Le Diko - en:distal muscle atrophy due to neuropathy

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Le Diko - en:distal muscle atrophy due to neuropathy

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en:distal muscle atrophy due to neuropathy

Nom

Informations lexicales

Langue:anglais

Associations d'idées

1000

en:variation in skeletal muscle fiber diameter

•

en:muscle fiber splitting and fibrosis seen on muscle biopsy

•

en:soft tissue vascular malformations

•

•

en:attacks usually decrease or disappear after age 40 years

•

en:decreased activity of mitochondrial respiratory complexes i, iii, and iv in muscle tissue

•

en:decreased muscle mass (especially of limbs)

•

en:endplate myopathy

•

en:gluteal hypoplasia

•

en:loss of subcutaneous fat, diffuse

•

en:minicores (in some)

•

en:muscle biopsy shows dystrophic features (later in disease course)

•

en:abnormal mitochondria

•

en:plantar fibromatosis

•

en:rectus abdominis muscle separation

•

en:subsarcolemmal hyaline bodies in type 1 fibers only

•

en:type 1 muscle fiber predominance

•

en:emg shows myopathic changes

•

en:hypoplasia of serratus anterior muscle

•

en:hypotonia, generalized (in some patients)

•

en:lipoatrophic appearance

•

en:lipomas or lipomatous masses (most cases)

•

•

en:reduced subcutaneous adipose tissue

•

en:difficulty standing

•

en:postsynaptic abnormalities

•

en:proximal muscle weakness in upper limbs

•

en:skeletal muscle shows dystrophic changes

•

en:thin musculature

•

en:internal nuclei seen on muscle biopsy

•

en:repetitive compound muscle action potentials (cmap) in response to single stimulus

•

en:vacuolated muscle fibers show reduplication of the basement membrane

•

en:distal muscle weakness due to peripheral neuropathy of upper and lower limbs

•

en:increased connective tissue and fat

•

en:multiple mitochondrial dna (mtdna) deletions (in most cases)

•

en:mitochondrial myopathies

•

en:low muscle mass

•

en:loss of ambulation (in some patients)

•

en:gowers sign (patient a)

•

en:hypoplasia of infraspinatus muscle

•

en:hamstring muscle affected

•

en:dorsal and flexor muscles of the forearm are involved

•

en:distal lower limb muscle weakness and atrophy

•

en:absence of some scapular muscles (less common)

•

en:muscle biopsy shows decreased or absent dysferlin staining

•

en:muscle aches, cramps

•

en:amyotrophy of the upper limbs (in some patients)

•

en:muscle mri shows fatty infiltration

•

en:muscle atrophy, limb-girdle and proximal

•

en:necrotic and regenerating muscle fibers

•

en:triceps aplasia

•

en:relative sparing of the tibialis anterior

•

en:progressive distal and proximal symmetric limb weakness

•

en:muscle weakness and atrophy, distal

•

en:tremor at birth, involving most skeletal muscle groups, especially jaw muscles and lower limb muscles

•

en:fiber-type variability

•

en:cores have abrupt borders within normal regions of the muscle fiber

•

en:cores contain densely packed myofilaments

•

en:contractures of distal lower limbs

•

en:dystrophic changes, mild, seen on muscle biopsy

•

en:proximal weakness of the lower limbs with longer disease duration

•

en:loss of subcutaneous adipose tissue in limbs

•

en:muscle weakness lower limb

•

en:muscle weakness, lower limbs (patient a)

•

en:muscle fiber splitting

•

en:muscle fatigability

•

en:distal leg muscle atrophy

•

en:electromyography shows myotonic discharges

•

en:decreased activity of mitochondrial complex i

•

en:cervical muscle weakness

•

en:atrophy of the muscles in the anterior compartment of the lower leg

•

en:myopathic episodes triggered by exercise, fasting, infection, cold temperatures

•

en:myasthenic syndrome (hcs)

•

en:distal muscle weakness, predominantly affecting the lower limbs

•

en:positive staining for slow myosin heavy chain

•

en:emg in myotonia permanens shows continuous myotonic activity

•

en:subsarcolemmal lipofuscin-positive deposits

•

en:ragged red fibers (in some patients)

•

en:nemaline bodies (rods) on gomori trichrome staining

•

en:emg shows polyphasic continuous motor unit discharges

•

en:emg may show myopathic features

•

en:dystrophic changes occur later

•

en:distal muscle weakness (first affects anterior leg muscles, then posterior leg muscles)

•

en:distal muscle atrophy of the upper limbs (in some patients)

•

en:tubular aggregates seen on biopsy

•

en:subsarcolemmal aggregates of abnormal mitochondria with concentric lamellar membranes

•

en:rhabdomyolysis (in some patients) endocrine : hypogonadotropic hypogonadism (rare)

•

en:primary myopathic changes seen on emg

•

en:degenerative changes with increased connective tissue

•

en:groups of atrophic fibers seen on muscle biopsy (type i fiber predominance)

•

en:interosseus muscles involved

•

en:muscle atrophy restricted to the upper limb

•

en:proximal muscles more often affected

•

en:symmetrical muscle wasting

•

en:muscle biopsy shows small, membrane-bound vacuoles predominantly in type 2 fibers

•

en:muscle weakness, variable

•

en:muscle weakness after cooling or on warming affected muscle

•

en:necrotic muscle fibers

•

en:nonspecific myopathic changes seen on biopsy (in some patients)

•

en:rhabdomyolysis (in some patients)

•

en:tubular aggregates in type 2 skeletal muscle fibers

•

en:decreased thiamine pyrophosphate

•

en:emg shows reduction of voluntary recruitment

•

en:hypotonia, infantile, severe

•

en:knee and hip flexor weakness due to peripheral neuropathy

•

en:mild muscle atrophy in forearm muscles

•

en:muscle weakness (in 90% of patients)

•

en:muscle biopsy shows atrophic fibers

•

en:myopathic changes on pathology

•

en:abnormal irregular myofibrillar network

•

en:decreased hand grip strength

•

en:decreased numbers of postsynaptic nerve terminals at the neuromuscular junction

•

en:mild kinetic abnormalities of the achr (in some patients)

•

en:nemaline bodies (rods) on gomori trichrome staining seen on muscle biopsy

•

en:attacks precipitated by hypokalemia, administration of glucose or insulin, heavy carbohydrate consumption, stress, fatigue, rest after exercise

