- r_associated #0: 34 --> en:muscle weakness begins proximally n1=en:vacuolar membranes immunostain with sarcolemmal proteins | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=34 en:vacuolar myopathy may occur --- r_associated #0: 34 --> en:muscle weakness begins proximally n1=en:vacuolar myopathy may occur | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=34 en:weakness and wasting of the lower limbs --- r_associated #0: 34 --> en:muscle weakness begins proximally n1=en:weakness and wasting of the lower limbs | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=34 en:abdominal muscle hypoplasia --- r_associated #0: 32 --> en:muscle weakness begins proximally n1=en:abdominal muscle hypoplasia | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=32 en:abnormal fat pad, buttocks and upper thighs (in some patients) --- r_associated #0: 32 --> en:muscle weakness begins proximally n1=en:abnormal fat pad, buttocks and upper thighs (in some patients) | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=32 en:abnormal variation in fiber type seen on muscle biopsy --- r_associated #0: 32 --> en:muscle weakness begins proximally n1=en:abnormal variation in fiber type seen on muscle biopsy | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=32 en:amyotrophy, distal, upper and lower limbs --- r_associated #0: 32 --> en:muscle weakness begins proximally n1=en:amyotrophy, distal, upper and lower limbs | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=32 en:angulated atrophic fibers --- r_associated #0: 32 --> en:muscle weakness begins proximally n1=en:angulated atrophic fibers | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=32 en:atrophic muscle fiber on biopsy --- r_associated #0: 32 --> en:muscle weakness begins proximally n1=en:atrophic muscle fiber on biopsy | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=32 en:atrophy of anterior compartment tibial muscles --- r_associated #0: 32 --> en:muscle weakness begins proximally n1=en:atrophy of anterior compartment tibial muscles | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=32 en:attacks precipitated by cold temperature --- r_associated #0: 32 --> en:muscle weakness begins proximally n1=en:attacks precipitated by cold temperature | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=32 en:biceps brachii atrophy --- r_associated #0: 32 --> en:muscle weakness begins proximally n1=en:biceps brachii atrophy | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=32 en:both type 1 and type 2 fiber predominance has been reported --- r_associated #0: 32 --> en:muscle weakness begins proximally n1=en:both type 1 and type 2 fiber predominance has been reported | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=32 en:congenital absence of gluteal muscles --- r_associated #0: 32 --> en:muscle weakness begins proximally n1=en:congenital absence of gluteal muscles | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=32 en:congophilic amyloid material --- r_associated #0: 32 --> en:muscle weakness begins proximally n1=en:congophilic amyloid material | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=32 en:congophilic inclusions --- r_associated #0: 32 --> en:muscle weakness begins proximally n1=en:congophilic inclusions | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=32 en:decreased activity of multiple mitochondrial respiratory complex enzymes --- r_associated #0: 32 --> en:muscle weakness begins proximally n1=en:decreased activity of multiple mitochondrial respiratory complex enzymes | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=32 en:decreased adipose tissue around neck --- r_associated #0: 32 --> en:muscle weakness begins proximally n1=en:decreased adipose tissue around neck | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=32 en:decreased atp production --- r_associated #0: 32 --> en:muscle weakness begins proximally n1=en:decreased atp production | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=32 en:decreased muscle action potential after warming affected muscle --- r_associated #0: 32 --> en:muscle weakness begins proximally n1=en:decreased muscle action potential after warming affected muscle | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=32 en:decreased muscle bulk --- r_associated #0: 32 --> en:muscle weakness begins proximally n1=en:decreased muscle bulk | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=32 en:decreased postsynaptic length --- r_associated #0: 32 --> en:muscle weakness begins proximally n1=en:decreased postsynaptic length | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=32 en:decremental response to repetitive stimulation at neuromuscular junction --- r_associated #0: 32 --> en:muscle weakness begins proximally n1=en:decremental response to repetitive stimulation at neuromuscular junction | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=32 en:dense membranous structure surrounding nuclei on electron microscopy --- r_associated #0: 32 --> en:muscle weakness begins proximally n1=en:dense membranous structure surrounding nuclei on electron microscopy | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=32 en:difficulty running or inability to run --- r_associated #0: 32 --> en:muscle weakness begins proximally n1=en:difficulty running or inability to run | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=32 en:disarray of mitochondrial cristae seen on muscle biopsy --- r_associated #0: 32 --> en:muscle weakness begins proximally n1=en:disarray of mitochondrial cristae seen on muscle biopsy | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=32 en:distal atrophy of the legs --- r_associated #0: 32 --> en:muscle weakness begins proximally n1=en:distal atrophy of the legs | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=32 en:distal limb muscle weakness and atrophy --- r_associated #0: 32 --> en:muscle weakness begins proximally n1=en:distal limb muscle weakness and atrophy | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=32 en:distal muscle atrophy due to denervation --- r_associated #0: 32 --> en:muscle weakness begins proximally n1=en:distal muscle atrophy due to denervation | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=32 en:distal muscle weakness, affecting the lower limbs --- r_associated #0: 32 --> en:muscle weakness begins proximally n1=en:distal muscle weakness, affecting the lower limbs | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=32 en:exercise intolerance (also seen in some heterozygotes) --- r_associated #0: 32 --> en:muscle weakness begins proximally n1=en:exercise intolerance (also seen in some heterozygotes) | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=32 en:fasciculations (less common) --- r_associated #0: 32 --> en:muscle weakness begins proximally n1=en:fasciculations (less common) | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=32 en:fiber size variation seen on muscle biopsy --- r_associated #0: 32 --> en:muscle weakness begins proximally n1=en:fiber size variation seen on muscle biopsy | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=32 en:firm muscles --- r_associated #0: 32 --> en:muscle weakness begins proximally n1=en:firm muscles | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=32 en:generalized muscle weakness, proximal and distal --- r_associated #0: 32 --> en:muscle weakness begins proximally n1=en:generalized muscle weakness, proximal and distal | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=32 en:granular deposits in the sarcomeres --- r_associated #0: 32 --> en:muscle weakness begins proximally n1=en:granular deposits in the sarcomeres | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=32 en:hypoglycosylation of alpha-dystroglycan seen on muscle biopsy --- r_associated #0: 32 --> en:muscle weakness begins proximally n1=en:hypoglycosylation of alpha-dystroglycan seen on muscle biopsy | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=32 en:hypotonia (patients a and c) --- r_associated #0: 32 --> en:muscle weakness begins proximally n1=en:hypotonia (patients a and c) | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=32 en:hypotonia, neonatal, severe (hcs) --- r_associated #0: 32 --> en:muscle weakness begins proximally n1=en:hypotonia, neonatal, severe (hcs) | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=32 en:increased internal nuclei in skeletal muscle fibers --- r_associated #0: 32 --> en:muscle weakness begins proximally n1=en:increased internal nuclei in skeletal muscle fibers | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=32 en:increased numbers of type 1 fibers --- r_associated #0: 32 --> en:muscle weakness begins proximally n1=en:increased numbers of type 1 fibers | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=32 en:interfibrillar and subsarcolemmal vacuoles --- r_associated #0: 32 --> en:muscle weakness begins proximally n1=en:interfibrillar and subsarcolemmal vacuoles | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=32 en:levator palpebrae superioris atrophy --- r_associated #0: 32 --> en:muscle weakness begins proximally n1=en:levator palpebrae superioris atrophy | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=32 en:limb-girdle muscle weakness, proximal, upper greater than lower --- r_associated #0: 32 --> en:muscle weakness begins proximally n1=en:limb-girdle muscle weakness, proximal, upper greater than lower | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=32 en:lipomas or lipomatous masses (most cases) --- r_associated #0: 32 --> en:muscle weakness begins proximally n1=en:lipomas or lipomatous masses (most cases) | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=32 en:loss of subcutaneous adipose tissue in limbs --- r_associated #0: 32 --> en:muscle weakness begins proximally n1=en:loss of subcutaneous adipose tissue in limbs | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=32 en:lymphedema of the hands (in some patients) --- r_associated #0: 32 --> en:muscle weakness begins proximally n1=en:lymphedema of the hands (in some patients) | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=32 en:lymphedema, of upper and/or lower extremity (rare) --- r_associated #0: 32 --> en:muscle weakness begins proximally n1=en:lymphedema, of upper and/or lower extremity (rare) | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=32 en:lymphography shows increased number of dilated lymphatic vessels (hyperplasia) --- r_associated #0: 32 --> en:muscle weakness begins proximally n1=en:lymphography shows increased number of dilated lymphatic vessels (hyperplasia) | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=32 en:marked lack of adipose tissue --- r_associated #0: 32 --> en:muscle weakness begins proximally n1=en:marked lack of adipose tissue | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=32 en:marked loss of subcutaneous fat in the limbs, face, and sometimes chest --- r_associated #0: 32 --> en:muscle weakness begins proximally n1=en:marked loss of subcutaneous fat in the limbs, face, and sometimes chest | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=32 en:mild muscle atrophy in forearm muscles --- r_associated #0: 32 --> en:muscle weakness begins proximally n1=en:mild muscle atrophy in forearm muscles | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=32 en:minicore regions are poorly defined and do not extend through entire fiber length --- r_associated #0: 32 --> en:muscle weakness begins proximally n1=en:minicore regions are poorly defined and do not extend through entire fiber length | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=32 en:minimal subcutaneous fat --- r_associated #0: 32 --> en:muscle weakness begins proximally n1=en:minimal subcutaneous fat | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=32 en:muscle atrophy restricted to the upper limb --- r_associated #0: 32 --> en:muscle weakness begins proximally n1=en:muscle atrophy restricted to the upper limb | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=32 en:muscle atrophy, upper and lower limbs --- r_associated #0: 32 --> en:muscle weakness begins proximally n1=en:muscle atrophy, upper and lower limbs | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=32 en:muscle biopsy is immunopositive for merosin (156225) --- r_associated #0: 32 --> en:muscle weakness begins proximally n1=en:muscle biopsy is immunopositive for merosin (156225) | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=32 en:muscle biopsy shows abnormal mitochondria --- r_associated #0: 32 --> en:muscle weakness begins proximally n1=en:muscle biopsy shows abnormal mitochondria | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=32 en:muscle biopsy shows loss of type 2a fibers --- r_associated #0: 32 --> en:muscle weakness begins proximally n1=en:muscle biopsy shows loss of type 2a fibers | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=32 en:muscle biopsy shows myopathic or dystrophic changes --- r_associated #0: 32 --> en:muscle weakness begins proximally n1=en:muscle biopsy shows myopathic or dystrophic changes | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=32 en:muscle biopsy shows nonspecific myopathic changes without dystrophic or inflammatory changes --- r_associated #0: 32 --> en:muscle weakness begins proximally n1=en:muscle biopsy shows nonspecific myopathic changes without dystrophic or inflammatory changes | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=32 en:muscle cramps, painful, recurrent --- r_associated #0: 32 --> en:muscle weakness begins proximally n1=en:muscle cramps, painful, recurrent | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=32 en:muscle fiber splitting and fibrosis seen on muscle biopsy --- r_associated #0: 32 --> en:muscle weakness begins proximally n1=en:muscle fiber splitting and fibrosis seen on muscle biopsy | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=32 en:muscle mitochondria normal by histochemical analysis --- r_associated #0: 32 --> en:muscle weakness begins proximally n1=en:muscle mitochondria normal by histochemical analysis | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=32 en:muscle weakness is predominantly of extremities and tongue --- r_associated #0: 32 --> en:muscle weakness begins proximally n1=en:muscle weakness is predominantly of extremities and tongue | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=32 en:muscle weakness, congenital --- r_associated #0: 32 --> en:muscle weakness begins proximally n1=en:muscle weakness, congenital | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=32 en:muscle weakness, upper and lower limbs --- r_associated #0: 32 --> en:muscle weakness begins proximally n1=en:muscle weakness, upper and lower limbs | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=32 en:muscles have a woody consistency on palpation --- r_associated #0: 32 --> en:muscle weakness begins proximally n1=en:muscles have a woody consistency on palpation | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=32 en:myofibril destruction (in some patients) --- r_associated #0: 32 --> en:muscle weakness begins proximally n1=en:myofibril destruction (in some patients) | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=32 en:nearly complete absence of metabolically active adipose tissue (subcutaneous, intraabdominal, intrathoracic) --- r_associated #0: 32 --> en:muscle weakness begins proximally n1=en:nearly complete absence of metabolically active adipose tissue (subcutaneous, intraabdominal, intrathoracic) | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=32 en:nemaline bodies occur in type 1 fibers --- r_associated #0: 32 --> en:muscle weakness begins proximally n1=en:nemaline bodies occur in type 1 fibers | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=32 en:no muscle weakness --- r_associated #0: 32 --> en:muscle weakness begins proximally n1=en:no muscle weakness | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=32 en:non-pitting edema --- r_associated #0: 32 --> en:muscle weakness begins proximally n1=en:non-pitting edema | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=32 en:nonspecific myopathy seen on biopsy --- r_associated #0: 32 --> en:muscle weakness begins proximally n1=en:nonspecific myopathy seen on biopsy | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=32 en:pain or cramping during sustained manual activity --- r_associated #0: 32 --> en:muscle weakness begins proximally n1=en:pain or cramping during sustained manual activity | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=32 en:patients may have distal or proximal muscle weakness, or both --- r_associated #0: 32 --> en:muscle weakness begins proximally n1=en:patients may have distal or proximal muscle weakness, or both | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=32 en:pelvic girdle muscle weakness (occurs earlier) --- r_associated #0: 32 --> en:muscle weakness begins proximally n1=en:pelvic girdle muscle weakness (occurs earlier) | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=32 en:peroneal muscle atrophy --- r_associated #0: 32 --> en:muscle weakness begins proximally n1=en:peroneal muscle atrophy | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=32 en:poor musculature --- r_associated #0: 32 --> en:muscle weakness begins proximally n1=en:poor musculature | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=32 en:premature exertional muscle weakness --- r_associated #0: 32 --> en:muscle weakness begins proximally n1=en:premature exertional muscle weakness | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=32 en:proliferation of fatty tissue in muscle (in some patients) --- r_associated #0: 32 --> en:muscle weakness begins proximally n1=en:proliferation of fatty tissue in muscle (in some patients) | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=32 en:proximal limb muscle weakness initially --- r_associated #0: 32 --> en:muscle weakness begins proximally n1=en:proximal limb muscle weakness initially | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=32 en:proximal muscle weakness (occasional) --- r_associated #0: 32 --> en:muscle weakness begins proximally n1=en:proximal muscle weakness (occasional) | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=32 en:red-ragged fibers (2p21del) --- r_associated #0: 32 --> en:muscle weakness begins proximally n1=en:red-ragged fibers (2p21del) | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=32 en:respiratory muscles may be involved (more common in juvenile-onset) --- r_associated #0: 32 --> en:muscle weakness begins proximally n1=en:respiratory muscles may be involved (more common in juvenile-onset) | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=32 en:rhabdomyolysis with exercise (in older patients) --- r_associated #0: 32 --> en:muscle weakness begins proximally n1=en:rhabdomyolysis with exercise (in older patients) | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=32 en:severe disability within 20 years of onset --- r_associated #0: 32 --> en:muscle weakness begins proximally n1=en:severe disability within 20 years of onset | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=32 en:skeletal muscle biopsy shows minor variation in fiber size --- r_associated #0: 32 --> en:muscle weakness begins proximally n1=en:skeletal muscle biopsy shows minor variation in fiber size | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=32 en:symptoms are progressive for a few years, and then become stationary --- r_associated #0: 32 --> en:muscle weakness begins proximally n1=en:symptoms are progressive for a few years, and then become stationary | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=32 en:tendinous and tuberous xanthoma --- r_associated #0: 32 --> en:muscle weakness begins proximally n1=en:tendinous and tuberous xanthoma | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=32 en:tendon tears --- r_associated #0: 32 --> en:muscle weakness begins proximally n1=en:tendon tears | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=32 en:transient muscle weakness occur in 75% of patients, particularly in the arms and hands --- r_associated #0: 32 --> en:muscle weakness begins proximally n1=en:transient muscle weakness occur in 75% of patients, particularly in the arms and hands | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=32 en:tubular aggregates in muscle fibers may occur --- r_associated #0: 32 --> en:muscle weakness begins proximally n1=en:tubular aggregates in muscle fibers may occur | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=32 en:type 2 muscle fiber predominance --- r_associated #0: 32 --> en:muscle weakness begins proximally n1=en:type 2 muscle fiber predominance | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=32 en:vacuolar degeneration --- r_associated #0: 32 --> en:muscle weakness begins proximally n1=en:vacuolar degeneration | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=32 en:vacuolated muscle fibers show reduplication of the basement membrane --- r_associated #0: 32 --> en:muscle weakness begins proximally n1=en:vacuolated muscle fibers show reduplication of the basement membrane | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=32 en:weakness of long finger extensor muscles (occurs later) --- r_associated #0: 32 --> en:muscle weakness begins proximally n1=en:weakness of long finger extensor muscles (occurs later) | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=32 en:weakness of neck muscles may occur later --- r_associated #0: 32 --> en:muscle weakness begins proximally n1=en:weakness of neck muscles may occur later | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=32 en:weakness worsened by activity --- r_associated #0: 32 --> en:muscle weakness begins proximally n1=en:weakness worsened by activity | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=32 en:absence of myotonia in infancy (congenital form) --- r_associated #0: 31 --> en:muscle weakness begins proximally n1=en:absence of myotonia in infancy (congenital form) | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=31 en:absence of telethonin protein --- r_associated #0: 31 --> en:muscle weakness begins proximally n1=en:absence of telethonin protein | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=31 en:accumulation of intrasarcoplasmic granulofilamentous aggregates that are immunoreactive to desmin and alpha-beta-crystallin --- r_associated #0: 31 --> en:muscle weakness begins proximally n1=en:accumulation of intrasarcoplasmic granulofilamentous aggregates that are immunoreactive to desmin and alpha-beta-crystallin | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=31 en:acquire ability to walk and jump in childhood, but motor regression occurs later --- r_associated #0: 31 --> en:muscle weakness begins proximally n1=en:acquire ability to walk and jump in childhood, but motor regression occurs later | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=31 en:affected muscles show atrophy --- r_associated #0: 31 --> en:muscle weakness begins proximally n1=en:affected muscles show atrophy | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=31 en:biopsy shows dystrophic changes --- r_associated #0: 31 --> en:muscle weakness begins proximally n1=en:biopsy shows dystrophic changes | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=31 en:cellulitis or infection may occur --- r_associated #0: 31 --> en:muscle weakness begins proximally n1=en:cellulitis or infection may occur | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=31 en:congenital myasthenic syndrome (reported in 1 patient who survived to age 20 years) --- r_associated #0: 31 --> en:muscle weakness begins proximally n1=en:congenital myasthenic syndrome (reported in 1 patient who survived to age 20 years) | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=31 en:decreased achr --- r_associated #0: 31 --> en:muscle weakness begins proximally n1=en:decreased achr | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=31 en:decreased activities of mitochondrial-encoded respiratory chain complexes --- r_associated #0: 31 --> en:muscle weakness begins proximally n1=en:decreased activities of mitochondrial-encoded respiratory chain complexes | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=31 en:decreased activity of cytochrome c oxidase seen on muscle biopsy --- r_associated #0: 31 --> en:muscle weakness begins proximally n1=en:decreased activity of cytochrome c oxidase seen on muscle biopsy | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=31 en:decreased distal reflexes --- r_associated #0: 31 --> en:muscle weakness begins proximally n1=en:decreased distal reflexes | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=31 en:decreased exercise tolerance --- r_associated #0: 31 --> en:muscle weakness begins proximally n1=en:decreased exercise tolerance | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=31 en:decreased glycosylation of alpha-dystroglycan --- r_associated #0: 31 --> en:muscle weakness begins proximally n1=en:decreased glycosylation of alpha-dystroglycan | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=31 en:decreased muscle density on imaging --- r_associated #0: 31 --> en:muscle weakness begins proximally n1=en:decreased muscle density on imaging | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=31 en:decreased spontaneous miniature endplate potentials (mepp) --- r_associated #0: 31 --> en:muscle weakness begins proximally n1=en:decreased spontaneous miniature endplate potentials (mepp) | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=31 en:decremental cmap response to repetitive nerve stimulation seen on emg --- r_associated #0: 31 --> en:muscle weakness begins proximally n1=en:decremental cmap response to repetitive nerve stimulation seen on emg | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=31 en:difficulty walking and climbing stairs (patient a) --- r_associated #0: 31 --> en:muscle weakness begins proximally n1=en:difficulty walking and climbing stairs (patient a) | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=31 en:distal leg muscle atrophy --- r_associated #0: 31 --> en:muscle weakness begins proximally n1=en:distal leg muscle atrophy | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=31 en:distal muscle weakness (first affects anterior leg muscles, then posterior leg muscles) --- r_associated #0: 31 --> en:muscle weakness begins proximally n1=en:distal muscle weakness (first affects anterior leg muscles, then posterior leg muscles) | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=31 en:distal muscle weakness and atrophy may occur, upper and lower limbs affected --- r_associated #0: 31 --> en:muscle weakness begins proximally n1=en:distal muscle weakness and atrophy may occur, upper and lower limbs affected | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=31 en:distal muscle weakness, lower legs --- r_associated #0: 31 --> en:muscle weakness begins proximally n1=en:distal muscle weakness, lower legs | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=31 en:distal muscle weakness, mild --- r_associated #0: 31 --> en:muscle weakness begins proximally n1=en:distal muscle weakness, mild | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=31 en:electromyography shows myotonic discharges --- r_associated #0: 31 --> en:muscle weakness begins proximally n1=en:electromyography shows myotonic discharges | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=31 en:extensor muscle weakness more severe than flexor muscle weakness --- r_associated #0: 31 --> en:muscle weakness begins proximally n1=en:extensor muscle weakness more severe than flexor muscle weakness | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=31 en:generalized muscle wasting --- r_associated #0: 31 --> en:muscle weakness begins proximally n1=en:generalized muscle wasting | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=31 en:glycogenosis of skeletal muscle, mild (in some patients) --- r_associated #0: 31 --> en:muscle weakness begins proximally n1=en:glycogenosis of skeletal muscle, mild (in some patients) | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=31 en:heterotopic bone formation in subcutaneous fat --- r_associated #0: 31 --> en:muscle weakness begins proximally n1=en:heterotopic bone formation in subcutaneous fat | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=31 en:hip girdle muscle weakness (usually presenting symptom) --- r_associated #0: 31 --> en:muscle weakness begins proximally n1=en:hip girdle muscle weakness (usually presenting symptom) | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=31 en:hypertrophy of the extensor digitorum brevis muscles --- r_associated #0: 31 --> en:muscle weakness begins proximally n1=en:hypertrophy of the extensor digitorum brevis muscles | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=31 en:hypoplasia of serratus anterior muscle --- r_associated #0: 31 --> en:muscle weakness begins proximally n1=en:hypoplasia of serratus anterior muscle | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=31 en:hypoplasia of the hand muscles (29%) --- r_associated #0: 31 --> en:muscle weakness begins proximally n1=en:hypoplasia of the hand muscles (29%) | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=31 en:imaging shows muscle atrophy and fatty replacement --- r_associated #0: 31 --> en:muscle weakness begins proximally n1=en:imaging shows muscle atrophy and fatty replacement | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=31 en:increased adipose fibrosis --- r_associated #0: 31 --> en:muscle weakness begins proximally n1=en:increased adipose fibrosis | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=31 en:increased endo- and perimysial connective tissue --- r_associated #0: 31 --> en:muscle weakness begins proximally n1=en:increased endo- and perimysial connective tissue | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=31 en:increased fatigue --- r_associated #0: 31 --> en:muscle weakness begins proximally n1=en:increased fatigue | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=31 en:increased fibrosis (in some patients) --- r_associated #0: 31 --> en:muscle weakness begins proximally n1=en:increased fibrosis (in some patients) | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=31 en:increased intramuscular fat --- r_associated #0: 31 --> en:muscle weakness begins proximally n1=en:increased intramuscular fat | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=31 en:increased variation in fiber size seen on muscle biopsy --- r_associated #0: 31 --> en:muscle weakness begins proximally n1=en:increased variation in fiber size seen on muscle biopsy | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=31 en:indentations or folds of the sarcolemma are connected to the membranes enclosing the vacuoles --- r_associated #0: 31 --> en:muscle weakness begins proximally n1=en:indentations or folds of the sarcolemma are connected to the membranes enclosing the vacuoles | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=31 en:intermyofibrillar and subsarcolemmal granulofilamentous protein aggregates --- r_associated #0: 31 --> en:muscle weakness begins proximally n1=en:intermyofibrillar and subsarcolemmal granulofilamentous protein aggregates | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=31 en:internal nuclei --- r_associated #0: 31 --> en:muscle weakness begins proximally n1=en:internal nuclei | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=31 en:lymphedema of the extremities --- r_associated #0: 31 --> en:muscle weakness begins proximally n1=en:lymphedema of the extremities | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=31 en:mild weakness --- r_associated #0: 31 --> en:muscle weakness