1. [proper noun] (geography) The region between the Mediterranean Sea and the Jordan River.
2. [proper noun] The West Bank and Gaza Strip, taken collectively, especially if considered to be (the site of) the State of Palestine.
3. [proper noun] (historical) Any of four Ancient Roman and Byzantine provinces in the eastern Mediterranean: Syria Palaestina, Palaestina Prima, Palaestina Secunda and Palaestina Salutaris.
4. [proper noun] (historical) (technical) A British colonial entity administering approximately the lands of modern State of Israel plus the West Bank and Gaza Strip; the lands administered by this entity.
5. [proper noun] (historical) (technical) (rare) The British League of Nations Mandate for Palestine, of which this region was a part (the remainder being Transjordan, which covered approximately the lands of the modern Kingdom (originally Emirate) of Jordan).