•

en:decreased glycosylation of alpha-dystroglycan

•

en:fiber-type predominance seen on muscle biopsy (in some patients)

•

•

en:muscle pain (less common)

•

en:lipid droplets seen on muscle biopsy

•

en:subcutaneous fat markedly reduced (in some patients)

•

en:muscle biopsy shows decreased muscle-specific phosphorylase kinase activity

•

en:deposits immunoreactive to beta-amyloid protein

•

en:muscle cramps (also seen in some heterozygotes)

•

en:muscle weakness begins proximally

•

en:myopathy (in some patients)

•

en:panniculitis

•

en:prolonged endplate potentials

•

en:secondary loss of sarcolemmal caveolin-3

•

en:distal muscle atrophy due to neurologic disease

•

en:minimal muscle mass

•

en:muscle biopsy shows neurogenic atrophy affecting both fibers types

•

en:muscle biopsy shows ragged-red fibers with decreased cox activity

•

en:myopathy, mild

•

en:secondarily decreased activities of mitochondrial respiratory enzymes (in some patients)

•

en:deep finger muscle weakness

•

en:cranial muscles spared

•

en:difficulty running

•

en:hang weakness

•

en:muscle biopsy shows myofibrillar disruption

•

en:muscle weakness, proximal, slowly progressive

•

en:plaques immunoreactive for desmin and alpha-beta-crystallin

•

en:tubular aggregates mainly in type 2 fibers and are subsarcolemmal or intermyofibrillar and stain for nadh-tetrazolium reductase

•

en:decreased activity of multiple mitochondrial respiratory complex enzymes

•

en:muscle biopsy shows fibrosis and increased connective tissue

•

en:muscle biopsy is immunopositive for merosin (156225)

•

en:muscle biopsy shows centralized nuclei

•

en:muscle fiber atrophy, profound (rare)

•

en:muscle biopsy shows intranuclear tubulofilamentous inclusions

•

en:muscle biopsy shows nonspecific myopathic changes

•

en:muscle fibers contain internal nuclei

•

en:muscle atrophy, severe

•

en:muscle fiber necrosis

•

en:muscle atrophy (1 patient)

•

en:mitochondrial dna depletion (20 to 35% of normal) seen on skeletal muscle biopsy

•

en:muscle atrophy, proximal, upper and lower limbs

•

en:mri shows fatty replacement

•

en:lack of integrin alpha-7 staining

•

en:mitochondrial paracrystalline inclusion bodies

•

en:lymphedema of lower limbs (in some patients)

•

en:lymphedema, dorsa of feet

•

en:lower limbs more affected than upper limbs

•

en:localized cellulitis

•

•

en:limb lymphedema (in some patients)

•

en:myopathy (rare)

•

en:muscular weakness, limb-girdle (patient a)

•

en:proximal muscle weakness, lower limbs, mild

•

en:nemaline rods (rare)

•

en:quadriceps aplasia

•

en:stiffness (uncommon)

•

en:soft tissue or tendinous calcinosis may occur

•

en:small endplate

•

en:short and thickened z-discs

•

en:shortening of flexor profundus muscle-tendon unit

•

en:scapuloperoneal muscular atrophy due to denervation

•

en:respiratory distress (congenital form)

•

en:repetitive action potentials in response to single nerve stimulation

•

en:reduced lower limb subcutaneous fat

•

en:reduced activity of mitochondrial respiratory chains (1 family)

•

en:proximal muscle weakness and atrophy (may occur later)

•

en:nemaline rod formation

•

en:proximal muscle weakness, mild

•

en:increased endomysial connective tissue around muscle fibers

•

en:proximal and distal muscle atrophy

•

en:prominent muscular appearance

•

en:prominent involvement of the biceps brachii muscles

•

en:prolonged miniature endplate currents

•

en:predominance of oxidative fibers

•

en:poor muscle bulk

•

en:poor head control in infancy

•

en:neurogenic atrophy of muscle fibers seen on biopsy (in some patients)

•

en:neonatal hypertonias

•

en:inguinal hernia

•

en:facial edema

•

en:inability to jump or squat

•

en:attacks of weakness

•

en:decreased muscle bulk

•

en:decreased endplate potential and amplitudes

•

en:decreased cytochrome c oxidase activity

•

en:decreased activity of respiratory complex i+iii

•

en:decreased activity of mitochondrial complexes i and iv

•

en:cytochrome c oxidase-negative fibers

•

en:cellulitis or infection may occur

•

en:calf pseudohypertrophy rare

•

en:calf hypertrophy (in some patients)

•

en:biceps aplasia

•

en:apoptotic nuclei

•

en:decreased numbers of achr seen on muscle biopsy

•

en:ankle clonus

•

en:amyotrophy, neurogenic

•

en:affected muscles show atrophy

•

en:adipose tissue shows many adipocytes with multiple small lipid droplets rather than a normal single lipid droplet

•

en:accelerated decay of the synaptic current

•

en:abnormal sarcoplasmic reticulum elements

•

en:abnormal fat distribution

•

en:abnormal fatigue

•

en:abnormal aggregation of mitochondria

•

en:thigh hypertrophy

•

en:decreased muscle mass, especially distally

•

en:decreased postsynaptic areas of clefts and folds seen on muscle biopsy

•

en:hypotonia (untreated hypothyroidism)

•

en:enlarged nuclei with central pallor

•

en:hypotonia, profound

•

en:hypotonia, mild (1 patient)

•

en:hypertrophy of calves (in 3 of 6 patients)

•

en:head drop due to neck muscle weakness

•

en:fragmented mitochondrial network

•

en:fiber size variation seen on muscle biopsy

•

en:fat pad between achilles tendon and medial malleolus

•

en:fat pads on the hands and feet

•

en:fatty infiltration of affected muscles

•

en:exertional fatigue

•

en:emg shows neurogenic changes consistent with denervation

•

en:decremental response on 3-hz repetitive nerve stimulation

•

en:emg shows myopathic pattern

•

en:emg shows denervation

•

en:emg may showed myotonic discharges

•

en:edema, subcutaneous, generalized

•

en:easy bruisability of lower extremities

•

en:dystrophic changes

•

en:distal muscle weakness occurs later

•

en:distal muscle weakness, mild

•

en:distal muscle weakness

•

en:deposition of complement proteins c5b-9 of the membrane attack complex on muscle fibers

•

en:subsarcolemmal accumulation of mitochondria seen on skeletal muscle biopsy

•

en:decreased activity of cytochrome c oxidase seen on muscle biopsy

•

en:upper limb involvement and distal muscle involvement may occur later in disease course (often by second decade)