begins proximally n1=en:mild weakness | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=31 en:minicores extend full fiber diameter --- r_associated #0: 31 --> en:muscle weakness begins proximally n1=en:minicores extend full fiber diameter | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=31 en:muscle atrophy in the limbs --- r_associated #0: 31 --> en:muscle weakness begins proximally n1=en:muscle atrophy in the limbs | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=31 en:muscle atrophy, especially quadriceps and forearm muscles --- r_associated #0: 31 --> en:muscle weakness begins proximally n1=en:muscle atrophy, especially quadriceps and forearm muscles | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=31 en:muscle biopsy may show inflammatory changes --- r_associated #0: 31 --> en:muscle weakness begins proximally n1=en:muscle biopsy may show inflammatory changes | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=31 en:muscle biopsy shows abnormal fiber size and variation --- r_associated #0: 31 --> en:muscle weakness begins proximally n1=en:muscle biopsy shows abnormal fiber size and variation | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=31 en:muscle biopsy shows small rounded fibers --- r_associated #0: 31 --> en:muscle weakness begins proximally n1=en:muscle biopsy shows small rounded fibers | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=31 en:muscle fiber atrophy, profound (rare) --- r_associated #0: 31 --> en:muscle weakness begins proximally n1=en:muscle fiber atrophy, profound (rare) | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=31 en:muscle fiber splitting --- r_associated #0: 31 --> en:muscle weakness begins proximally n1=en:muscle fiber splitting | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=31 en:muscle wasting due to chronic denervation --- r_associated #0: 31 --> en:muscle weakness begins proximally n1=en:muscle wasting due to chronic denervation | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=31 en:muscle weakness, mild, proximal and distal --- r_associated #0: 31 --> en:muscle weakness begins proximally n1=en:muscle weakness, mild, proximal and distal | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=31 en:muscle weakness, proximal greater than distal --- r_associated #0: 31 --> en:muscle weakness begins proximally n1=en:muscle weakness, proximal greater than distal | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=31 en:myalgia, episodic --- r_associated #0: 31 --> en:muscle weakness begins proximally n1=en:myalgia, episodic | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=31 en:myopathic features seen on emg --- r_associated #0: 31 --> en:muscle weakness begins proximally n1=en:myopathic features seen on emg | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=31 en:myopathy, nonprogressive --- r_associated #0: 31 --> en:muscle weakness begins proximally n1=en:myopathy, nonprogressive | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=31 en:neurogenic atrophy --- r_associated #0: 31 --> en:muscle weakness begins proximally n1=en:neurogenic atrophy | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=31 en:normal or increased facial and neck adipose tissue --- r_associated #0: 31 --> en:muscle weakness begins proximally n1=en:normal or increased facial and neck adipose tissue | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=31 en:partial lipodystrophy (abnormal distribution of adipose tissue) --- r_associated #0: 31 --> en:muscle weakness begins proximally n1=en:partial lipodystrophy (abnormal distribution of adipose tissue) | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=31 en:poor muscle bulk --- r_associated #0: 31 --> en:muscle weakness begins proximally n1=en:poor muscle bulk | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=31 en:primarily affects lower limbs --- r_associated #0: 31 --> en:muscle weakness begins proximally n1=en:primarily affects lower limbs | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=31 en:proximal muscle weakness, mild --- r_associated #0: 31 --> en:muscle weakness begins proximally n1=en:proximal muscle weakness, mild | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=31 en:quadriceps atrophy (later onset) --- r_associated #0: 31 --> en:muscle weakness begins proximally n1=en:quadriceps atrophy (later onset) | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=31 en:ragged-red fibers on muscle biopsy --- r_associated #0: 31 --> en:muscle weakness begins proximally n1=en:ragged-red fibers on muscle biopsy | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=31 en:rectus fascia separation --- r_associated #0: 31 --> en:muscle weakness begins proximally n1=en:rectus fascia separation | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=31 en:reduced ankle dorsiflexion --- r_associated #0: 31 --> en:muscle weakness begins proximally n1=en:reduced ankle dorsiflexion | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=31 en:rimmed vacuoles with basophilic granular material --- r_associated #0: 31 --> en:muscle weakness begins proximally n1=en:rimmed vacuoles with basophilic granular material | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=31 en:skeletal muscle biopsy shows hypertrophy of type 1 and 2 muscle fibers --- r_associated #0: 31 --> en:muscle weakness begins proximally n1=en:skeletal muscle biopsy shows hypertrophy of type 1 and 2 muscle fibers | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=31 en:soft tissue or tendinous calcinosis may occur --- r_associated #0: 31 --> en:muscle weakness begins proximally n1=en:soft tissue or tendinous calcinosis may occur | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=31 en:some patients never achieve ambulation --- r_associated #0: 31 --> en:muscle weakness begins proximally n1=en:some patients never achieve ambulation | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=31 en:superior rectus atrophy --- r_associated #0: 31 --> en:muscle weakness begins proximally n1=en:superior rectus atrophy | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=31 en:tubular aggregates in type 2 skeletal muscle fibers --- r_associated #0: 31 --> en:muscle weakness begins proximally n1=en:tubular aggregates in type 2 skeletal muscle fibers | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=31 en:type 1 fiber atrophy --- r_associated #0: 31 --> en:muscle weakness begins proximally n1=en:type 1 fiber atrophy | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=31 en:type 1 muscle fibers with clearly demarcated central 'core' regions of sarcomeric disorganization, lack of oxidative activity, and absent mitochondria --- r_associated #0: 31 --> en:muscle weakness begins proximally n1=en:type 1 muscle fibers with clearly demarcated central 'core' regions of sarcomeric disorganization, lack of oxidative activity, and absent mitochondria | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=31 en:usually a unilateral disorder --- r_associated #0: 31 --> en:muscle weakness begins proximally n1=en:usually a unilateral disorder | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=31 en:walking may be limited --- r_associated #0: 31 --> en:muscle weakness begins proximally n1=en:walking may be limited | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=31 en:wasting of calf muscles (rare) --- r_associated #0: 31 --> en:muscle weakness begins proximally n1=en:wasting of calf muscles (rare) | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=31 en:z-band streaming --- r_associated #0: 31 --> en:muscle weakness begins proximally n1=en:z-band streaming | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=31 en:a subset of patients have aggravation on cold exposure ('cold paresis') --- r_associated #0: 30 --> en:muscle weakness begins proximally n1=en:a subset of patients have aggravation on cold exposure ('cold paresis') | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=30 en:abnormal changes in the organization of the sarcolemma and the subsarcolemmal membrane cytoskeleton --- r_associated #0: 30 --> en:muscle weakness begins proximally n1=en:abnormal changes in the organization of the sarcolemma and the subsarcolemmal membrane cytoskeleton | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=30 en:abnormal fiber size variation --- r_associated #0: 30 --> en:muscle weakness begins proximally n1=en:abnormal fiber size variation | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=30 en:absence of laminin alpha-2 chain in muscle --- r_associated #0: 30 --> en:muscle weakness begins proximally n1=en:absence of laminin alpha-2 chain in muscle | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=30 en:absence of spontaneous activity at birth (severe form) --- r_associated #0: 30 --> en:muscle weakness begins proximally n1=en:absence of spontaneous activity at birth (severe form) | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=30 en:angular fibers (in some patients) --- r_associated #0: 30 --> en:muscle weakness begins proximally n1=en:angular fibers (in some patients) | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=30 en:angulated fibers --- r_associated #0: 30 --> en:muscle weakness begins proximally n1=en:angulated fibers | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=30 en:atrophy of neck muscles may occur later --- r_associated #0: 30 --> en:muscle weakness begins proximally n1=en:atrophy of neck muscles may occur later | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=30 en:atrophy of the intrinsic foot and hand muscles --- r_associated #0: 30 --> en:muscle weakness begins proximally n1=en:atrophy of the intrinsic foot and hand muscles | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=30 en:attacks precipitated by potassium --- r_associated #0: 30 --> en:muscle weakness begins proximally n1=en:attacks precipitated by potassium | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=30 en:attacks relieved by potassium administration --- r_associated #0: 30 --> en:muscle weakness begins proximally n1=en:attacks relieved by potassium administration | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=30 en:biopsy shows rimmed vacuoles, central nuclei, and variation in fiber size --- r_associated #0: 30 --> en:muscle weakness begins proximally n1=en:biopsy shows rimmed vacuoles, central nuclei, and variation in fiber size | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=30 en:calf hypertrophy (early in the disease) --- r_associated #0: 30 --> en:muscle weakness begins proximally n1=en:calf hypertrophy (early in the disease) | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=30 en:calf hypertrophy (less common) --- r_associated #0: 30 --> en:muscle weakness begins proximally n1=en:calf hypertrophy (less common) | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=30 en:congophilic deposits --- r_associated #0: 30 --> en:muscle weakness begins proximally n1=en:congophilic deposits | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=30 en:cores or minicores --- r_associated #0: 30 --> en:muscle weakness begins proximally n1=en:cores or minicores | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=30 en:decreased lactate clearance from muscle after exercise (reported in 1 patient) --- r_associated #0: 30 --> en:muscle weakness begins proximally n1=en:decreased lactate clearance from muscle after exercise (reported in 1 patient) | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=30 en:degenerating fibers --- r_associated #0: 30 --> en:muscle weakness begins proximally n1=en:degenerating fibers | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=30 en:difficulty rising from a squatting position --- r_associated #0: 30 --> en:muscle weakness begins proximally n1=en:difficulty rising from a squatting position | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=30 en:difficulty rising from chair --- r_associated #0: 30 --> en:muscle weakness begins proximally n1=en:difficulty rising from chair | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=30 en:difficulty walking, running, climbing stairs --- r_associated #0: 30 --> en:muscle weakness begins proximally n1=en:difficulty walking, running, climbing stairs | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=30 en:distal muscle weakness, occurs initially --- r_associated #0: 30 --> en:muscle weakness begins proximally n1=en:distal muscle weakness, occurs initially | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=30 en:distal muscles may be affected --- r_associated #0: 30 --> en:muscle weakness begins proximally n1=en:distal muscles may be affected | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=30 en:dystrophic changes --- r_associated #0: 30 --> en:muscle weakness begins proximally n1=en:dystrophic changes | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=30 en:edema, subcutaneous, generalized --- r_associated #0: 30 --> en:muscle weakness begins proximally n1=en:edema, subcutaneous, generalized | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=30 en:eosinophilic inclusions --- r_associated #0: 30 --> en:muscle weakness begins proximally n1=en:eosinophilic inclusions | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=30 en:exercise-induced weakness --- r_associated #0: 30 --> en:muscle weakness begins proximally n1=en:exercise-induced weakness | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=30 en:exertional fatigue --- r_associated #0: 30 --> en:muscle weakness begins proximally n1=en:exertional fatigue | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=30 en:hamstring muscle affected --- r_associated #0: 30 --> en:muscle weakness begins proximally n1=en:hamstring muscle affected | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=30 en:hand and foot weakness --- r_associated #0: 30 --> en:muscle weakness begins proximally n1=en:hand and foot weakness | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=30 en:hypoplasia of supraspinatus muscle --- r_associated #0: 30 --> en:muscle weakness begins proximally n1=en:hypoplasia of supraspinatus muscle | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=30 en:hypotonia (45%) --- r_associated #0: 30 --> en:muscle weakness begins proximally n1=en:hypotonia (45%) | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=30 en:hypotonia, truncal and appendicular --- r_associated #0: 30 --> en:muscle weakness begins proximally n1=en:hypotonia, truncal and appendicular | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=30 en:inability to stand on tiptoes --- r_associated #0: 30 --> en:muscle weakness begins proximally n1=en:inability to stand on tiptoes | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=30 en:increased intraabdominal fat --- r_associated #0: 30 --> en:muscle weakness begins proximally n1=en:increased intraabdominal fat | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=30 en:lafora bodies (accumulation of polyglucosan) seen on skeletal muscle biopsy --- r_associated #0: 30 --> en:muscle weakness begins proximally n1=en:lafora bodies (accumulation of polyglucosan) seen on skeletal muscle biopsy | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=30 en:limb-girdle myopathy --- r_associated #0: 30 --> en:muscle weakness begins proximally n1=en:limb-girdle myopathy | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=30 en:lipid storage, mainly in type i fibers --- r_associated #0: 30 --> en:muscle weakness begins proximally n1=en:lipid storage, mainly in type i fibers | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=30 en:lipoatrophy (lower face, upper limb, buttock) --- r_associated #0: 30 --> en:muscle weakness begins proximally n1=en:lipoatrophy (lower face, upper limb, buttock) | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=30 en:loss of ambulation between third and sixth decade --- r_associated #0: 30 --> en:muscle weakness