1. [noun] An unpleasant state of mental uneasiness, nervousness, apprehension and obsession or concern about some uncertain event.
2. [noun] An uneasy or distressing desire (for something).
3. [noun] (pathology) A state of restlessness and agitation, often accompanied by a distressing sense of oppression or tightness in the stomach.
4. [noun] (psychiatry) a relatively permanent state of worry and nervousness occurring in a variety of mental disorders, usually accompanied by compulsive behavior or attacks of panic.
5. [noun] A vague unpleasant emotion that is experienced in anticipation of some (usually ill-defined) misfortune.