•

en:muscle biopsy shows small rounded fibers

•

en:muscle weakness is predominantly of extremities and tongue

•

en:muscle weakness (in some patients)

•

en:muscle weakness, severe

•

en:muscle weakness, proximal limb muscle, mild to moderate

•

en:muscle weakness, congenital

•

en:muscle wasting in lower limbs

•

en:muscle pain after exercise

•

en:muscle fiber splitting (in some patients)

•

en:muscle fatigue

•

en:muscle biopsy shows type 2 fiber atrophy

•

en:muscle biopsy shows pleomorphic hyaline, granular, and amorphous deposits that stain with gomori trichrome

•

en:myofibrillar disorganization

•

en:muscle biopsy shows lipid deposition

•

en:muscle biopsy shows hypoglycosylation of alpha-dystroglycan

•

en:muscle biopsy shows dystrophic features

•

en:muscle atrophy appears later in disease course

•

en:muscle atrophy, upper and lower limbs

•

en:muscle atrophy, progressive

•

en:muscle amyotrophy

•

en:misplaced mitochondria seen on skeletal muscle biopsy

•

en:lymphoscintigraphy shows impaired lymphatic uptake and drainage

•

en:lymphedema of the lower limbs (swelling is confined to below the knees)

•

en:myoclonic spasms

•

en:myopathy, mild to severe

•

en:loss of subcutaneous adipose tissue primarily in gluteal region and lower limbs

•

en:shortened open channel duration

•

en:z-disk streaming

•

en:vacuolar membranes immunostain with sarcolemmal proteins

•

en:wheelchair dependency in 20% of patients by age 40

•

en:walking delay

•

en:underdeveloped muscles (in some patients)

•

en:subsarcolemmal hyaline bodies in 25-30% type i fibers only

•

en:subcutaneous edema

•

en:some patients become wheelchair-dependent

•

en:small, angulated muscle fibers seen on muscle biopsy

•

en:skeletal muscle tissue shows 14 to 45% depletion of mitochondrial dna (mtdna)

•

en:rimmed vacuoles on biopsy

•

en:necrotic and atrophic fibers with centralized nuclei

•

en:respiratory muscles may be involved (more common in juvenile-onset)

•

en:replacement of myofibers with connective tissue

•

en:reduced miniature endplate potential (mepp) amplitude

•

en:proximal muscle weakness, limb-girdle distribution

•

en:progressive proximal muscle involvement

•

en:progressive ectopic ossification (neck, dorsal trunk, proximal limbs, sternocleidomastoid, masseters)

•

en:preservation of visceral, neck, and axillary fat pads

•

en:potassium sensitivity has been reported

•

en:paucity or absence of lymph nodes in the axillae and above the inguinal ligaments seen on scintilymphangiography

•

en:partial lipodystrophy (abnormal distribution of adipose tissue)

•

en:low maximum workload on exercise testing

•

en:muscular dystrophy (in 1 of 3 patients)

•

en:loss of ambulation between third and sixth decade

•

en:biopsy shows myopathy without vacuoles

•

en:decreased or absent ankle reflexes

•

en:decreased muscle mass (in some patients)

•

en:decreased collagen vi

•

en:decreased amplitude of miniature endplate potentials (mepp)

•

en:decreased activity of mitochondrial complex iii

•

en:decreased activity of mitochondrial complexes i and iv seen on skeletal muscle biopsy

•

en:decreased activity of cytochrome c oxidase (in most cases)

•

en:congenital myopathy (in one patient)

•

en:chronic weakness

•

en:calcific tendinopathy, early-onset (in some patients)

•

en:benign soft tissue developmental anomalies

•

en:defects in mitochondria respiratory activities, mainly complexes i, ii, and iv

•

en:atrophy of type 1 and type 2 fibers

•

en:atrophy of shins

•

en:atrophic fibers seen on biopsy

•

en:arm/shoulder muscle hypoplasia

•

en:absence of myotonia in infancy (congenital form)

•

en:abnormal fat accumulation below the triceps (in some patients)

•

en:abnormalities in myofibril organization

•

en:lipohypoplasia, regional

•

en:z-line streaming see on electron microscopy

•

en:z-disk degeneration

•

en:defective mitochondrial oxidative phosphorylation of multiple enzymes

•

en:decreased activities of mitochondrial-encoded respiratory chain complexes

•

en:difficulty in toe walking

•

en:generalized hypotonia due to defect at the neuromuscular junction

•

en:lipoatrophy, generalized

•

en:limb muscular atrophy

•

en:increased muscle tone at birth

•

en:increased muscle tone, neonatal (in severely affected patients)

•

en:increased central nucleation

•

en:imaging shows progressive fatty infiltration of muscle

•

en:hypotonia (families a and b)

•

en:hypertrophy of the extensor digitorum brevis muscles

•

en:hypertonia late

•

en:gluteus maximus and thigh adductors most affected

•

en:generalized muscular appearance from birth

•

en:glycogen accumulation seen on biopsy

•

en:frequent falls

•

en:difficulty walking, running, climbing stairs

•

en:fibrillations in affected muscles

•

en:emg shows neurogenic changes

•

en:easily fatigued (finding)

•

en:duchenne muscular dystrophy (dmd, 310200) in 'complex' form

•

en:distal muscle atrophy (1 patient)

•

en:fibrous dysplasia (rare)

•

en:distal limb muscle weakness due to peripheral neuropathy (lower limbs are more affected than upper limbs)

•

en:disruption of sarcomeres with disorganization of the z band

•

en:muscle biopsy shows myodegenerative changes with beta-amyloid and phosphorylated tau deposits

•

en:muscle biopsy shows fiber type disproportion

•

en:muscle biopsy shows increased variation in fiber size

•

en:muscle biopsy shows mitochondrial paracrystalline inclusions

•

en:muscle hyperirritability

•

en:muscle biopsy shows nemaline rods

•

en:muscle coenzyme q deficiency

•

en:muscle strength and bulk is preserved

•

en:mitochondria dna deletion

•

en:muscle mitochondria normal by histochemical analysis

•

en:muscle biopsy may show inflammatory changes

•

en:involves upper and lower proximal muscles

•

en:mitochondrial complex i deficiency

•

en:mitochondrial complex iii deficiency, isolated, seen on muscle biopsy

•

en:mildly reduced respiratory enzyme activities except for complex ii

•

en:merosin-positive biopsy

•

en:lymphedema, of upper and/or lower extremity (rare)