begins proximally n1=en:loss of ambulation between third and sixth decade | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=30 en:loss of subcutaneous adipose tissue primarily in gluteal region and lower limbs --- r_associated #0: 30 --> en:muscle weakness begins proximally n1=en:loss of subcutaneous adipose tissue primarily in gluteal region and lower limbs | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=30 en:mitochondrial proliferation --- r_associated #0: 30 --> en:muscle weakness begins proximally n1=en:mitochondrial proliferation | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=30 en:muscle atrophy affecting the upper back and neck muscles --- r_associated #0: 30 --> en:muscle weakness begins proximally n1=en:muscle atrophy affecting the upper back and neck muscles | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=30 en:muscle biopsy shows 60-80-nm tubular aggregates arranged in hexagonal arrays in type 2 fibers --- r_associated #0: 30 --> en:muscle weakness begins proximally n1=en:muscle biopsy shows 60-80-nm tubular aggregates arranged in hexagonal arrays in type 2 fibers | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=30 en:muscle biopsy shows dystrophic features --- r_associated #0: 30 --> en:muscle weakness begins proximally n1=en:muscle biopsy shows dystrophic features | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=30 en:muscle biopsy shows dystrophic pattern --- r_associated #0: 30 --> en:muscle weakness begins proximally n1=en:muscle biopsy shows dystrophic pattern | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=30 en:muscle biopsy shows increased subsarcolemmal vacuolar glycogen accumulation --- r_associated #0: 30 --> en:muscle weakness begins proximally n1=en:muscle biopsy shows increased subsarcolemmal vacuolar glycogen accumulation | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=30 en:muscle biopsy shows increased variation in fiber size --- r_associated #0: 30 --> en:muscle weakness begins proximally n1=en:muscle biopsy shows increased variation in fiber size | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=30 en:muscle biopsy shows myodegenerative changes with beta-amyloid and phosphorylated tau deposits --- r_associated #0: 30 --> en:muscle weakness begins proximally n1=en:muscle biopsy shows myodegenerative changes with beta-amyloid and phosphorylated tau deposits | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=30 en:muscle biopsy shows myofibrillar myopathy --- r_associated #0: 30 --> en:muscle weakness begins proximally n1=en:muscle biopsy shows myofibrillar myopathy | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=30 en:muscle biopsy shows nonspecific myopathic changes --- r_associated #0: 30 --> en:muscle weakness begins proximally n1=en:muscle biopsy shows nonspecific myopathic changes | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=30 en:muscle cramps during exercise --- r_associated #0: 30 --> en:muscle weakness begins proximally n1=en:muscle cramps during exercise | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=30 en:muscle hypertrophy of the lower extremities --- r_associated #0: 30 --> en:muscle weakness begins proximally n1=en:muscle hypertrophy of the lower extremities | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=30 en:muscle weakness, lower limbs (patient a) --- r_associated #0: 30 --> en:muscle weakness begins proximally n1=en:muscle weakness, lower limbs (patient a) | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=30 en:muscle weakness, lower limbs, during exercise --- r_associated #0: 30 --> en:muscle weakness begins proximally n1=en:muscle weakness, lower limbs, during exercise | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=30 en:myopathic findings on biopsy have been occasionally reported --- r_associated #0: 30 --> en:muscle weakness begins proximally n1=en:myopathic findings on biopsy have been occasionally reported | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=30 en:neck and proximal limb muscle myopathy --- r_associated #0: 30 --> en:muscle weakness begins proximally n1=en:neck and proximal limb muscle myopathy | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=30 en:neonatal edema (in some patients) --- r_associated #0: 30 --> en:muscle weakness begins proximally n1=en:neonatal edema (in some patients) | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=30 en:no dystrophic changes --- r_associated #0: 30 --> en:muscle weakness begins proximally n1=en:no dystrophic changes | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=30 en:normal or increased truncal adipose tissue --- r_associated #0: 30 --> en:muscle weakness begins proximally n1=en:normal or increased truncal adipose tissue | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=30 en:pectoralis hypoplasia --- r_associated #0: 30 --> en:muscle weakness begins proximally n1=en:pectoralis hypoplasia | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=30 en:percussion-induced muscle mounding (muscle rippling) --- r_associated #0: 30 --> en:muscle weakness begins proximally n1=en:percussion-induced muscle mounding (muscle rippling) | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=30 en:progressive distal muscle weakness --- r_associated #0: 30 --> en:muscle weakness begins proximally n1=en:progressive distal muscle weakness | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=30 en:progressive interictal weakness is common --- r_associated #0: 30 --> en:muscle weakness begins proximally n1=en:progressive interictal weakness is common | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=30 en:prolonged endplate potentials --- r_associated #0: 30 --> en:muscle weakness begins proximally n1=en:prolonged endplate potentials | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=30 en:prominent involvement of the quadriceps femoris muscles --- r_associated #0: 30 --> en:muscle weakness begins proximally n1=en:prominent involvement of the quadriceps femoris muscles | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=30 en:prominent muscular appearance --- r_associated #0: 30 --> en:muscle weakness begins proximally n1=en:prominent muscular appearance | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=30 en:proximal limb muscle weakness (occurs later) --- r_associated #0: 30 --> en:muscle weakness begins proximally n1=en:proximal limb muscle weakness (occurs later) | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=30 en:proximal muscle weakness more severe than distal muscle weakness --- r_associated #0: 30 --> en:muscle weakness begins proximally n1=en:proximal muscle weakness more severe than distal muscle weakness | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=30 en:repetitive response to single nerve stimulation --- r_associated #0: 30 --> en:muscle weakness begins proximally n1=en:repetitive response to single nerve stimulation | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=30 en:respiratory distress (congenital form) --- r_associated #0: 30 --> en:muscle weakness begins proximally n1=en:respiratory distress (congenital form) | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=30 en:scattered necrotic fibers --- r_associated #0: 30 --> en:muscle weakness begins proximally n1=en:scattered necrotic fibers | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=30 en:secondary loss of sarcolemmal caveolin-3 --- r_associated #0: 30 --> en:muscle weakness begins proximally n1=en:secondary loss of sarcolemmal caveolin-3 | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=30 en:shoulder weakness --- r_associated #0: 30 --> en:muscle weakness begins proximally n1=en:shoulder weakness | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=30 en:shoulder weakness and atrophy --- r_associated #0: 30 --> en:muscle weakness begins proximally n1=en:shoulder weakness and atrophy | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=30 en:skeletal muscle biopsy shows dystrophic changes --- r_associated #0: 30 --> en:muscle weakness begins proximally n1=en:skeletal muscle biopsy shows dystrophic changes | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=30 en:some subcutaneous adipose tissue may remain on upper arms --- r_associated #0: 30 --> en:muscle weakness begins proximally n1=en:some subcutaneous adipose tissue may remain on upper arms | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=30 en:swelling of the affected areas --- r_associated #0: 30 --> en:muscle weakness begins proximally n1=en:swelling of the affected areas | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=30 en:tubulofilamentous inclusions --- r_associated #0: 30 --> en:muscle weakness begins proximally n1=en:tubulofilamentous inclusions | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=30 en:type 2 fiber hypertrophy --- r_associated #0: 30 --> en:muscle weakness begins proximally n1=en:type 2 fiber hypertrophy | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=30 en:type 2 muscle fiber atrophy --- r_associated #0: 30 --> en:muscle weakness begins proximally n1=en:type 2 muscle fiber atrophy | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=30 en:upper limb muscle hypoplasia --- r_associated #0: 30 --> en:muscle weakness begins proximally n1=en:upper limb muscle hypoplasia | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=30 en:uterine muscle may be stiff during pregnancy --- r_associated #0: 30 --> en:muscle weakness begins proximally n1=en:uterine muscle may be stiff during pregnancy | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=30 en:vacuoles in the myofiber cytoplasm --- r_associated #0: 30 --> en:muscle weakness begins proximally n1=en:vacuoles in the myofiber cytoplasm | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=30 en:abnormal mitochondria in skeletal muscle biopsy --- r_associated #0: 29 --> en:muscle weakness begins proximally n1=en:abnormal mitochondria in skeletal muscle biopsy | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=29 en:biopsy shows nonspecific myopathy without rimmed vacuoles --- r_associated #0: 29 --> en:muscle weakness begins proximally n1=en:biopsy shows nonspecific myopathy without rimmed vacuoles | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=29 en:by fourth decade, many patients need help with ambulation --- r_associated #0: 29 --> en:muscle weakness begins proximally n1=en:by fourth decade, many patients need help with ambulation | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=29 en:calf muscle discomfort --- r_associated #0: 29 --> en:muscle weakness begins proximally n1=en:calf muscle discomfort | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=29 en:calf muscle hypertrophy --- r_associated #0: 29 --> en:muscle weakness begins proximally n1=en:calf muscle hypertrophy | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=29 en:calf muscle pseudohypertrophy --- r_associated #0: 29 --> en:muscle weakness begins proximally n1=en:calf muscle pseudohypertrophy | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=29 en:changes in sarcoplasmic reticulum and t-tubules --- r_associated #0: 29 --> en:muscle weakness begins proximally n1=en:changes in sarcoplasmic reticulum and t-tubules | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=29 en:cytochrome c oxidase-negative fibers --- r_associated #0: 29 --> en:muscle weakness begins proximally n1=en:cytochrome c oxidase-negative fibers | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=29 en:decreased cytochrome c oxidase staining --- r_associated #0: 29 --> en:muscle weakness begins proximally n1=en:decreased cytochrome c oxidase staining | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=29 en:decreased or patchy amounts of alpha-dystrobrevin and beta-2-syntrophin at the sarcolemma --- r_associated #0: 29 --> en:muscle weakness begins proximally n1=en:decreased or patchy amounts of alpha-dystrobrevin and beta-2-syntrophin at the sarcolemma | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=29 en:degenerative changes with increased connective tissue --- r_associated #0: 29 --> en:muscle weakness begins proximally n1=en:degenerative changes with increased connective tissue | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=29 en:difficulty climbing stairs, jumping, running --- r_associated #0: 29 --> en:muscle weakness begins proximally n1=en:difficulty climbing stairs, jumping, running | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=29 en:distal muscle atrophy due to neurologic disease --- r_associated #0: 29 --> en:muscle weakness begins proximally n1=en:distal muscle atrophy due to neurologic disease | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=29 en:distal weakness, upper and lower limbs (variable) --- r_associated #0: 29 --> en:muscle weakness begins proximally n1=en:distal weakness, upper and lower limbs (variable) | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=29 en:dystrophic features --- r_associated #0: 29 --> en:muscle weakness begins proximally n1=en:dystrophic features | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=29 en:fatty infiltration of affected muscles --- r_associated #0: 29 --> en:muscle weakness begins proximally n1=en:fatty infiltration of affected muscles | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=29 en:fiber size variation --- r_associated #0: 29 --> en:muscle weakness begins proximally n1=en:fiber size variation | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=29 en:handgrip myotonia --- r_associated #0: 29 --> en:muscle weakness begins proximally n1=en:handgrip myotonia | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=29 en:hyaline plaques with absent oxidative activity --- r_associated #0: 29 --> en:muscle weakness begins proximally n1=en:hyaline plaques with absent oxidative activity | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=29 en:hypotonia (untreated hypothyroidism) --- r_associated #0: 29 --> en:muscle weakness begins proximally n1=en:hypotonia (untreated hypothyroidism) | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=29 en:increased centralized internal nuclei --- r_associated #0: 29 --> en:muscle weakness begins proximally n1=en:increased centralized internal nuclei | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=29 en:increased fatty infiltration --- r_associated #0: 29 --> en:muscle weakness begins proximally n1=en:increased fatty infiltration | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=29 en:increased glycogen in muscle (but to a lesser extent than in the heart) --- r_associated #0: 29 --> en:muscle weakness begins proximally n1=en:increased glycogen in muscle (but to a lesser extent than in the heart) | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=29 en:independent walking may not be achieved --- r_associated #0: 29 --> en:muscle weakness begins proximally n1=en:independent walking may not be achieved | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=29 en:intrasarcoplasmic dense granulofilamentous aggregates that are immunoreactive with desmin --- r_associated #0: 29 --> en:muscle weakness begins proximally n1=en:intrasarcoplasmic dense granulofilamentous aggregates that are immunoreactive with desmin | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=29 en:limb weakness and atrophy --- r_associated #0: 29 --> en:muscle weakness begins proximally n1=en:limb weakness and atrophy | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=29 en:lymphedema, hands (rare) --- r_associated #0: 29 --> en:muscle weakness begins proximally n1=en:lymphedema, hands (rare) | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=29 en:marked muscular hypertrophy --- r_associated #0: 29 --> en:muscle weakness begins proximally n1=en:marked muscular hypertrophy | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=29 en:minimal muscle mass --- r_associated #0: 29 --> en:muscle weakness begins proximally n1=en:minimal muscle mass | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=29 en:mitochondrial paracrystalline inclusion bodies --- r_associated #0: 29 --> en:muscle weakness begins proximally n1=en:mitochondrial paracrystalline inclusion bodies | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=29 en:muscle atrophy (variable) --- r_associated #0: 29 --> en:muscle weakness begins proximally n1=en:muscle atrophy (variable) | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=29 en:muscle atrophy later in the disease --- r_associated #0: 29 --> en:muscle weakness begins proximally n1=en:muscle atrophy later in the disease | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=29 en:muscle atrophy, lower limbs more affected than upper limbs --- r_associated #0: 29 --> en:muscle weakness begins proximally n1=en:muscle atrophy, lower limbs more affected than upper limbs | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=29 en:muscle biopsy in acute stage shows increased numbers of abnormal mitochondria --- r_associated #0: 29 --> en:muscle weakness begins proximally n1=en:muscle biopsy in acute stage shows increased numbers of abnormal mitochondria | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=29 en:muscle biopsy shows disruption of the sarcolemmal membrane --- r_associated #0: 29 --> en:muscle weakness begins proximally n1=en:muscle biopsy shows disruption of the sarcolemmal membrane | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=29 en:muscle biopsy shows fiber type disproportion --- r_associated #0: 29 --> en:muscle weakness begins proximally n1=en:muscle biopsy shows fiber type disproportion | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=29 en:muscle biopsy shows hypotrophy of type 1 muscle fibers --- r_associated #0: 29 --> en:muscle weakness begins proximally n1=en:muscle biopsy shows hypotrophy of type 1 muscle fibers | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=29 en:muscle biopsy shows loss of myofibrillar organization --- r_associated #0: 29 --> en:muscle weakness begins proximally n1=en:muscle biopsy shows loss of myofibrillar organization | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=29 en:muscle biopsy shows myofiber degeneration --- r_associated #0: 29 --> en:muscle weakness begins proximally n1=en:muscle biopsy shows myofiber degeneration | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=29 en:muscle biopsy shows myopathic changes --- r_associated #0: 29 --> en:muscle weakness begins proximally n1=en:muscle biopsy shows myopathic changes | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=29 en:muscle stiffness or aching --- r_associated #0: 29 --> en:muscle weakness begins proximally n1=en:muscle stiffness or aching | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=29 en:muscle weakness and atrophy may be asymmetric --- r_associated #0: 29 --> en:muscle weakness begins proximally n1=en:muscle weakness and atrophy may be asymmetric | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=29 en:muscle weakness in forearm muscles --- r_associated #0: 29 --> en:muscle weakness begins proximally n1=en:muscle weakness in forearm muscles | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=29 en:muscle weakness of the face and neck, mild to moderate --- r_associated #0: 29 --> en:muscle weakness begins proximally n1=en:muscle weakness of the face and neck, mild to moderate | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=29 en:muscle weakness, predominantly proximal --- r_associated #0: 29 --> en:muscle weakness begins proximally n1=en:muscle weakness, predominantly proximal | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=29 en:muscle weakness, proximal, limb-girdle --- r_associated #0: 29 --> en:muscle weakness begins proximally n1=en:muscle weakness, proximal, limb-girdle | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=29 en:muscle weakness, proximal, slowly progressive --- r_associated #0: 29 --> en:muscle weakness begins proximally n1=en:muscle weakness, proximal, slowly progressive | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=29 en:myopathy, mild to severe --- r_associated #0: 29 --> en:muscle weakness begins proximally n1=en:myopathy, mild to severe | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=29 en:myotonia is present in majority of cases --- r_associated #0: 29 --> en:muscle weakness begins proximally n1=en:myotonia is present in majority of cases | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=29 en:myotonic discharges --- r_associated #0: 29 --> en:muscle weakness begins proximally n1=en:myotonic discharges | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=29 en:neurogenic atrophy seen on muscle biopsy --- r_associated #0: 29 --> en:muscle weakness begins proximally n1=en:neurogenic atrophy seen on muscle biopsy | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=29 en:no muscle fiber necrosis --- r_associated #0: 29 --> en:muscle weakness begins proximally n1=en:no muscle fiber necrosis | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=29 en:no ragged-red fibers --- r_associated #0: 29 --> en:muscle weakness begins proximally n1=en:no ragged-red fibers | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=29 en:no rods --- r_associated #0: 29 --> en:muscle weakness begins proximally n1=en:no rods | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=29 en:nonspecific muscle fiber atrophy --- r_associated #0: 29 --> en:muscle weakness begins proximally n1=en:nonspecific muscle fiber atrophy | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=29 en:normal dystrophin immunostaining --- r_associated #0: 29 --> en:muscle weakness begins proximally n1=en:normal dystrophin immunostaining | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=29 en:onset of lymphedema around puberty --- r_associated #0: 29 --> en:muscle weakness begins proximally n1=en:onset of lymphedema around puberty | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=29 en:painful muscle cramps --- r_associated #0: 29 --> en:muscle weakness begins proximally n1=en:painful muscle cramps | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=29 en:paradoxical myotonia (myotonia increases with exercise) --- r_associated #0: 29 --> en:muscle weakness begins proximally n1=en:paradoxical myotonia (myotonia increases with exercise) | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=29 en:partial lipodystrophy (abnormal distribution of subcutaneous adipose tissue) --- r_associated #0: 29 --> en:muscle weakness begins proximally n1=en:partial lipodystrophy (abnormal distribution of subcutaneous adipose tissue) | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=29 en:plaques immunoreactive for desmin and alpha-beta-crystallin --- r_associated #0: 29 --> en:muscle weakness begins proximally n1=en:plaques immunoreactive for desmin and alpha-beta-crystallin | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=29 en:prominent involvement of the biceps brachii muscles --- r_associated #0: 29 --> en:muscle weakness begins proximally n1=en:prominent involvement of the biceps brachii muscles | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=29 en:proximal and distal muscle atrophy --- r_associated #0: 29 --> en:muscle weakness begins proximally n1=en:proximal and distal muscle atrophy | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=29 en:proximal lower limb amyotrophy --- r_associated #0: 29 --> en:muscle weakness begins proximally n1=en:proximal lower limb amyotrophy | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=29 en:proximal muscle weakness in upper limbs --- r_associated #0: 29 --> en:muscle weakness begins proximally n1=en:proximal muscle weakness in upper limbs | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=29 en:proximal muscle weakness, upper and lower limbs, due to peripheral neuropathy, later in disease course --- r_associated #0: 29 --> en:muscle weakness begins proximally n1=en:proximal muscle weakness, upper and lower limbs, due to peripheral neuropathy, later in disease course | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=29 en:pseudoathletic appearance with prominent muscles before disease onset --- r_associated #0: 29 --> en:muscle weakness begins proximally n1=en:pseudoathletic appearance with prominent muscles before disease onset | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=29 en:reduced muscle tone --- r_associated #0: 29 --> en:muscle weakness begins proximally n1=en:reduced muscle tone | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=29 en:rhabdomyolysis, episodic and recurrent --- r_associated #0: 29 --> en:muscle weakness begins proximally n1=en:rhabdomyolysis, episodic and recurrent | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=29 en:secondary myopathic features --- r_associated #0: 29 --> en:muscle weakness begins proximally n1=en:secondary myopathic features | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=29 en:shortening of various muscle-tendon groups in feet --- r_associated #0: 29 --> en:muscle weakness begins proximally n1=en:shortening of various muscle-tendon groups in feet | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=29 en:smooth muscle may also become involved --- r_associated #0: 29 --> en:muscle weakness begins proximally n1=en:smooth muscle may also become involved | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=29 en:sparing of the anterior tibial compartment --- r_associated #0: 29 --> en:muscle weakness begins proximally n1=en:sparing of the anterior tibial compartment | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=29 en:subsarcolemmal accumulation of enlarged mitochondria with variably sized rectangular or elongated rhomboidal paracrystalline inclusions --- r_associated #0: 29 --> en:muscle weakness begins proximally n1=en:subsarcolemmal accumulation of enlarged mitochondria with variably sized rectangular or elongated rhomboidal paracrystalline inclusions | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=29 en:thickened subcutaneous tissue --- r_associated #0: 29 --> en:muscle weakness begins proximally n1=en:thickened subcutaneous tissue | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=29 en:transient neonatal hypotonia (less common) --- r_associated #0: 29 --> en:muscle weakness begins proximally n1=en:transient neonatal hypotonia (less common) | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=29 en:tremor at birth, involving most skeletal muscle groups, especially jaw muscles and lower limb muscles --- r_associated #0: 29 --> en:muscle weakness begins proximally n1=en:tremor at birth, involving most skeletal muscle groups, especially jaw muscles and lower limb muscles | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=29 en:upper limb weakness --- r_associated #0: 29 --> en:muscle weakness begins proximally n1=en:upper limb weakness | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=29 en:vacuoles appear to be exocytosing material at the cell surface --- r_associated #0: 29 --> en:muscle weakness begins proximally n1=en:vacuoles appear to be exocytosing material at the cell surface | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=29 en:vacuoles are autophagocytic and contain granular and membranous cellular debris --- r_associated #0: 29 --> en:muscle weakness begins proximally n1=en:vacuoles are autophagocytic and contain granular and membranous cellular debris | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=29 en:variation of fiber size and shape --- r_associated #0: 29 --> en:muscle weakness begins proximally n1=en:variation of fiber size and shape | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=29 en:variation of myofiber diameter --- r_associated #0: 29 --> en:muscle weakness begins proximally n1=en:variation of myofiber diameter | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=29 en:weakness of anterior compartment tibial muscles --- r_associated #0: 29 --> en:muscle weakness begins proximally n1=en:weakness of anterior compartment tibial muscles | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=29 en:widening of the synaptic cleft --- r_associated #0: 29 --> en:muscle weakness begins proximally n1=en:widening of the synaptic cleft | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=29 en:abnormal aggregation of mitochondria --- r_associated #0: 28 --> en:muscle weakness begins proximally n1=en:abnormal aggregation of mitochondria | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=28 en:absence of immunostaining for alpha- and beta-dystroglycan (family b) --- r_associated #0: 28 --> en:muscle weakness begins proximally n1=en:absence of immunostaining for alpha- and beta-dystroglycan (family b) | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=28 en:angulated atrophic muscle fibers --- r_associated #0: 28 --> en:muscle weakness begins proximally n1=en:angulated atrophic muscle fibers | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=28 en:atrophy of ankle and toe extensor (dorsiflexor) muscles --- r_associated #0: 28 --> en:muscle weakness begins proximally n1=en:atrophy of ankle and toe extensor (dorsiflexor) muscles | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=28 en:calf pseudohypertrophy rare --- r_associated #0: 28 --> en:muscle weakness begins proximally n1=en:calf pseudohypertrophy rare | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=28 en:congophilic staining --- r_associated #0: 28 --> en:muscle weakness begins proximally n1=en:congophilic staining | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=28 en:decreased quantal release --- r_associated #0: 28 --> en:muscle weakness begins proximally n1=en:decreased quantal release | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=28 en:decreased shank muscle mass --- r_associated #0: 28 --> en:muscle weakness begins proximally n1=en:decreased shank muscle mass | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=28 en:decreased thiamine pyrophosphate --- r_associated #0: 28 --> en:muscle weakness begins proximally n1=en:decreased thiamine pyrophosphate | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=28 en:deep finger muscle weakness --- r_associated #0: 28 --> en:muscle weakness begins proximally n1=en:deep finger muscle weakness | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=28 en:defective mitochondrial oxidative phosphorylation of multiple enzymes --- r_associated #0: 28 --> en:muscle weakness begins proximally n1=en:defective mitochondrial oxidative phosphorylation of multiple enzymes | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=28 en:distal muscle weakness in lower limbs, severe --- r_associated #0: 28 --> en:muscle weakness begins proximally n1=en:distal muscle weakness in lower limbs, severe | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=28 en:electron microscopy shows subsarcolemmal accumulations of abnormally shaped mitochondria --- r_associated #0: 28 --> en:muscle weakness begins proximally n1=en:electron microscopy shows subsarcolemmal accumulations of abnormally shaped mitochondria | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=28 en:enlarged mitochondria --- r_associated #0: 28 --> en:muscle weakness begins proximally n1=en:enlarged mitochondria | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=28 en:exercise intolerance (less common) --- r_associated #0: 28 --> en:muscle weakness begins proximally n1=en:exercise intolerance (less common) | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=28 en:exercise-induced muscle fatigue --- r_associated #0: 28 --> en:muscle weakness begins proximally n1=en:exercise-induced muscle fatigue | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=28 en:fatty replacement --- r_associated #0: 28 --> en:muscle weakness begins proximally n1=en:fatty replacement | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=28 en:gait abnormalities (occurs later) --- r_associated #0: 28 --> en:muscle weakness begins proximally n1=en:gait abnormalities (occurs later) | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=28 en:generalized lack of subcutaneous fat --- r_associated #0: 28 --> en:muscle weakness begins proximally n1=en:generalized lack of subcutaneous fat | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=28 en:generalized limb muscle atrophy --- r_associated #0: 28 --> en:muscle weakness begins proximally n1=en:generalized limb muscle atrophy | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=28 en:hangrip myotonia --- r_associated #0: 28 --> en:muscle weakness begins proximally n1=en:hangrip myotonia | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=28 en:hip girdle muscle atrophy --- r_associated #0: 28 --> en:muscle weakness begins proximally n1=en:hip girdle muscle atrophy | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=28 en:humeroperoneal weakness and atrophy --- r_associated #0: 28 --> en:muscle weakness begins proximally n1=en:humeroperoneal weakness and atrophy | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=28 en:hypotonia, generalized, severe --- r_associated #0: 28 --> en:muscle weakness begins proximally n1=en:hypotonia, generalized, severe | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=28 en:hypotrophy of type 1 fibers --- r_associated #0: 28 --> en:muscle weakness begins proximally n1=en:hypotrophy of type 1 fibers | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=28 en:imaging shows progressive fatty infiltration of muscle --- r_associated #0: 28 --> en:muscle weakness begins proximally n1=en:imaging shows progressive fatty infiltration of muscle | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=28 en:inability to stand or walk (in severe cases) --- r_associated #0: 28 --> en:muscle weakness begins proximally n1=en:inability to stand or walk (in severe cases) | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=28 en:inclusion body myopathy --- r_associated #0: 28 --> en:muscle weakness begins proximally n1=en:inclusion body myopathy | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=28 en:increased connective tissue and fat --- r_associated #0: 28 --> en:muscle weakness begins proximally n1=en:increased connective tissue and fat | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=28 en:increased fibrosis (family a) --- r_associated #0: 28 --> en:muscle weakness begins proximally n1=en:increased fibrosis (family a) | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=28 en:increased muscle lipid content --- r_associated #0: 28 --> en:muscle weakness begins proximally n1=en:increased muscle lipid content | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=28 en:increased variation in fiber size (in some patients) --- r_associated #0: 28 --> en:muscle weakness begins proximally n1=en:increased variation in fiber size (in some patients) | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=28 en:large hypertrophied fibers --- r_associated #0: 28 --> en:muscle weakness begins proximally n1=en:large hypertrophied fibers | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=28 en:loss of ambulation --- r_associated #0: 28 --> en:muscle weakness begins proximally n1=en:loss of ambulation | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=28 en:loss of antigravity strength --- r_associated #0: 28 --> en:muscle weakness begins proximally n1=en:loss of antigravity strength | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=28 en:lymphangitis, episodic --- r_associated #0: 28 --> en:muscle weakness begins proximally n1=en:lymphangitis, episodic | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=28 en:lymphedema (lower limb) --- r_associated #0: 28 --> en:muscle weakness begins proximally n1=en:lymphedema (lower limb) | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=28 en:marked predominance of slow-twitch, oxidative (type 1) muscle fibers --- r_associated #0: 28 --> en:muscle weakness begins proximally n1=en:marked predominance of slow-twitch, oxidative (type 1) muscle fibers | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=28 en:merosin-positive biopsy --- r_associated #0: 28 --> en:muscle weakness begins proximally n1=en:merosin-positive biopsy | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=28 en:muscle atrophy appears later in disease course --- r_associated #0: 28 --> en:muscle weakness begins proximally n1=en:muscle atrophy appears later in disease course | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=28 en:muscle biopsy shows degenerating endplates and junctional folds --- r_associated #0: 28 --> en:muscle weakness begins proximally n1=en:muscle biopsy shows degenerating endplates and junctional folds | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=28 en:muscle biopsy shows neurogenic atrophy --- r_associated #0: 28 --> en:muscle weakness begins proximally n1=en:muscle biopsy shows neurogenic atrophy | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=28 en:muscle biopsy shows neurogenic atrophy (1 patient) --- r_associated #0: 28 --> en:muscle weakness begins proximally n1=en:muscle biopsy shows neurogenic atrophy (1 patient) | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=28 en:muscle biopsy shows small fibers with central nuclei and accumulation of mitochondria in the central part of the fibers --- r_associated #0: 28 --> en:muscle weakness begins proximally n1=en:muscle biopsy shows small fibers with central nuclei and accumulation of mitochondria in the central part of the fibers | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=28 en:muscle biopsy shows small, membrane-bound vacuoles predominantly in type 2 fibers --- r_associated #0: 28 --> en:muscle weakness begins proximally n1=en:muscle biopsy shows small, membrane-bound vacuoles predominantly in type 2 fibers | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=28 en:muscle fiber regeneration --- r_associated #0: 28 --> en:muscle weakness begins proximally n1=en:muscle fiber regeneration | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=28 en:muscle wasting in lower limbs --- r_associated #0: 28 --> en:muscle weakness begins proximally n1=en:muscle wasting in lower limbs | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=28 en:muscle weakness, distal, particularly affecting the hands --- r_associated #0: 28 --> en:muscle weakness begins proximally n1=en:muscle weakness, distal, particularly affecting the hands | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=28 en:muscles do not contract upon electrical stimulation --- r_associated #0: 28 --> en:muscle weakness begins proximally n1=en:muscles do not contract upon electrical stimulation | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=28 en:myalgia (in some patients) --- r_associated #0: 28 --> en:muscle weakness begins proximally n1=en:myalgia (in some patients) | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=28 en:myopathy in approximately 45% of patients --- r_associated #0: 28 --> en:muscle weakness begins proximally n1=en:myopathy in approximately 45% of patients | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=28 en:neurogenic atrophy of muscle fibers seen on biopsy (in some patients) --- r_associated #0: 28 --> en:muscle weakness begins proximally n1=en:neurogenic atrophy of muscle fibers seen on biopsy (in some patients) | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=28 en:onset of weakness in hands and feet --- r_associated #0: 28 --> en:muscle weakness begins proximally n1=en:onset of weakness in hands and feet | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=28 en:pectoralis major hypoplasia --- r_associated #0: 28 --> en:muscle weakness begins proximally n1=en:pectoralis major hypoplasia | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=28 en:pelvic girdle weakness and atrophy --- r_associated #0: 28 --> en:muscle weakness begins proximally n1=en:pelvic girdle weakness and atrophy | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=28 en:poor exercise tolerance --- r_associated #0: 28 --> en:muscle weakness begins proximally n1=en:poor exercise tolerance | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=28 en:preserved junctional folds --- r_associated #0: 28 --> en:muscle weakness begins proximally n1=en:preserved junctional folds | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=28 en:progression to wheelchair in fourth decade --- r_associated #0: 28 --> en:muscle weakness begins proximally n1=en:progression to wheelchair in fourth decade | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=28 en:ragged-red fibers seen on muscle biopsy --- r_associated #0: 28 --> en:muscle weakness begins proximally n1=en:ragged-red fibers seen on muscle biopsy | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=28 en:repetitive compound muscle action potentials (cmap) in response to single stimulus --- r_associated #0: 28 --> en:muscle weakness begins proximally n1=en:repetitive compound muscle action potentials (cmap) in response to single stimulus | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=28 en:rounded, atrophic fibers (family a) --- r_associated #0: 28 --> en:muscle weakness begins proximally n1=en:rounded, atrophic fibers (family a) | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=28 en:sarcoplasmic inclusions --- r_associated #0: 28 --> en:muscle weakness begins proximally n1=en:sarcoplasmic inclusions | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=28 en:secondarily decreased activities of mitochondrial respiratory enzymes (in some patients) --- r_associated #0: 28 --> en:muscle weakness begins proximally n1=en:secondarily decreased activities of mitochondrial respiratory enzymes (in some patients) | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=28 en:shortened open channel duration --- r_associated #0: 28 --> en:muscle weakness begins proximally n1=en:shortened open channel duration | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=28 en:shoulder muscle hypoplasia --- r_associated #0: 28 --> en:muscle weakness begins proximally n1=en:shoulder muscle hypoplasia | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=28 en:skeletal muscle shows dystrophic changes --- r_associated #0: 28 --> en:muscle weakness begins proximally n1=en:skeletal muscle shows dystrophic changes | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=28 en:small and incompletely fused muscle fibers seen on biopsy --- r_associated #0: 28 --> en:muscle weakness begins proximally n1=en:small and incompletely fused muscle fibers seen on biopsy | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=28 en:soft tissue vascular malformations --- r_associated #0: 28 --> en:muscle weakness begins proximally n1=en:soft tissue vascular malformations | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=28 en:some patients become wheelchair-dependent --- r_associated #0: 28 --> en:muscle weakness begins proximally n1=en:some patients become wheelchair-dependent | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=28 en:sparing of anterior tibialis muscle --- r_associated #0: 28 --> en:muscle weakness begins proximally n1=en:sparing of anterior tibialis muscle | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=28 en:subsarcolemmal accumulations of abnormally shaped mitochondria seen with electronmicroscopy --- r_associated #0: 28 --> en:muscle weakness begins proximally n1=en:subsarcolemmal accumulations of abnormally shaped mitochondria seen with electronmicroscopy | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=28 en:tremors subside over the first 2 to 3 months of life --- r_associated #0: 28 --> en:muscle weakness begins proximally n1=en:tremors subside over the first 2 to 3 months of life | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=28 en:tubulofilamentous nuclear or cytoplasmic inclusions on biopsy --- r_associated #0: 28 --> en:muscle weakness begins proximally n1=en:tubulofilamentous nuclear or cytoplasmic inclusions on biopsy | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=28 en:type 1 fiber predominance --- r_associated #0: 28 --> en:muscle weakness begins proximally n1=en:type 1 fiber predominance | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=28 en:vacuolar myopathy --- r_associated #0: 28 --> en:muscle weakness begins proximally n1=en:vacuolar myopathy | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=28 en:velopharyngeal muscle weakness --- r_associated #0: 28 --> en:muscle weakness begins proximally n1=en:velopharyngeal muscle weakness | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=28 en:wasting, especially temporal, neck, and facial muscles --- r_associated #0: 28 --> en:muscle weakness begins proximally n1=en:wasting, especially temporal, neck, and facial muscles | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=28 en:weakness of ankle and toe extensor (dorsiflexor) muscles --- r_associated #0: 28 --> en:muscle weakness begins proximally n1=en:weakness of ankle and toe extensor (dorsiflexor) muscles | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=28 en:weakness of ankle plantar flexion --- r_associated #0: 28 --> en:muscle weakness begins proximally n1=en:weakness of ankle plantar flexion | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=28 en:z-disks with abnormal homogeneous material --- r_associated #0: 28 --> en:muscle weakness begins proximally n1=en:z-disks with abnormal homogeneous material | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=28 en:a subset of patients develop bilateral weakness --- r_associated #0: 27 --> en:muscle weakness begins proximally n1=en:a subset of patients develop bilateral weakness | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=27 en:abnormal iron deposition in mitochondria --- r_associated #0: 27 --> en:muscle weakness begins proximally n1=en:abnormal iron deposition in mitochondria | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=27 en:abnormal mitochondria with loss of cristae --- r_associated #0: 27 --> en:muscle weakness begins proximally n1=en:abnormal mitochondria with loss of cristae | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=27 en:amyloid deposition in muscle fibers occurs rarely --- r_associated #0: 27 --> en:muscle weakness begins proximally n1=en:amyloid deposition in muscle fibers occurs rarely | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=27 en:anterior tibial muscles first involved --- r_associated #0: 27 --> en:muscle weakness begins proximally n1=en:anterior tibial muscles first involved | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=27 en:apoptotic nuclei --- r_associated #0: 27 --> en:muscle weakness begins proximally n1=en:apoptotic nuclei | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=27 en:attacks precipitated by hypokalemia, administration of glucose or insulin, heavy carbohydrate consumption, stress, fatigue, rest after exercise --- r_associated #0: 27 --> en:muscle weakness begins proximally n1=en:attacks precipitated by hypokalemia, administration of glucose or insulin, heavy carbohydrate consumption, stress, fatigue, rest after exercise | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=27 en:autophagic vacuoles with multilamellar structures seen on electron microscopy --- r_associated #0: 27 --> en:muscle weakness begins proximally n1=en:autophagic vacuoles with multilamellar structures seen on electron microscopy | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=27 en:bilateral facial weakness (congenital form) --- r_associated #0: 27 --> en:muscle weakness begins proximally n1=en:bilateral facial weakness (congenital form) | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=27 en:calf atrophy (later onset) --- r_associated #0: 27 --> en:muscle weakness begins proximally n1=en:calf atrophy (later onset) | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=27 en:chronic neurogenic changes seen on emg --- r_associated #0: 27 --> en:muscle weakness begins proximally n1=en:chronic neurogenic changes seen on emg | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=27 en:cranial muscles spared --- r_associated #0: 27 --> en:muscle weakness begins proximally n1=en:cranial muscles spared | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=27 en:decreased activity of cytochrome c oxidase in most cases seen on muscle biopsy --- r_associated #0: 27 --> en:muscle weakness begins proximally n1=en:decreased activity of cytochrome c oxidase in most cases seen on muscle biopsy | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=27 en:decreased caveolin-3 expression on muscle biopsy --- r_associated #0: 27 --> en:muscle weakness begins proximally n1=en:decreased caveolin-3 expression on muscle biopsy | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=27 en:decreased caveolin-3 expression seen on muscle biopsy --- r_associated #0: 27 --> en:muscle weakness begins proximally n1=en:decreased caveolin-3 expression seen on muscle biopsy | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=27 en:decreased numbers of acetylcholine receptors (achr) in the postsynaptic membrane (less than 50% of normal) --- r_associated #0: 27 --> en:muscle weakness begins proximally n1=en:decreased numbers of acetylcholine receptors (achr) in the postsynaptic membrane (less than 50% of normal) | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=27 en:decremental compound muscle action potential on repetitive stimulation --- r_associated #0: 27 --> en:muscle weakness begins proximally n1=en:decremental compound muscle action potential on repetitive stimulation | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=27 en:distal limb muscle atrophy (less common) --- r_associated #0: 27 --> en:muscle weakness begins proximally n1=en:distal limb muscle atrophy (less common) | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=27 en:distal lower limb muscle weakness and atrophy --- r_associated #0: 27 --> en:muscle weakness begins proximally n1=en:distal lower limb muscle weakness and atrophy | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=27 en:distal muscle atrophy, affecting the lower limbs --- r_associated #0: 27 --> en:muscle weakness begins proximally n1=en:distal muscle atrophy, affecting the lower limbs | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=27 en:distal muscle weakness due to peripheral neuropathy, lower limbs more affected than upper limbs --- r_associated #0: 27 --> en:muscle weakness begins proximally n1=en:distal muscle weakness due to peripheral neuropathy, lower limbs more affected than upper limbs | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=27 en:easy bruisability of lower extremities --- r_associated #0: 27 --> en:muscle weakness begins proximally n1=en:easy bruisability of lower extremities | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=27 en:edema at birth --- r_associated #0: 27 --> en:muscle weakness begins proximally n1=en:edema at birth | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=27 en:exercise-induced muscle stiffness --- r_associated #0: 27 --> en:muscle weakness begins proximally n1=en:exercise-induced muscle stiffness | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=27 en:fiber necrosis --- r_associated #0: 27 --> en:muscle weakness begins proximally n1=en:fiber necrosis | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=27 en:fiber type grouping --- r_associated #0: 27 --> en:muscle weakness begins proximally n1=en:fiber type grouping | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=27 en:foot dorsiflexor weakness --- r_associated #0: 27 --> en:muscle weakness begins proximally n1=en:foot dorsiflexor weakness | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=27 en:generalized muscle weakness, severe --- r_associated #0: 27 --> en:muscle weakness begins proximally n1=en:generalized muscle weakness, severe | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=27 en:generalized muscular appearance from birth --- r_associated #0: 27 --> en:muscle weakness begins proximally n1=en:generalized muscular appearance from birth | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=27 en:hamstring and quadriceps muscles mildly affected --- r_associated #0: 27 --> en:muscle weakness begins proximally n1=en:hamstring and quadriceps muscles mildly affected | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=27 en:hypothenar muscle atrophy --- r_associated #0: 27 --> en:muscle weakness begins proximally n1=en:hypothenar muscle atrophy | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=27 en:inability to jump or squat --- r_associated #0: 27 --> en:muscle weakness begins proximally n1=en:inability to jump or squat | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=27 en:increased central nucleation --- r_associated #0: 27 --> en:muscle weakness begins proximally n1=en:increased central nucleation | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=27 en:increased internal nuclei --- r_associated #0: 27 --> en:muscle weakness begins proximally n1=en:increased internal nuclei | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=27 en:increased perisarcolemmal calcium deposition --- r_associated #0: 27 --> en:muscle weakness begins proximally n1=en:increased perisarcolemmal calcium deposition | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=27 en:increased subcutaneous truncal adipose tissue --- r_associated #0: 27 --> en:muscle weakness begins proximally n1=en:increased subcutaneous truncal adipose tissue | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=27 en:increased variation in muscle fiber diameter --- r_associated #0: 27 --> en:muscle weakness begins proximally n1=en:increased variation in muscle fiber diameter | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=27 en:leg cramps may occur with exercise --- r_associated #0: 27 --> en:muscle weakness begins proximally n1=en:leg cramps may occur with exercise | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=27 en:lipoatrophy of trunk --- r_associated #0: 27 --> en:muscle weakness begins proximally n1=en:lipoatrophy of trunk | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=27 en:mild kinetic abnormalities of the achr (in some patients) --- r_associated #0: 27 --> en:muscle weakness begins proximally n1=en:mild kinetic abnormalities of the achr (in some patients) | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=27 en:minipolymyoclonus --- r_associated #0: 27 --> en:muscle weakness begins proximally n1=en:minipolymyoclonus | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=27 en:motor clumsiness --- r_associated #0: 27 --> en:muscle weakness begins proximally n1=en:motor clumsiness | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=27 en:muscle biopsy shows decrease or absence of cytochrome c oxidase --- r_associated #0: 27 --> en:muscle weakness begins proximally n1=en:muscle biopsy shows decrease or absence of cytochrome c oxidase | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=27 en:muscle biopsy shows decreased muscle-specific phosphorylase kinase activity --- r_associated #0: 27 --> en:muscle weakness begins proximally n1=en:muscle biopsy shows decreased muscle-specific phosphorylase kinase activity | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=27 en:muscle biopsy shows glycogen storage --- r_associated #0: 27 --> en:muscle weakness begins proximally n1=en:muscle biopsy shows glycogen storage | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=27 en:muscle biopsy shows mitochondrial paracrystalline inclusions --- r_associated #0: 27 --> en:muscle weakness begins proximally n1=en:muscle biopsy shows mitochondrial paracrystalline inclusions | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=27 en:muscle biopsy shows no dystrophic changes --- r_associated #0: 27 --> en:muscle weakness begins proximally n1=en:muscle biopsy shows no dystrophic changes | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=27 en:muscle fiber necrosis --- r_associated #0: 27 --> en:muscle weakness begins proximally n1=en:muscle fiber necrosis | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=27 en:muscle hyperirritability --- r_associated #0: 27 --> en:muscle weakness begins proximally n1=en:muscle hyperirritability | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=27 en:muscle pain and cramps following exercise --- r_associated #0: 27 --> en:muscle weakness begins proximally n1=en:muscle pain and cramps following exercise | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=27 en:muscle weakness, proximal and distal --- r_associated #0: 27 --> en:muscle weakness begins proximally n1=en:muscle weakness, proximal and distal | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=27 en:muscles become hard and tender during exercise --- r_associated #0: 27 --> en:muscle weakness begins proximally n1=en:muscles become hard and tender during exercise | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=27 en:myxedematous appearance --- r_associated #0: 27 --> en:muscle weakness begins proximally n1=en:myxedematous appearance | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=27 en:no lipodystrophy in face and neck --- r_associated #0: 27 --> en:muscle weakness begins proximally n1=en:no lipodystrophy in face and neck | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=27 en:normal or decreased facial and neck adipose tissue --- r_associated #0: 27 --> en:muscle weakness begins proximally n1=en:normal or decreased facial and neck adipose tissue | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=27 en:nuclear clumps --- r_associated #0: 27 --> en:muscle weakness begins proximally n1=en:nuclear clumps | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=27 en:pectoralis muscles may be less involved, leading to inward shrugging posture --- r_associated #0: 27 --> en:muscle weakness begins proximally n1=en:pectoralis muscles may be less involved, leading to inward shrugging posture | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=27 en:potassium sensitivity has been reported --- r_associated #0: 27 --> en:muscle weakness begins proximally n1=en:potassium sensitivity has been reported | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=27 en:progressive ectopic ossification (neck, dorsal trunk, proximal limbs, sternocleidomastoid, masseters) --- r_associated #0: 27 --> en:muscle weakness begins proximally n1=en:progressive ectopic ossification (neck, dorsal trunk, proximal limbs, sternocleidomastoid, masseters) | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=27 en:prominent musculature --- r_associated #0: 27 --> en:muscle weakness begins proximally n1=en:prominent musculature | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=27 en:proximal weakness --- r_associated #0: 27 --> en:muscle weakness begins proximally n1=en:proximal weakness | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=27 en:proximal weakness of the lower limbs with longer disease duration --- r_associated #0: 27 --> en:muscle weakness begins proximally n1=en:proximal weakness of the lower limbs with longer disease duration | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=27 en:ragged-red muscle fibers --- r_associated #0: 27 --> en:muscle weakness begins proximally n1=en:ragged-red muscle fibers | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=27 en:retain some mechanical adipose tissue (joints, orbits, palms, soles) --- r_associated #0: 27 --> en:muscle weakness begins proximally n1=en:retain some mechanical adipose tissue (joints, orbits, palms, soles) | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=27 en:rhabdomyolysis may occur --- r_associated #0: 27 --> en:muscle weakness begins proximally n1=en:rhabdomyolysis may occur | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=27 en:small nerve terminals --- r_associated #0: 27 --> en:muscle weakness begins proximally n1=en:small nerve terminals | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=27 en:sparing of small hand and finger muscles --- r_associated #0: 27 --> en:muscle weakness begins proximally n1=en:sparing of small hand and finger muscles | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=27 en:subsarcolemmal mitochondrial accumulation --- r_associated #0: 27 --> en:muscle weakness begins proximally n1=en:subsarcolemmal mitochondrial accumulation | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=27 en:type 1 and type 2 muscle fibers with 'minicore' regions of sarcomeric disorganization, lack of oxidative activity, and absent mitochondria --- r_associated #0: 27 --> en:muscle weakness begins proximally n1=en:type 1 and type 2 muscle fibers with 'minicore' regions of sarcomeric disorganization, lack of oxidative activity, and absent mitochondria | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=27 en:type 1 muscle fiber predominance --- r_associated #0: 27 --> en:muscle weakness begins proximally n1=en:type 1 muscle fiber predominance | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=27 en:usually no myopathic changes on biopsy --- r_associated #0: 27 --> en:muscle weakness begins proximally n1=en:usually no myopathic changes on biopsy | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=27 en:vacuoles are autophagocytic --- r_associated #0: 27 --> en:muscle weakness begins proximally n1=en:vacuoles are autophagocytic | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=27 en:weakness of the muscles in the anterior compartment of the lower leg (particularly the tibialis anterior muscle) --- r_associated #0: 27 --> en:muscle weakness begins proximally n1=en:weakness of the muscles in the anterior compartment of the lower leg (particularly the tibialis anterior muscle) | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=27 en:abnormal size and shape of synaptic endplates --- r_associated #0: 26 --> en:muscle weakness begins proximally n1=en:abnormal size and shape of synaptic endplates | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=26 en:almost complete absence of large diameter fibers --- r_associated #0: 26 --> en:muscle weakness begins proximally n1=en:almost complete absence of large diameter fibers | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=26 en:areflexia due to muscle weakness --- r_associated #0: 26 --> en:muscle weakness begins proximally n1=en:areflexia due to muscle weakness | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=26 en:centralized nuclei, rare --- r_associated #0: 26 --> en:muscle weakness begins proximally n1=en:centralized nuclei, rare | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=26 en:cores contain densely packed myofilaments --- r_associated #0: 26 --> en:muscle weakness begins proximally n1=en:cores contain densely packed myofilaments | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=26 en:decreased endplate potential and amplitudes --- r_associated #0: 26 --> en:muscle weakness begins proximally n1=en:decreased endplate potential and amplitudes | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=26 en:decreased hand grip strength --- r_associated #0: 26 --> en:muscle weakness begins proximally n1=en:decreased hand grip strength | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=26 en:decreased immunostaining for alpha-sarcoglycan --- r_associated #0: 26 --> en:muscle weakness begins proximally n1=en:decreased immunostaining for alpha-sarcoglycan | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=26 en:decreased lipoic acid --- r_associated #0: 26 --> en:muscle weakness begins proximally n1=en:decreased lipoic acid | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=26 