•

en:loss of gluteal adipose tissue

•

•

en:lipid storage, mainly in type i fibers

•

en:increased opening duration of acetylcholine receptor (achr)-induced ion channels

•

en:muscle weakness (cvs+)

•

en:increased variation in fiber size seen on muscle biopsy

•

en:muscle weakness, distal, particularly affecting the hands

•

en:some abnormal aggregation of mitochondria

•

en:muscular appearance

•

en:proximal limb muscle weakness (occurs later)

•

en:increased internal nuclei

•

en:thenar amyotrophy (rare)

•

en:superior rectus atrophy

•

en:smooth muscle may also become involved

•

en:small, firm, rubbery, flesh-colored nodules most commonly found on the head, neck, and trunk

•

en:skeletal muscle biopsy shows impaired respiratory oxidation

•

en:shortening of various muscle-tendon groups in feet

•

en:scattered necrotic fibers

•

en:reduced muscle tone but normal power

•

en:rectus medial atrophy

•

en:rare necrotic fibers

•

en:progressive interictal weakness is common

•

en:myofibrillar disintegration

•

en:painful swelling in aponeuroses

•

en:no facial muscle involvement

•

en:normal or decreased facial and neck adipose tissue

•

en:nonspecific muscle fiber atrophy

•

en:non-pitting edema

•

en:neurogenic abnormalities seen on emg

•

en:neck muscle hypoplasia

•

en:neck and proximal limb muscle myopathy

•

en:myotonia (delayed muscle relaxation after contraction)

•

en:myositis (in some patients)

•

•

en:increased mitochondria with rare paracrystalline inclusions

•

en:abnormal iron deposition in mitochondria

•

en:increased centralized nuclei

•

en:bulbar weakness

•

en:decreased glycosylation of alpha-dystroglycan seen on muscle biopsy

•

en:decreased coenzyme q10

•

en:decreased activity of cytochrome c oxidase in most cases seen on muscle biopsy

•

en:decreased achr at the endplate

•

en:decreased ability to run

•

en:contractures of upper limbs (in some patients)

•

en:congenital fiber type disproportion

•

en:cellulitis due to immunodeficiency

•

en:calf muscle hypertrophy

•

en:calf hypertrophy (reported in 1 family)

•

en:buffalo hump

•

en:decreased mtdna

•

en:biopsy shows defects in pyruvate oxidation

•

en:bilateral facial weakness (congenital form)

•

en:ascites (in some patients)

•

en:areflexia of lower limbs

•

en:amyotrophy affects c5 to t1 myotomes

•

en:absence of subcutaneous fat over entire body except buttocks, hips, and thighs

•

en:abnormal z bands

•

en:abnormal muscle fibers with amorphous, granular, or hyaline deposits

•

en:abnormal fiber size variation

•

en:abnormally long mitochondria seen on muscle biopsy

•

en:upper limb muscle weakness may be more severe than lower limb weakness

•

en:decreased mitochondrial respiratory activities (in some patients)

•

en:decreased muscle mitochondrial aconitase

•

en:increased adipose fibrosis

•

•

en:impaired mitochondrial respiration

•

en:immunoreactivity for z-disk proteins

•

en:hypotonia from birth to age 12

•

en:generalized limb muscle atrophy

•

en:filamentous inclusions in muscle fibers

•

en:exercise intolerance (less common)

•

en:excessive neutral fat and free fatty acids in type-i fibers

•

en:edema of hands and feet (in some patients)

•

en:edema is present at birth and then slowly decreases

•

en:edema (hands and feet)

•

en:dystrophic changes may be present

•

en:distal muscle weakness due to neuropathy

•

en:decreased numbers of type 2b fibers

•

en:distal muscle wasting, mild

•

en:distal muscle atrophy due to peripheral neuropathy, lower limbs more affected than upper limbs

•

en:distal amyotrophy (hands and feet)

•

en:disarray of mitochondrial cristae seen on muscle biopsy

•

en:difficulty rising from chair

•

en:deltoid muscle hypoplasia

•

en:delayed motor development (cvs+)

•

en:degrading mitochondria

•

en:deficiency of mitochondrial respiratory enzymes seen on muscle biopsy

•

en:defective glycosylation of alpha-dystroglycan seen on biopsy

•

en:decreased postsynaptic length

•

en:trunk muscle atrophy

•

en:mild decrease in mitochondrial respiratory chain activity

•

en:vacuole membranes show atpase reactivity consistent with origin from the sarcoplasmic reticulum

•

en:muscle hypertrophy may occur

•

en:nemaline rods may be observed

•

en:nemaline bodies are rarely intranuclear

•

•

en:nearly complete absence of metabolically active adipose tissue (subcutaneous, intraabdominal, intrathoracic)

•

en:myopathic changes seen on emg

•

en:muscle weakness (affecting lower proximal extremities, abdominal wall, and iliopsoas muscle)

•

en:muscle weakness, predominantly proximal

•

en:muscle weakness, mainly proximal

•

en:muscle weakness, limb-girdle, mild

•

en:muscle hypotonia

•

en:muscle biopsy shows type 1 fiber predominance

•

en:neuropathic process seen on muscle biopsy

•

en:muscle biopsy shows sarcoplasmic pas-positive vacuoles

•

en:muscle biopsy shows neurogenic atrophy (1 patient)

•

en:muscle atrophy, proximal and distal (predominant lower limb involvement)

•

en:muscles become hard and tender during exercise

•

en:multiple mitochondrial respiratory enzymes deficiencies seen on biopsy

•

en:mri shows fatty infiltration of affected muscles

•

•

en:minicores extend full fiber diameter

•

en:lower limb muscle hypotrophy

•

en:loss of facial adipose tissue

•

en:limb hypertonia

•

en:neurogenic changes later in disease seen on emg

•

en:normal alpha-glucosidase or acid maltase activity (gaa, 606800)

•

en:lafora bodies (accumulation of polyglucosan) seen on skeletal muscle biopsy

•

en:small and incompletely fused muscle fibers seen on biopsy

•

en:walking may be limited

•

en:z-disks with abnormal homogeneous material

•

en:weakness worsened by activity

•

en:virtually no active movement at birth (wws)

•

en:type ii fiber atrophy seen on muscle biopsy

•

en:type 2 fiber hypertrophy

•

en:thin filament shortening and disorganization (in some patients)

•

en:symmetrical, proximal limb muscle atrophy (pelvic, scapular, trunk muscles)

•

en:subsarcolemmal accumulation of normal mitochondria (in some patients)

•

en:subcutaneous lipomatous tissue

•

en:spheroid bodies are composed of fine filamentous (myofibrillar) material

•

en:skeletal muscle shows decreased sarcoglycan proteins

•

en:normal neonatal period may occur before weakness is apparent

•

en:signs of denervation seen on biopsy

•

en:severely decreased or absent lamp2 protein

•

en:secondarily decreased activities of mitochondrial respiratory enzymes (1 patient)

•

en:scapuloperoneal amyotrophy

•

en:rhabdomyolysis may occur

•

en:recovery between attacks

•

en:prominent involvement of the quadriceps femoris muscles

•

en:preserved junctional folds

•

en:percussion myotonias

•

en:percussion-induced muscle mounding (muscle rippling)

•

en:pelvic girdle muscle atrophy

•

en:limb-girdle muscular dystrophy

•

en:secondary loss of merosin and desmin

•

en:isolated mitochondrial complex iv deficiency seen on biopsy

•

en:accumulation of intrasarcoplasmic granulofilamentous aggregates that are immunoreactive to desmin and alpha-beta-crystallin

•

en:cores or minicores

•

en:complex v deficiency

•

en:cap structures, when present, contain disorganized myofibrils and thickened z bands

•

en:calf hypertrophy (early in the disease)

•

en:bilateral foot drop

•

en:a subset of patients develop bilateral weakness

•

en:attacks precipitated by potassium

•

en:areflexia due to muscle weakness

•

en:angulated atrophic fibers

•

en:acquire ability to walk and jump in childhood, but motor regression occurs later

•

en:accumulated lipid droplets seen on muscle biopsy

•

en:decreased activity of respiratory complex ii+iii

•

en:absence of spontaneous activity at birth (severe form)

•

en:absence of merosin in muscle

•

en:abnormal variation in fiber type seen on muscle biopsy

•

en:abnormal mitochondria in skeletal muscle biopsy

•

en:abnormal mitochondrial morphology

•

en:abnormal jitter seen on emg

•

en:abnormal aggregates of desmin and filamin c

•

en:weak extraocular muscles

•

en:weakness of the muscles in the anterior compartment of the lower leg (particularly the tibialis anterior muscle)

•

en:wasting of calf muscles (rare)

•

en:increased variability in muscle fiber diameter

•

en:cox-negative fibers

•

en:absence of caveolin-3 staining

•

en:decreased caveolin-3 expression seen on muscle biopsy

•

en:familial generalized lipodystrophy

•

en:increased mitochondria with abnormal cristae

•

en:decreased immunostaining for succinate dehydrogenase (mitochondrial complex ii)

•

en:increased endomysial fibrosis

•

en:inability to run

•

en:hypotonia, severe (patient b)

•

en:hyporeflexia or areflexia

•

en:group fiber atrophy (in some patients)

•

en:grip strength decreased

•

en:generalized muscle weakness

•

en:fiber type grouping

•

en:fasciculations (less common)

•

en:hemihypertrophy of right arm and leg (rare)

•

en:exercise capacity decreased

•

en:difficulty walking up stairs

•

en:exercise-induced myalgia

•

en:decreased mitochondrial complex v activity

•

en:decremental response to repetitive nerve stimulation

•

en:deep rerouting of lymph in lower limbs seen on lymphoscintigraphy

•

en:distal limb muscle weakness and atrophy

•

en:distal lower limb muscle weakness due to peripheral neuropathy

•

en:distal muscle weakness and atrophy, upper and lower limbs

•

en:emg shows chronic denervation

•

en:emg shows fasciculations

•

en:decreased muscle succinate dehydrogenase

•

en:muscle biopsy shows subsarcolemmal nemaline bodies (rods) on gomori trichrome staining

•

en:muscle biopsy shows degeneration of muscle fibers, variation in fiber size, fiber splitting, rimmed vacuoles, and central myonuclei

•

en:muscle hypertrophy of the lower extremities

•

en:muscle biopsy shows small fibers with central nuclei and accumulation of mitochondria in the central part of the fibers

•

en:muscle weakness, limb-girdle (lower and upper limbs may be affected)

•

en:muscle biopsy shows neurogenic atrophy

•

en:muscle biopsy shows groups of small angulated fibers consistent with denervation

•

en:increased number of endplate regions distributed over increased span of muscle fiber

•

en:mild weakness of the small hand muscles

•

en:macroglossia

•

en:loss of subcutaneous adipose tissue from gluteal region

•

en:intermyofibrillar and subsarcolemmal accumulation of electron-dense material (in some patients)

•

en:increased muscle tone (early in life)

•

en:hypotonia (2 patients)

•

en:muscle weakness, proximal greater than distal

•

en:hypotonia, severe, persistent

•

en:hyporeflexia

•

en:muscle weakness, proximal, distal, and axial, severe

•

en:replacement of affected muscle tissue with fatty tissue

•

en:muscle weakness and atrophy

•

en:relatively preserved limb strength

•

en:subsarcolemmal accumulations of abnormally shaped mitochondria (on electron microscopy)

•

en:hyaline inclusion

•

en:sparing of the anterior tibial compartment

•

en:sparing of anterior tibialis muscle

•

en:slow motor responses to sudden events (i.e., falling)

•

en:shoulder weakness and atrophy

•

en:sarcoplasmic or subsarcolemmal vacuoles in muscle fibers seen on muscle biopsy

•

en:proximal muscle weakness (120270.0002)

•

en:muscle weakness of limb

•

en:proliferation of fatty tissue in muscle (in some patients)

•

en:poor musculature

•

en:pain or cramping during sustained manual activity

•

en:neuropathic or myopathic changes seen on emg

•

en:myalgia, episodic

•

en:muscular fasciculation

•

en:muscle weakness trunk

•

en:hypertonicity (uncommon)

•

en:decreased mitochondria

•

en:glycogenosis of skeletal muscle, mild (in some patients)

•

en:chronic neurogenic changes seen on emg

•

en:decreased or patchy amounts of alpha-dystrobrevin and beta-2-syntrophin at the sarcolemma

•

en:decreased muscle mass (predominantly in lower extremities)

•

en:decreased mitochondrial respiratory chain enzyme activity (patient b)