en:decreased muscle bulk (in one patient) --- r_associated #0: 26 --> en:muscle weakness begins proximally n1=en:decreased muscle bulk (in one patient) | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=26 en:decremental compound muscle action potential (cmap) in response to repetitive nerve stimulation seen on emg --- r_associated #0: 26 --> en:muscle weakness begins proximally n1=en:decremental compound muscle action potential (cmap) in response to repetitive nerve stimulation seen on emg | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=26 en:degenerating junctional folds --- r_associated #0: 26 --> en:muscle weakness begins proximally n1=en:degenerating junctional folds | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=26 en:difficulty in toe walking --- r_associated #0: 26 --> en:muscle weakness begins proximally n1=en:difficulty in toe walking | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=26 en:difficulty walking on heels occurs prior to difficulty walking on toes --- r_associated #0: 26 --> en:muscle weakness begins proximally n1=en:difficulty walking on heels occurs prior to difficulty walking on toes | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=26 en:disorganization of the myofibrillar pattern --- r_associated #0: 26 --> en:muscle weakness begins proximally n1=en:disorganization of the myofibrillar pattern | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=26 en:dorsal and flexor muscles of the forearm are involved --- r_associated #0: 26 --> en:muscle weakness begins proximally n1=en:dorsal and flexor muscles of the forearm are involved | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=26 en:dystrophic changes may be present --- r_associated #0: 26 --> en:muscle weakness begins proximally n1=en:dystrophic changes may be present | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=26 en:dystrophic changes seen on skeletal muscle biopsy --- r_associated #0: 26 --> en:muscle weakness begins proximally n1=en:dystrophic changes seen on skeletal muscle biopsy | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=26 en:edema is present at birth and then slowly decreases --- r_associated #0: 26 --> en:muscle weakness begins proximally n1=en:edema is present at birth and then slowly decreases | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=26 en:edema reoccurs with infections --- r_associated #0: 26 --> en:muscle weakness begins proximally n1=en:edema reoccurs with infections | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=26 en:episodic, nonpruritic, nonurticarial, nonpitting edema --- r_associated #0: 26 --> en:muscle weakness begins proximally n1=en:episodic, nonpruritic, nonurticarial, nonpitting edema | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=26 en:fat pad anterior to malleolus --- r_associated #0: 26 --> en:muscle weakness begins proximally n1=en:fat pad anterior to malleolus | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=26 en:gastrocnemius and soleus muscles most affected --- r_associated #0: 26 --> en:muscle weakness begins proximally n1=en:gastrocnemius and soleus muscles most affected | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=26 en:generalized muscle weakness (less common) --- r_associated #0: 26 --> en:muscle weakness begins proximally n1=en:generalized muscle weakness (less common) | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=26 en:generalized neonatal hypotonia --- r_associated #0: 26 --> en:muscle weakness begins proximally n1=en:generalized neonatal hypotonia | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=26 en:gluteus maximus and thigh adductors most affected --- r_associated #0: 26 --> en:muscle weakness begins proximally n1=en:gluteus maximus and thigh adductors most affected | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=26 en:hyaline inclusion --- r_associated #0: 26 --> en:muscle weakness begins proximally n1=en:hyaline inclusion | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=26 en:hypertonia at birth --- r_associated #0: 26 --> en:muscle weakness begins proximally n1=en:hypertonia at birth | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=26 en:hypoplasia of cervical paravertebral muscles --- r_associated #0: 26 --> en:muscle weakness begins proximally n1=en:hypoplasia of cervical paravertebral muscles | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=26 en:hypotonia (2 patients) --- r_associated #0: 26 --> en:muscle weakness begins proximally n1=en:hypotonia (2 patients) | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=26 en:hypotonia, neonatal and later --- r_associated #0: 26 --> en:muscle weakness begins proximally n1=en:hypotonia, neonatal and later | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=26 en:increased internal nuclei (in some patients) --- r_associated #0: 26 --> en:muscle weakness begins proximally n1=en:increased internal nuclei (in some patients) | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=26 en:increased staining for myotilin, dystrophin, desmin --- r_associated #0: 26 --> en:muscle weakness begins proximally n1=en:increased staining for myotilin, dystrophin, desmin | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=26 en:internal nuclei (in some patients) --- r_associated #0: 26 --> en:muscle weakness begins proximally n1=en:internal nuclei (in some patients) | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=26 en:lack of antigravity movements (patient b) --- r_associated #0: 26 --> en:muscle weakness begins proximally n1=en:lack of antigravity movements (patient b) | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=26 en:lipohypoplasia, regional --- r_associated #0: 26 --> en:muscle weakness begins proximally n1=en:lipohypoplasia, regional | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=26 en:loss of ability to walk in early childhood --- r_associated #0: 26 --> en:muscle weakness begins proximally n1=en:loss of ability to walk in early childhood | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=26 en:low muscle mass --- r_associated #0: 26 --> en:muscle weakness begins proximally n1=en:low muscle mass | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=26 en:lymphedema of the lower limbs (swelling is confined to below the knees) --- r_associated #0: 26 --> en:muscle weakness begins proximally n1=en:lymphedema of the lower limbs (swelling is confined to below the knees) | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=26 en:mild endplate myopathy --- r_associated #0: 26 --> en:muscle weakness begins proximally n1=en:mild endplate myopathy | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=26 en:mild variability in muscle fiber size --- r_associated #0: 26 --> en:muscle weakness begins proximally n1=en:mild variability in muscle fiber size | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=26 en:minicore-like lesions with mitochondrial depletion and sarcomeric disorganization --- r_associated #0: 26 --> en:muscle weakness begins proximally n1=en:minicore-like lesions with mitochondrial depletion and sarcomeric disorganization | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=26 en:mitochondria show paracrystalline inclusions --- r_associated #0: 26 --> en:muscle weakness begins proximally n1=en:mitochondria show paracrystalline inclusions | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=26 en:muscle biopsy shows intranuclear tubulofilamentous inclusions --- r_associated #0: 26 --> en:muscle weakness begins proximally n1=en:muscle biopsy shows intranuclear tubulofilamentous inclusions | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=26 en:muscle biopsy shows mild dystrophic changes --- r_associated #0: 26 --> en:muscle weakness begins proximally n1=en:muscle biopsy shows mild dystrophic changes | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=26 en:muscle biopsy shows necrotic and regenerating fibers --- r_associated #0: 26 --> en:muscle weakness begins proximally n1=en:muscle biopsy shows necrotic and regenerating fibers | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=26 en:muscle biopsy shows rimmed vacuoles --- r_associated #0: 26 --> en:muscle weakness begins proximally n1=en:muscle biopsy shows rimmed vacuoles | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=26 en:muscle cramps affect the upper and lower limbs --- r_associated #0: 26 --> en:muscle weakness begins proximally n1=en:muscle cramps affect the upper and lower limbs | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=26 en:muscle fibers appear as fetal myotubules --- r_associated #0: 26 --> en:muscle weakness begins proximally n1=en:muscle fibers appear as fetal myotubules | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=26 en:muscle mounding --- r_associated #0: 26 --> en:muscle weakness begins proximally n1=en:muscle mounding | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=26 en:muscle stiffness (in older patients) --- r_associated #0: 26 --> en:muscle weakness begins proximally n1=en:muscle stiffness (in older patients) | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=26 en:muscle weakness and atrophy, proximal --- r_associated #0: 26 --> en:muscle weakness begins proximally n1=en:muscle weakness and atrophy, proximal | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=26 en:muscle weakness associated with fasting or infection --- r_associated #0: 26 --> en:muscle weakness begins proximally n1=en:muscle weakness associated with fasting or infection | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=26 en:muscle weakness is not a feature --- r_associated #0: 26 --> en:muscle weakness begins proximally n1=en:muscle weakness is not a feature | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=26 en:muscle weakness restricted to the upper limb --- r_associated #0: 26 --> en:muscle weakness begins proximally n1=en:muscle weakness restricted to the upper limb | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=26 en:muscle weakness, particularly of the lower limbs --- r_associated #0: 26 --> en:muscle weakness begins proximally n1=en:muscle weakness, particularly of the lower limbs | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=26 en:myofibrillar disintegration --- r_associated #0: 26 --> en:muscle weakness begins proximally n1=en:myofibrillar disintegration | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=26 en:myofibrillar lesions --- r_associated #0: 26 --> en:muscle weakness begins proximally n1=en:myofibrillar lesions | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=26 en:myotonia, potassium-sensitive (may be responsive to acetazolamide) --- r_associated #0: 26 --> en:muscle weakness begins proximally n1=en:myotonia, potassium-sensitive (may be responsive to acetazolamide) | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=26 en:neck flexor weakness --- r_associated #0: 26 --> en:muscle weakness begins proximally n1=en:neck flexor weakness | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=26 en:necrotic and atrophic fibers with centralized nuclei seen on muscle biopsy --- r_associated #0: 26 --> en:muscle weakness begins proximally n1=en:necrotic and atrophic fibers with centralized nuclei seen on muscle biopsy | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=26 en:necrotic and regenerating muscle fibers --- r_associated #0: 26 --> en:muscle weakness begins proximally n1=en:necrotic and regenerating muscle fibers | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=26 en:nemaline bodies are usually subsarcolemmal or sarcoplasmic --- r_associated #0: 26 --> en:muscle weakness begins proximally n1=en:nemaline bodies are usually subsarcolemmal or sarcoplasmic | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=26 en:pelvic muscle involvement occurs later --- r_associated #0: 26 --> en:muscle weakness begins proximally n1=en:pelvic muscle involvement occurs later | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=26 en:progressive distal and proximal symmetric limb weakness --- r_associated #0: 26 --> en:muscle weakness begins proximally n1=en:progressive distal and proximal symmetric limb weakness | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=26 en:proximal upper limb amyotrophy --- r_associated #0: 26 --> en:muscle weakness begins proximally n1=en:proximal upper limb amyotrophy | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=26 en:ragged red fibers seen on skeletal muscle biopsy --- r_associated #0: 26 --> en:muscle weakness begins proximally n1=en:ragged red fibers seen on skeletal muscle biopsy | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=26 en:reduced muscle bulk --- r_associated #0: 26 --> en:muscle weakness begins proximally n1=en:reduced muscle bulk | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=26 en:replacement of affected muscle tissue with fatty tissue --- r_associated #0: 26 --> en:muscle weakness begins proximally n1=en:replacement of affected muscle tissue with fatty tissue | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=26 en:scapuloperoneal amyotrophy --- r_associated #0: 26 --> en:muscle weakness begins proximally n1=en:scapuloperoneal amyotrophy | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=26 en:shortening of flexor profundus muscle-tendon unit --- r_associated #0: 26 --> en:muscle weakness begins proximally n1=en:shortening of flexor profundus muscle-tendon unit | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=26 en:skeletal muscle biopsy shows impaired respiratory oxidation --- r_associated #0: 26 --> en:muscle weakness begins proximally n1=en:skeletal muscle biopsy shows impaired respiratory oxidation | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=26 en:slow motor responses to sudden events (i.e., falling) --- r_associated #0: 26 --> en:muscle weakness begins proximally n1=en:slow motor responses to sudden events (i.e., falling) | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=26 en:subsarcolemmal hyaline bodies in type 1 fibers only --- r_associated #0: 26 --> en:muscle weakness begins proximally n1=en:subsarcolemmal hyaline bodies in type 1 fibers only | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=26 en:thickening of the fascial structures of the palm and fingers --- r_associated #0: 26 --> en:muscle weakness begins proximally n1=en:thickening of the fascial structures of the palm and fingers | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=26 en:variable decreases in mitochondrial respiratory complex enzyme activities --- r_associated #0: 26 --> en:muscle weakness begins proximally n1=en:variable decreases in mitochondrial respiratory complex enzyme activities | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=26 en:variation in fibrodiameter seen on muscle biopsy --- r_associated #0: 26 --> en:muscle weakness begins proximally n1=en:variation in fibrodiameter seen on muscle biopsy | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=26 en:variation in skeletal muscle fiber diameter --- r_associated #0: 26 --> en:muscle weakness begins proximally n1=en:variation in skeletal muscle fiber diameter | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=26 altération cavitaire --- r_associated #0: 23 --> en:muscle weakness begins proximally n1=altération cavitaire | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=23 dégénérescence cavitaire --- r_associated #0: 22 --> en:muscle weakness begins proximally n1=dégénérescence cavitaire | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=22 dégénérescence vacuolaire --- r_associated #0: 21 --> en:muscle weakness begins proximally n1=dégénérescence vacuolaire | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=21 % production --- r_associated #0: -5 --> en:muscle weakness begins proximally n1=% production | n2=en:muscle weakness begins proximally | rel=r_associated | relid=0 | w=-5