•

en:decreased mitochondrial complex iv activity (in some patients)

•

en:decreased immunostaining for alpha-sarcoglycan

•

en:cytochemical and em muscle studies show large, bizarre mitochondria in striated muscle

•

en:cox-depleted fibers

•

en:attacks precipitated by rest after exercise

•

en:degenerative features seen on muscle biopsy

•

en:attacks last 4 to 24 hours

•

en:atrophy of the thenar and hypothenar muscles

•

en:atrophy of ankle and toe extensor (dorsiflexor) muscles

•

en:atrophic skeletal muscle fibers on myosin staining

•

en:acute rhabdomyolysis

•

en:abnormal mitochondrial proliferation

•

en:usually a unilateral disorder

•

en:degeneration of junctional folds

•

en:denervation of skeletal muscles

•

en:generalized muscle weakness, particularly affecting the limbs

•

en:emg may show neurogenic changes

•

en:generalized hypotonia

•

en:fiber type variation

•

en:facial muscle atrophy of involved side

•

en:exercise intolerance (also seen in some heterozygotes)

•

en:exercise-induced weakness

•

en:exercise-induced muscle cramps

•

en:episodic, nonpruritic, nonurticarial, nonpitting edema

•

en:electron microscopy shows subsarcolemmal accumulations of abnormally shaped mitochondria

•

en:difficulty walking and climbing stairs

•

en:electron microscopy shows abnormal mitochondria with disorganized and vacuolated cristae

•

en:edema reoccurs with infections

•

en:dystrophic skeletal muscle seen on biopsy

•

en:dystrophic changes seen on skeletal muscle biopsy

•

en:distal muscle atrophy (lower limbs more affected than upper limbs)

•

en:distal limb muscle weakness occurs later

•

en:disruption of the m-line

•

en:transient muscle weakness occur in 75% of patients, particularly in the arms and hands

•

en:decreased glutamate oxidation (about 63% of normal)

•

en:variable decreases in mitochondrial respiratory complex enzyme activities

•

en:muscle fiber immaturity

•

en:neurogenic atrophy

•

en:myotonic discharges

•

en:myopathy in approximately 45% of patients

•

en:myopathic features seen on biopsy

•

en:muscle weakness may affect upper limbs

•

en:muscle weakness and atrophy, proximal

•

en:muscle rigidity

•

en:muscle biopsy shows ragged red fibers

•

en:peroneal muscle atrophy

•

en:muscle biopsy shows necrotic and atrophic fibers with centralized nuclei

•

en:muscle biopsy shows inflammation with t cells

•

en:muscle biopsy shows atrophy

•

en:muscle biopsy may show deficiency of multiple mitochondrial respiratory complexes

•

en:multi-core congenital myopathy

•

en:mri of the calves shows fatty atrophy with preservation of the medial gastrocnemius in the posteromedial compartment

•

en:mitochondrial proliferation

•

en:paradoxical myotonia (myotonia increases with exercise)

•

en:pharyngeal muscle weakness

•

en:mild muscle weakness

•

en:type 1 fibers are at least 12% smaller than type 2 fibers

•

•

en:waddling gait

•

en:vacuoles predominantly in type 2 fibers seen on muscle biopsy

•

en:vacuoles are autophagocytic

•

en:vacuolar degeneration

•

en:type 2 muscle fiber atrophy

•

en:type 1 fiber predominance

•

en:superficial rerouting of lymph through the skin

•

en:proximal muscle atrophy (in some patients)

•

en:small type ii fibers

•

•

en:reduced muscle mass

•

en:pyruvate oxidation defect

•

en:proximal weakness

•

en:proximal myopathy

•

en:proximal muscle weakness more severe than distal muscle weakness

•

en:proximal muscle weakness

•

en:mitochondrial dna depletion, severe

•

en:pectoralis major hypoplasia

•

en:mild atrophy of the proximal lower limbs

•

en:calf and thigh cramping muscle pains

•

en:distal muscle atrophy due to peripheral neuropathy of upper and lower limbs

•

en:distal muscle atrophy due to peripheral neuropathy

•

en:distal muscle atrophy, affecting the lower limbs

•

en:distal lower limb amyotrophy

•

en:distal limb muscular atrophy due to peripheral neuropathy

•

en:disruption of the sarcolemmal membrane seen on muscle biopsy

•

en:chronic denervation seen on emg

•

en:biopsy of adipose tissue shows reduced adipocyte size

•

en:distal muscle weakness, lower limbs more severely affected than upper limbs

•

en:axial muscle weakness

•

en:axial hypotonia (in some patients)

•

en:atrophic muscle fiber on biopsy

•

en:anterior tibial muscles first involved

•

en:lack of facial subcutaneous fat

•

en:amyotrophy (1 patient)

•

en:adhalin deficiency seen on muscle biopsy

•

en:distal muscle weakness, affecting the lower limbs

•

en:difficulty walking

•

en:disuse atrophy

•

en:fatty infiltration

•

en:increased perisarcolemmal calcium deposition

•

en:increased internal nuclei (in some patients)

•

en:increased connective tissue and fat in muscles

•

en:inclusions are dnajb6-immunoreactive

•

en:hypotonia at birth

•

en:hypoplasia of the hand muscles (29%)

•

en:hypoglycosylation of alpha-dystroglycan

•

en:floppy infant syndrome

•

en:gastrocnemius and soleus muscles most affected

•

en:facial muscle weakness and atrophy, progressive

•

en:enlarged terminal cisternae of the sarcoplasmic reticulum

•

en:emg shows myopathy

•

en:electron microscopy shows dense material emanating from the z-disk

•

en:edema of lower extremity

•

en:edematous hands and feet (1 patient)

•

en:easy fatigability

•

en:pena-shokeir syndrome type i

•

en:phagocytic vacuoles with degraded membranous material

•

en:myofibril destruction (in some patients)

•

en:pectoralis muscles may be less involved, leading to inward shrugging posture

•

en:normal phosphorylase kinase activity in muscle

•

en:neonatal hypotonia muscle biopsy shows pas-positive vacuoles

•

en:necrotic fibers

•

en:myotonia is present in majority of cases

•

en:myotonia improves with continued activity ('warm-up phenomenon')

•

en:muscle biopsy shows necrotic and regenerating fibers

•

en:muscular stiffness

•

en:muscle shows lipid accumulation

•

en:muscle pain and cramping on exertion

•

en:muscle fibers appear as fetal myotubules

•

en:muscle cramps, painful, recurrent

•

en:muscle biopsy shows abnormal mitochondria

•

en:muscle biopsy shows glycogen storage

•

en:muscle biopsy shows decreased activity of cytochrome c oxidase

•

en:preserved junctional structure seen on muscle biopsy

•

en:premature exertional muscle weakness

•

en:attacks may present during or after sleep

•

en:prominent veins, lower limbs

•

en:skeletal muscle tissue shows depletion of mitochondrial dna (mtdna)

•

en:muscle atrophy, primarily in the legs

•

en:chronic fatigable muscles

•

en:broad-based gait

•

en:attacks relieved by potassium administration

•

en:absence of pectoralis minor muscle

•

en:variation in fibrodiameter seen on muscle biopsy

•

en:type 1 fiber predominance seen on muscle biopsy

•

en:structurally abnormal mitochondria

•

en:skeletal muscle biopsy shows reducing bodies

•

en:proximal muscle weakness (in some patients)

•

en:skeletal muscle biopsy shows enlarged mitochondria with abnormal cristae decreased mitochondrial complex i activity

•

en:shoulder muscle weakness (in some patients)

•

en:severe muscular hypotonia

•

en:rounded, atrophic fibers (family a)

•

en:rhabdomyolysis

•

en:relative sparing of the rectus femoris

•

en:reduced muscle bulk

•

en:quadriceps atrophy (later onset)

•

en:muscle atrophy in the limbs

•

•

en:muscle, weakness, distal, hands and fingers (in some patients)

•

en:calf atrophy (later onset)

•

en:decremental muscle response to repetitive nerve stimulation

•

en:decreased muscle density on imaging

•

en:cores with lack of oxidative activity and mitochondrial depletion may also be found and extend along length of fiber

•

en:cores extend along length of muscle fiber

•

en:congophilic eosinophilic inclusions

•

en:chronic denervation seen on skeletal muscle biopsy

•

en:chronic denervation/reinnervation seen on emg

•

en:centralized nuclei, rare

•

en:biopsy shows myopathic and dystrophic changes

•

en:disruption plasma membrane (in some patients)

•

en:axial muscle hyperextension, episodic

•

en:atrophy of neck muscles may occur later

•

en:atrophy, neurogenic muscular

•

en:acquired partial lipodystrophy

•

en:absence of necrosis

•

en:absence of collagen vi immunostaining

•

en:abnormal subcutaneous fat tissue distribution

•

en:cytoplasmic inclusion bodies (finding)

•

en:disorganization of the neuromuscular junction

•

en:distal limb muscle atrophy due to peripheral neuropathy (lower limbs are more affected than upper limbs)

•

en:multiple mitochondrial dna deletions

•

en:hypertonia in infancy

•

en:mitochondrial dna deletion (1 patient)

•

en:minicores or core-like regions may be present

•

en:lymphedema (primarily in lower limbs, but also arms in some patients)

•

en:low-amplitude compound muscle action potential (cmap)

•

en:loss of antigravity strength

•

en:increased echo intensity in affected muscles

•

en:hypotonia, generalized, severe

•

en:hypoplasia of muscle

•

en:generalized neonatal hypotonia

•

en:distal limb muscle weakness (less common)

•

en:gait unsteady

•

en:frontalis muscle weakness

•

en:fibromyalgia

•

en:fibrillation

•

en:fiber size variation (in some patients)

•

en:fatty deposition

•

en:facial paresis

•

en:emg shows fibrillations

•

en:distal muscle weakness of the upper limbs (in some patients)

•

en:congophilic inclusions

•

en:transient eosinophilic myositis (seen on muscle biopsy) in the first decade

•

en:decreased ant1 protein (103220) in muscle tissue

•

en:myopathic findings on biopsy have been occasionally reported

•

en:postexercise cmap amplitude facilitation

•

en:pelvic girdle weakness

•

en:onset of lymphedema around puberty

•

en:normal or increased truncal adipose tissue

•

en:noninflammatory myopathy with rimmed vacuoles and atrophic fibers seen on muscle biopsy

•

en:neurogenic changes seen on emg and biopsy

•

en:necrotic changes (finding)

•

en:myopathic pattern seen on emg

•

en:myogenic profile on electromyography

•

en:prolonged achr channel opening episodes

•

•

en:muscular hypotonia of the trunk

•

en:muscle weakness, proximal, lower limbs (upper limbs may become affected later)

•

en:muscle weakness, primarily proximal

•

en:muscle weakness, mild, proximal and distal

•

en:muscle weakness, distal and proximal, lower limbs (1 family)

•

en:muscle pain (in some patients)

•

en:muscle hematoma

•

en:progression to proximal muscle weakness

•

en:proximal muscle weakness, lower limbs, slowly progressive (1 of 3 patients)

•

en:muscle biopsy shows mitochondrial aggregates

•

•

en:decreased exercise tolerance

•

en:wasting, especially temporal, neck, and facial muscles

•

en:variable deficiencies of mitochondrial respiratory chain complexes i, iii, and iv

•

en:variability in fiber size

•

en:type 1 fiber atrophy

•

en:truncal hypotonia (family a)

•

•

en:swelling of the affected areas

•

en:sparing of small hand and finger muscles

•

en:proximal muscle weakness (occasional)

•

en:slowly progressive limb-girdle myopathy

•

en:shoulder girdle weakness

•

en:secondary decrease of calpain-3 (capn3, 114240) protein expression in muscle

•

en:scapular muscle atrophy

•

en:sarcoplasmic inclusions

•

en:redundancy of basal lamina with accumulated debris

•

en:red-ragged fibers (2p21del)

•

en:quadriceps muscle spared

•

en:muscle fibers are immunoreactive for desmin and vimentin

•

en:proximal muscle weakness (85% of patients)

•

en:muscle biopsy shows glycogen accumulation in myofibrils and lysosomes

•

en:edema, generalized

•

en:focal degeneration of junctional folds ('honeycombed' appearance) see on muscle biopsy

•

en:flaccid neck

•

en:finger and wrist extensor weakness

•

en:fiber size variation seen on biopsy (in some patients)

•

en:extensor finger muscle weakness

•

en:enteroviral dermatomyositis syndrome

•

en:endplate abnormalities

•

en:edema at birth

•

en:distal muscle weakness due to peripheral neuropathy

•

en:generalized muscle hypertrophy

•

en:distal limb muscle weakness, lower more than upper

•

en:distal limb muscle atrophy due to peripheral neuropathy

•

en:denuded postsynaptic regions

•

en:delayed ambulation

•

en:degenerate mitochondrial on em

•

en:decremental response of compound muscle action potential on repetitive nerve stimulation

•

en:muscle biopsy shows disruption of the sarcolemmal membrane

•

en:decreased postsynaptic achr

•

en:foot extensor muscle weakness (later onset)

•

en:edema of dorsum of hands and feet

•

en:generalized muscle weakness, proximal and distal

•

•

en:muscle biopsy shows cytochrome c oxidase-negative fibers

•

en:mtdna deletions seen on muscle biopsy

•

en:global muscle weakness

•

en:mitochondrial swelling

•

en:mild weakness

•

en:mildly decreased cytochrome c oxidase activity

•

en:marked muscular hypertrophy

•

en:limb weakness and atrophy

•

en:limb muscle weakness, proximal, upper and lower

•

en:lipoatrophy of trunk

•

en:internal nuclei (in some patients)

•

en:increased fat and fibrous tissue

•

•

en:hypotonia, axial, severe

•

en:inclusion body myopathy

•

en:hip flexor weakness

•

en:increased lipid

•

en:infantile axial hypotonia

•

en:interfibrillar and subsarcolemmal vacuoles

•

en:loss of sarcomeric striations

•

en:increased glycogen

•

en:increased fibrosis

•

en:increased numbers of type 1 fibers

•

en:intermyofibrillar and subsarcolemmal granulofilamentous protein aggregates

•

en:large lipid droplets

•

en:lipid droplet accumulation

•

en:increased fatty and connective tissue in skeletal muscle

•

en:loose connective tissue

•

en:loss of ambulation

•

en:loss of independent ambulation around age 12 years

•

en:muscle biopsy shows loss of myofibrillar organization

•

en:mildly increased mtdna

•

en:minimal subcutaneous fat

•

en:mitochondrial complex iii deficiency (disorder)

•

en:mitochondrial dna depletion (in some)

•

en:multiple mitochondrial dna (mtdna) deletions seen on muscle biopsy

•

•

en:muscle biopsy in acute stage shows increased numbers of abnormal mitochondria

•

en:muscle biopsy shows abnormal fiber size and variation

•

en:muscle biopsy shows variation in fiber size

•

en:hypotonia (patients a and c)

•

en:muscle pain and cramps following exercise

•

en:increased centralized internal nuclei

•

en:decreased shank muscle mass

•

en:hypoplasia of latissimus dorsi muscle

•

en:distal muscle weakness and atrophy of upper and lower limbs due to peripheral neuropathy

•

en:muscle wasting, progressive

•

en:decreased cytochrome c oxidase (cox) activity and protein

•

en:decreased glycosylation of alpha-dystroglycan (dag1, 128239)

•

en:decreased muscle action potential after warming affected muscle

•

en:decremental compound muscle action potential on repetitive stimulation

•

en:degenerating junctional folds

•

en:disorganized myofilaments seen on muscle biopsy

•

en:distal lower limb muscle weakness

•

en:distal muscle atrophy, predominantly lower limbs

•

en:distal muscle weakness, predominantly lower limbs

•

en:electromyographic decrements in some muscles

•

en:hypoplasia of cervical paravertebral muscles

•

en:episodic weakness may or may not occur independent of myotonia

•

en:evidence of reinnervation seen on emg (1 family)

•

en:fatty infiltration seen on muscle biopsy

•

en:fat droplets in sarcoplasm and mitochondria seen on skeletal muscle biopsy

•

en:fat pad anterior to malleolus

•

en:fiber-type grouping pattern

•

en:fiber size variation

•

•

en:gait, drop foot

•

en:hip girdle muscle weakness (usually presenting symptom)

•

en:muscle stiffness or aching

•

en:muscle atrophy, lower limbs more affected than upper limbs

•

en:muscle weakness, episodic

•

•

en:tenderness of lower extremities

•

en:thenar eminence hypoplasia

•

en:umbilical cord bleeding

•

en:upper limb involvement may occur later

•

en:vacuoles containing neutral lipids seen on muscle biopsy

•

en:variably decreased alpha-dystroglycan expression (dag, 128239)

•

en:weakness of anterior compartment tibial muscles

•

en:weakness of the anterior tibial muscle and toe extensors

•

en:wide variation in fiber size

•

en:fasciculation

•

•

en:shoulder weakness

•

en:muscle twitch

•

•

atrophie musculaire neurogène

•

hernie ombilicale

•

hernies ombilicales

•

en:Umbilical hernia

•

en:general paralysis

•

hypotonie musculaire

•

incapable de marcher

•

en:supraclavicular fat pads

•

en:sparing of the brachioradialis muscle (gives appearance of 'oblique amyotrophy')

•

en:shortening of various muscle-tendon groups in legs

•

en:muscle weakness, proximal and distal (predominant lower limb involvement)

•

en:no dystrophic changes

•

en:muscle weakness, symmetric, proximal, lower limbs

•

en:muscle weakness following prolonged exercise

•

en:muscle weakness in forearm muscles

•

en:muscle weakness of proximal and distal upper and lower limbs

•

en:myopathic changes early in disease seen on emg

•

en:myopathic changes seen on emg of affected muscle

•

en:myotonia, potassium-sensitive (may be responsive to acetazolamide)

•

en:nonspecific myopathic changes

•

en:nonspecific myopathy

•

en:normal mitochondrial morphology (1 patient)

•

en:painful swelling in fasciae

•

en:sarcomere disappearance seen on muscle biopsy

•

en:poor development of the postsynaptic membrane

•

en:poor muscle build

•

en:poor muscle mass

•

en:proximal lower limb muscle weakness, later (in some patients)

•

en:proximal muscle weakness, mild, of shoulder and hip girdle muscles (in some patients)

•

en:proximal muscle weakness, upper and lower limbs, due to peripheral neuropathy, later in disease course

•

en:proximal muscle weakness in lower limbs

•

en:relative muscle weakness, especially in pelvic girdle

•

en:repetitive response to single nerve stimulus

•

en:rigidity (uncommon)

•

en:decreased coenzyme q10 content

◀

en:distal muscle

•

• Mathieu Lafourcade • LIRMM (données libres en Creative Commons - C0 domaine public) •

• This page link : https://www.jeuxdemots.org/diko.php?gotermid=7119574 • caches: c1=8 c2=1004 c3=1

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